Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Injection-site pain
(2006): Moyes V+, Diabet Med 23(2), 204
Injection-site pruritus
(1988): Plantin P+, Ann Dermatol Venereol (French) 115, 813
Injection-site reactions (sic)
(2003): HOE 901/2004, Diabet Med 20(7), 545 (1 case)
Lipoatrophy (1–10%)
(2006): Beltrand J+, Horm Res 65(5), 253
(2003): Ampudia-Blasco FJ+, Diabetes Care 26(3), 953
(2003): Chowdhury TA+, BMJ 327(7411), 383
(2003): Felner EI, JPediatr142(4), 448
(1998): Murao S+, Intern Med 37, 1031
(1996): Logwin S+, Diabetes Care 19, 255
(1993): Chantelau E+, Exp Clin Endocrinol 101, 194
(1992): Igea JM+, Allergol Immunopathol Madr (Spanish) 20, 173
(1989): Gyimesi A+, Orv Hetil (Hungarian) 130, 2751
(1989): Zinman B, NEnglJMed321, 363
(1988): McNally PG+, Postgrad Med J 64, 850
(1988): Perrot H, Ann Dermatol Venereol (French) 115, 523
(1983): Blickle JF+, Presse Med (French) 12, 2534
(1982): Levandoski LA+, Diabetes Care 5, 6
(1981): Jones GR+, BMJ 282, 190
(1981): Kahn CB, Handbook of Diabetes Mellitus Garland
STPM, 75
(1980): Reeves WG+, BMJ 280, 1500
Lipodystrophy
(2006): Olsovsky J, Vnitr Lek 52(5), 474
(1990): Kohli V+, Indian Pediatr 27, 1120
(1988): Field LM, JAmAcadDermatol19, 570
(1988): Verbenko EV+, Sov Med (Russian) 3, 104
(1987): Goldman JM+, Am J Med 83, 195
(1985): Valenta LJ+, AnnInternMed102, 790
(1984): Campbell IW+, Postgrad Med J 60, 439
(1984): De Mattia G+, Clin Ter (Italian) 111, 169
(1984): Tebuev AM, Pediatriia (Russian) December, 59
(1982): Levandoski LA+, Diabetes Care 5, 6
(1981): Libman E+, Med Pregl (Serbo-Croatian-Roman) 34, 49
(1981): Pisarskaia IV+, Med Sestra (Russian) 40, 54
Lipohypertrophy (1–10%)
(1996): Hauner H+, Exp Clin Endocrinol Diabetes 104, 106
(1990): Schiazza L+, JAmAcadDermatol22, 148
(1989): Zinman B, NEnglJMed321, 363
(1988): McNally PG+, Postgrad Med J 64, 850
(1987): Samadaei A+, JAmAcadDermatol17, 506
(1984): Young RJ+, Diabetes Care 7, 479
(1983): Johnson DA+, Cutis 32, 273
(1982): Mier A+, BMJ 285, 1539
Panniculitis
(1988): Verbenko EV+, Vestn Dermatol Venerol (Russian) 1, 63
Tumors (nodules)
(1981): Galloway JA+, Diabetes Mellitus Bowie 5, 117
INSULIN DETEMIR
Synonym: NN304
Trade name: Levemir (Novo Nordisk)
Indications: Diabetes (Type 1 or 2)
Category: Human Insulin analog, long-acting
Half-life: 5–7 hours
Clinically important, potentially hazardous interactions
with: albuterol, alcohol, clonidine, corticosteroids, danazol,
diuretics, epinephrine, estrogens, isoniazid, lithium, oral
contraceptives, pentamidine, phenothiazines, propranolol,
somatropin, terbutaline, thyroid
Reactions
Skin
Allergic reactions (sic)
(2007): Sola-Gazagnes A+, Lancet 369(9562), 637 (type I and IV)
(2006): Stechemesser L+, Diabetes Care 29(12), 2758 (type III)
(2005): Darmon P+, Diabetes Care 28(12), 2980
Pruritus
Rash (sic)
Other
Injection-site edema
Injection-site erythema
Injection-site inflammation
Injection-site pruritus
Injection-site reactions (3–4%)
(2006): Blumer IR, Diabetes Care 29(4), 946
(2006): No authors listed
, Prescrire Int 15(85), 163
(2004): Jhee SS+, J Clin Pharmacol 44(3), 258
Injection-site urticaria
INSULIN GLARGINE
Trade name: Lantus (Sanofi-Aventis)
Indications: Type 1 & type 2 diabetes
Category: Hormone analog, polypeptide
Half-life: N/A
Clinically important, potentially hazardous interactions
with: alcohol, guanethidine, propranolol
Reactions
INSULIN GLARGINE 297
Skin
Allergic reactions (sic)
Edema
Pruritus
Rash (sic)
Other
Injection-site pain (2.7%)
Lipoatrophy
(2005): Ampudia-Blasco FJ+, Diabetes Care 28(12), 2983
Lipodystrophy