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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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HEPARIN<br />

Trade names: Calcilean; Calciparin; Caprin; Hep-Flush (Wyeth);<br />

Hepalean; Heparin-Leo; Heparine; Liquemin; Uniparin<br />

Indications: Venous thrombosis, pulmonary embolism<br />

Category: Anticoagulant; Heparinoid<br />

Half-life: 1.5 hours<br />

Clinically important, potentially hazardous interactions<br />

with: aspirin, bivalirudin, butabarbital, capsicum, ceftobiprole,<br />

danaparoid, dong quai, ginger, horse chestnut (bark, flower,<br />

leaf, seed), palifermin, red clover, salicylates, tirofiban<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (1–10%)<br />

(2004): Tiu A+, NZMedJ117(1204), U1126<br />

(1997): Hermes B+, Acta Derm Venereol 77, 35<br />

Angioedema (

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