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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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282 IBRITUMOMAB<br />

Hair<br />

Hair – alopecia<br />

(2004): Borghaei H+, Semin Nucl Med 34(1 Suppl 1), 4<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

Chills (24%)<br />

Cough (10%)<br />

Death<br />

Extravasation<br />

(2006): Williams G+, Cancer Biother Radiopharm 21(2), 101<br />

Hypersensitivity<br />

Infections (29%)<br />

(2004): Borghaei H+, Semin Nucl Med 34(1 Suppl 1), 4<br />

(2003): Hagenbeek A, Leuk Lymphoma 44 Suppl 4, S37 (7%)<br />

(2003): Witzig TE+, J Clin Oncol 21(7), 1263 (3%)<br />

Injection-site reactions (sic) (fatal)<br />

Myalgia/Myositis/Myopathy/Myotoxicity (7%)<br />

Pain (13%)<br />

IBUPROFEN<br />

Trade names: Act-3; Actiprofen; Advil (Wyeth); Anco; Apsifen;<br />

Brufen; Ebufac; Genpril; Haltran; Lidifen; Medipren; Midol 220;<br />

Motrin (McNeil); Nuprin; Pamprin; Profen; Proflex; Rufen;<br />

Tabalom; Trendar; Urem; Vicoprofen (Abbott)<br />

Indications: Arthritis, pain<br />

Category: Non-steroidal anti-inflammatory<br />

Half-life: 2–4 hours<br />

Clinically important, potentially hazardous interactions<br />

with: aspirin, boswellia, ciprofibrate, diuretics, methotrexate,<br />

NSAIDs, oxycodone hydrochloride, salicylates, tacrine,<br />

tacrolimus, urokinase<br />

Reactions<br />

Skin<br />

Acute generalized exanthematous pustulosis (AGEP)<br />

(2004): Yesudian PD+, Int J Dermatol 43(3), 208<br />

Angioedema (

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