Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

(1991): Vitris M+, Dakar Med 36(1), 15
(1990): Larpin R+, Presse Med 19(30), 1403
(1988): Hecker E+, Schweiz Med Wochenschr 118(52), 1982 (5
cases)
(1988): Uzan M+, Nephrologie 9(5), 217 (13 cases)
(1981): Palmucci L+, Ital J Neurol Sci 2(3), 275
Serum sickness
Sweat gland necrosis
(1986): Rocamora A+, JDermatol13, 49
HISTRELIN
Trade names: Supprelin (Shire); Vantas (Valera)
Indications: Advanced prostate cancer (palliative treatment),
Control of precocious puberty
Category: Gonadotropin-releasing hormone agonist
Half-life: 4 hours
Clinically important, potentially hazardous interactions
with: N/A
Reactions
Skin
Acne (3–10%)
Angioedema (1–3%)
Diaphoresis (3–10%)
Edema (2%)
Erythema (1%)
Keratoderma (1–3%)
Pallor (1%)
Pruritus (1–3%)
Purpura (2%)
Rash (sic) (7%)
Urticaria (4%)
Eyes
Photophobia (1–3%)
Visual disturbances (2%)
Other
Abdominal pain (>1%)
Chills (>1%)
Cough (3–10%)
Gynecomastia
Hot flashes (2%)
Hypersensitivity
Infections (>1%)
Injection-site edema (45%)
Injection-site erythema (45%)
Injection-site pruritus (45%)
Myalgia/Myositis/Myopathy/Myotoxicity (2–3%)
Pain (>1%)
Upper respiratory infection (3–10%)
HORSE CHESTNUT (BARK, FLOWER, LEAF, SEED) 271
HOPS
Scientific name: Humulus lupulus
Family: Cannabaceae
Trade and other common names: Hop Strobile;
Hopfenzapfen; Houblon
Category: Cannabinoid; Phytoestrogen; Sedative
Purported indications and other uses: Insomnia, anxiety,
diuretic, appetite stimulant. Flavoring in foods and beverages
Half-life: N/A
Reactions
Skin
Urticaria
(2002): Estrada JL+, Contact Dermatitis 46(2), 127
(2002): Pradalier A+, Allerg Immunol (Paris) 34(9), 330
Other
Fever
(2002): Pradalier A+, Allerg Immunol (Paris) 34(9), 330
HORSE CHESTNUT (BARK,
FLOWER, LEAF, SEED)*
Scientific name: Aesculus hippocastanum
Family: Hippocastanaceae
Trade and other common names: Buckeye; Hippocastani;
Marron Europeen; Venostat; Venostatin Retard
Category: Diuretic
Purported indications and other uses: Oral: malaria,
dysentery, tinnitus, pancreatitis, cough, arthritis, rheumatism,
chronic venous insufficiency. Topical: lupus, skin ulcers eczema,
phlebitis, varicose veins, hemorrhoids, rectal problems
Half-life: N/A
Clinically important, potentially hazardous interactions
with: heparin, NSAIDs, ticlopidine, warfarin
Reactions
Skin
Adverse effects (sic) (mild)
(2002): Pittler MH+, Cochrane Database Syst Rev (1), CD003230
Dermatitis (flower)
(1980): Comaish JS+, Contact Dermatitis 6(2), 150
Purpura
(1998): Brinker F, Herb Contraindications & Interactions Eclectic
Medical Publications (2nd Ed)
Other
Anaphylactoid reactions/Anaphylaxis (seed)
(1998): Gruenwald J+, PDR for Herbal Medicines. 1st ed
Montvale, NJ: Medical Economics Company, Inc
*Note: The active ingredient is a toxic glycoside, escin