Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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HYDROMORPHONE Trade names: Dilaudid (Abbott); Dilaudid HP; HydroStat IR; Palladone Indications: Pain Category: Opiate agonist Half-life: 1–3 hours Clinically important, potentially hazardous interactions with: cimetidine Note: This drug has been withdrawn Reactions Skin Diaphoresis Exanthems (1992): de Cuyper C+, Contact Dermatitis 27, 220 (generalized) Pruritus (1–11%) (1996): Halpern SH+, Can J Anaesth 43(6), 595 (1992): Chaplan SR+, Anesthesiology 77, 1090 (11.5%) (1989): Dougherty TB+, Anesth Analg 68(3), 318 (1986): Chestnut DH+, Obstet Gynecol 68(1), 65 Rash (sic) (

278 HYDROXYCHLOROQUINE (1996): Vine JE+, JDermatol23, 357 (1993): Potter B, Cutis 52, 229 (passim) (1988): Nicolas J-F+, Ann Dermatol Venereol (French) 115, 289 (1987): Friedman SJ, JAmAcadDermatol16, 1256 (1985): Gray RG, J Rheumatol 12, 391 (1982): Abel EA+, JAmAcadDermatol15, 2007 (1982): Luzar MJ, J Rheumatol 9, 462 (1981): Olsen TG, AnnInternMed94, 546 Purpura Pustules (1990): Lotem M+, Acta Derm Venereol (Stockh) 70, 250 Rash (sic) (1–10%) (2006): Mates M+, J Rheumatol 33(4), 814 (2001): Levy RA+, Lupus 10(6), 401 Stevens–Johnson syndrome (2002): Leckie MJ+, Rheumatology (Oxford) 41(4), 473 Telangiectasia (2001): Vassallo C+, Clin Exp Dermatol 26(2), 141 Toxic epidermal necrolysis (2002): Chavez JS, Santiago, Chile, March AAD Poster (2001): Murphy M+, Clin Exp Dermatol 26(5), 457 (fatal) Urticaria (2002): Litt JZ, Beachwood, OH (personal case) (observation) (1990): Simoneaux PW, Curr Concept Skin Dis Winter, 15 (1980): Koranda FC, JAmAcadDermatol4, 650 (passim) Vasculitis (2003): Welsch MJ, J Drugs Dermatol 2(2), 193 Mucosal Gingival pigmentation (1992): Veraldi S+, Cutis 49, 281 Mucosal atrophy (2001): Vassallo C+, Clin Exp Dermatol 26(2), 141 Oral pigmentation (2005): Fardet L+, Ann Dermatol Venereol 132(8-9 Pt 1), 665 (2001): Vassallo C+, Clin Exp Dermatol 26(2), 141 (1992): Veraldi S+, Cutis 49, 281 (1991): Zic JA+, Arch Dermatol 127, 1037 (1980): Koranda FC, JAmAcadDermatol4, 650 (passim) Oral ulceration Stomatitis (2001): Vassallo C+, Clin Exp Dermatol 26(2), 141 Hair Hair – alopecia Hair – pigmentation (bleaching) (1–10%) (1999): Lecocq P+, Presse Med (French) 28, 741 (1991): Ochsendorf FR+, Hautarzt (German) 42, 140 (1985): Dupré A+, Arch Dermatol 121, 1164 (1980): Koranda FC, JAmAcadDermatol4, 650 (passim) Nails Nails – discoloration (1991): Zic JA+, Arch Dermatol 127, 1037 Nails – pigmentation (2001): Vassallo C+, Clin Exp Dermatol 26(2), 141 (1980): Koranda FC, JAmAcadDermatol4, 650 (passim) Eyes Maculopathy (1985): Taylor F, Aust Fam Physician 14(8), 744 Ocular toxicity (2002): Grana Gil+, An Med Interna 19(4), 189 Retinopathy (2007): Ferreras A+, Arch Soc Esp Oftalmol 82(2), 103 (2006): Tripp JM+, Am J Clin Dermatol 7(3), 171 (2005): Fardet L+, Ann Dermatol Venereol 132(8-9 Pt 1), 665 (2005): Lai TY+, Am J Ophthalmol 140(5), 794 (2005): Tzekov R, Doc Ophthalmol 110(1), 111 (2004): Constable S+, Expert Opin Drug Saf 3(3), 249 Other Death (2001): Murphy M+, Clin Exp Dermatol 26(5), 457 Lymphoproliferative disease (1980): Schechter SL+, Arthritis Rheum 23, 256 Myalgia/Myositis/Myopathy/Myotoxicity (1998): Richards AJ, J Rheumatol 25, 1642 Porphyria (1993): Potter B, Cutis 52, 229 (passim) Rhabdomyolysis (2005): Creel N+, J Drugs Dermatol 4(2), 225 (with quinacrine) HYDROXYUREA Trade names: Droxia (Bristol-Myers Squibb); Hydrea (Bristol- Myers Squibb); Litalir; Mylocel; Onco-Carbide Indications: Leukemia, malignant tumors Category: Antineoplastic; Antiretroviral Half-life: 3–4 hours Clinically important, potentially hazardous interactions with: adefovir, aldesleukin Reactions Skin Acral erythema (1993): Brincker H+, Cancer Chemother Pharmacol 32, 496 (edema and soreness) (1992): Parodi A+, G Ital Dermatol Venereol (Italian) 127, 361 (fingers and toes) (1991): Baack BR+, JAmAcadDermatol24, 457 (1989): Kampmann KK+, Cancer 63, 2482 (passim) (1984): Sigal M+, Ann Dermatol Venereol (French) 111, 895 (band-like) (1983): Silver FS+, AnnInternMed98, 675 Acute febrile neutrophilic dermatosis (Sweet’s syndrome) (2002): Guennoc B+, World Congress Dermatol Poster 0102 Atrophy (1997): Ena P+, J Geriatr Dermatol 5, 310 Baboon syndrome (1999): Chowdhury MM+, Clin Exp Dermatol 24, 336 Café-au-lait macules (2004): Zargari O+, Pediatr Dermatol 21(6), 633 Collodion-like skin (1996): Gauthier O+, Ann Dermatol Venereol (French) 123, 727 Dermatitis (2001): Eming SA+, JAmAcadDermatol45, 321 (1984): Sigal M+, Ann Dermatol Venereol (French) 111, 895 Dermatomyositis (2006): Elliott R+, JDermatologTreat17(1), 59 (2006): Haniffa MA+, Clin Exp Dermatol 31(5), 733 (2006): Zaccaria E+, JDermatologTreat17(3), 176 (2005): Yoshida K+, Clin Exp Dermatol 30(2), 191 (2003): Oh ST+, JAmAcadDermatol49, 339 (2 cases) (2002): Dacey MJ+, Louisville, KY, March AAD Poster (2002): Oskay T+, Eur J Dermatol 12(6), 586 (2001): Vassallo C+, Clin Exp Dermatol 26(2), 141 (2000): Kirby B+, Clin Exp Dermatol 25, 256 (1999): Varma S+, Clin Exp Dermatol 24(3), 164 (1998): Suehiro M+, Br J Dermatol 139, 748 (1998): Velez A+, Clin Exp Dermatol 23, 94 (1997): Ena P+, J Geriatr Dermatol 5, 310 (1996): Bahadoran P+, Br J Dermatol 134, 1161 (1995): Senet P+, Br J Dermatol 133, 455 (1995): Weber L+, Hautarzt 46, 717 (1994): Kelly RI+, Australas J Dermatol 35, 61

HYDROMORPHONE<br />

Trade names: Dilaudid (Abbott); Dilaudid HP; HydroStat IR;<br />

Palladone<br />

Indications: Pain<br />

Category: Opiate agonist<br />

Half-life: 1–3 hours<br />

Clinically important, potentially hazardous interactions<br />

with: cimetidine<br />

Note: This drug has been withdrawn<br />

Reactions<br />

Skin<br />

Diaphoresis<br />

Exanthems<br />

(1992): de Cuyper C+, Contact Dermatitis 27, 220 (generalized)<br />

Pruritus (1–11%)<br />

(1996): Halpern SH+, Can J Anaesth 43(6), 595<br />

(1992): Chaplan SR+, Anesthesiology 77, 1090 (11.5%)<br />

(1989): Dougherty TB+, Anesth Analg 68(3), 318<br />

(1986): Chestnut DH+, Obstet Gynecol 68(1), 65<br />

Rash (sic) (

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