Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

278 HYDROXYCHLOROQUINE
(1996): Vine JE+, JDermatol23, 357
(1993): Potter B, Cutis 52, 229 (passim)
(1988): Nicolas J-F+, Ann Dermatol Venereol (French) 115, 289
(1987): Friedman SJ, JAmAcadDermatol16, 1256
(1985): Gray RG, J Rheumatol 12, 391
(1982): Abel EA+, JAmAcadDermatol15, 2007
(1982): Luzar MJ, J Rheumatol 9, 462
(1981): Olsen TG, AnnInternMed94, 546
Purpura
Pustules
(1990): Lotem M+, Acta Derm Venereol (Stockh) 70, 250
Rash (sic) (1–10%)
(2006): Mates M+, J Rheumatol 33(4), 814
(2001): Levy RA+, Lupus 10(6), 401
Stevens–Johnson syndrome
(2002): Leckie MJ+, Rheumatology (Oxford) 41(4), 473
Telangiectasia
(2001): Vassallo C+, Clin Exp Dermatol 26(2), 141
Toxic epidermal necrolysis
(2002): Chavez JS, Santiago, Chile, March AAD Poster
(2001): Murphy M+, Clin Exp Dermatol 26(5), 457 (fatal)
Urticaria
(2002): Litt JZ, Beachwood, OH (personal case) (observation)
(1990): Simoneaux PW, Curr Concept Skin Dis Winter, 15
(1980): Koranda FC, JAmAcadDermatol4, 650 (passim)
Vasculitis
(2003): Welsch MJ, J Drugs Dermatol 2(2), 193
Mucosal
Gingival pigmentation
(1992): Veraldi S+, Cutis 49, 281
Mucosal atrophy
(2001): Vassallo C+, Clin Exp Dermatol 26(2), 141
Oral pigmentation
(2005): Fardet L+, Ann Dermatol Venereol 132(8-9 Pt 1), 665
(2001): Vassallo C+, Clin Exp Dermatol 26(2), 141
(1992): Veraldi S+, Cutis 49, 281
(1991): Zic JA+, Arch Dermatol 127, 1037
(1980): Koranda FC, JAmAcadDermatol4, 650 (passim)
Oral ulceration
Stomatitis
(2001): Vassallo C+, Clin Exp Dermatol 26(2), 141
Hair
Hair – alopecia
Hair – pigmentation (bleaching) (1–10%)
(1999): Lecocq P+, Presse Med (French) 28, 741
(1991): Ochsendorf FR+, Hautarzt (German) 42, 140
(1985): Dupré A+, Arch Dermatol 121, 1164
(1980): Koranda FC, JAmAcadDermatol4, 650 (passim)
Nails
Nails – discoloration
(1991): Zic JA+, Arch Dermatol 127, 1037
Nails – pigmentation
(2001): Vassallo C+, Clin Exp Dermatol 26(2), 141
(1980): Koranda FC, JAmAcadDermatol4, 650 (passim)
Eyes
Maculopathy
(1985): Taylor F, Aust Fam Physician 14(8), 744
Ocular toxicity
(2002): Grana Gil+, An Med Interna 19(4), 189
Retinopathy
(2007): Ferreras A+, Arch Soc Esp Oftalmol 82(2), 103
(2006): Tripp JM+, Am J Clin Dermatol 7(3), 171
(2005): Fardet L+, Ann Dermatol Venereol 132(8-9 Pt 1), 665
(2005): Lai TY+, Am J Ophthalmol 140(5), 794
(2005): Tzekov R, Doc Ophthalmol 110(1), 111
(2004): Constable S+, Expert Opin Drug Saf 3(3), 249
Other
Death
(2001): Murphy M+, Clin Exp Dermatol 26(5), 457
Lymphoproliferative disease
(1980): Schechter SL+, Arthritis Rheum 23, 256
Myalgia/Myositis/Myopathy/Myotoxicity
(1998): Richards AJ, J Rheumatol 25, 1642
Porphyria
(1993): Potter B, Cutis 52, 229 (passim)
Rhabdomyolysis
(2005): Creel N+, J Drugs Dermatol 4(2), 225 (with quinacrine)
HYDROXYUREA
Trade names: Droxia (Bristol-Myers Squibb); Hydrea (Bristol-
Myers Squibb); Litalir; Mylocel; Onco-Carbide
Indications: Leukemia, malignant tumors
Category: Antineoplastic; Antiretroviral
Half-life: 3–4 hours
Clinically important, potentially hazardous interactions
with: adefovir, aldesleukin
Reactions
Skin
Acral erythema
(1993): Brincker H+, Cancer Chemother Pharmacol 32, 496
(edema and soreness)
(1992): Parodi A+, G Ital Dermatol Venereol (Italian) 127, 361
(fingers and toes)
(1991): Baack BR+, JAmAcadDermatol24, 457
(1989): Kampmann KK+, Cancer 63, 2482 (passim)
(1984): Sigal M+, Ann Dermatol Venereol (French) 111, 895
(band-like)
(1983): Silver FS+, AnnInternMed98, 675
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)
(2002): Guennoc B+, World Congress Dermatol Poster 0102
Atrophy
(1997): Ena P+, J Geriatr Dermatol 5, 310
Baboon syndrome
(1999): Chowdhury MM+, Clin Exp Dermatol 24, 336
Café-au-lait macules
(2004): Zargari O+, Pediatr Dermatol 21(6), 633
Collodion-like skin
(1996): Gauthier O+, Ann Dermatol Venereol (French) 123, 727
Dermatitis
(2001): Eming SA+, JAmAcadDermatol45, 321
(1984): Sigal M+, Ann Dermatol Venereol (French) 111, 895
Dermatomyositis
(2006): Elliott R+, JDermatologTreat17(1), 59
(2006): Haniffa MA+, Clin Exp Dermatol 31(5), 733
(2006): Zaccaria E+, JDermatologTreat17(3), 176
(2005): Yoshida K+, Clin Exp Dermatol 30(2), 191
(2003): Oh ST+, JAmAcadDermatol49, 339 (2 cases)
(2002): Dacey MJ+, Louisville, KY, March AAD Poster
(2002): Oskay T+, Eur J Dermatol 12(6), 586
(2001): Vassallo C+, Clin Exp Dermatol 26(2), 141
(2000): Kirby B+, Clin Exp Dermatol 25, 256
(1999): Varma S+, Clin Exp Dermatol 24(3), 164
(1998): Suehiro M+, Br J Dermatol 139, 748
(1998): Velez A+, Clin Exp Dermatol 23, 94
(1997): Ena P+, J Geriatr Dermatol 5, 310
(1996): Bahadoran P+, Br J Dermatol 134, 1161
(1995): Senet P+, Br J Dermatol 133, 455
(1995): Weber L+, Hautarzt 46, 717
(1994): Kelly RI+, Australas J Dermatol 35, 61