Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

266 HENNA
HENNA*
Scientific names: Lawsonia alba; Lawsonia inermis
Family: Lythraceae
Trade and other common names: Alcanna; Egyptian Privet;
Hinai; Hinna; Inai; Jamaica Kina; Lawsone (2-hydroxy-
1:4naphthaquione); Mehandi; Mehndi
Category: Anti-inflammatory
Purported indications and other uses: Analgesic, antipyretic,
seborrheic dermatitis, fungal infections, gastrointestinal ulcers,
sunscreen, dandruff, scabies, headache, jaundice, decorative
tattoos, Used in cosmetics, body paint, hair dyes, hair care
products
Half-life: N/A
*Note: Black Henna is Henna plus paraphenylenediamine (PPD).
PPD is added to henna to make it stain black. PPD is a transdermal
toxin and may be used alone as hair dye or to stain skin black. Other
products called ‘black henna’ may have indigo or food dyes added,
and are generally not harmful to the skin
Reactions
Skin
Adverse effects (sic)
(2003): De Souza B+, Plast Reconstr Surg 111(7), 2487
(2003): Wolf R+, Dermatol Online J 9(1), 3
Allergic reactions (sic)
(2000): US Food and Drug Administration, Office of Cosmetics
and Colors Fact Sheet
Angioedema
(2006): Gulen F+, Minerva Pediatr 58(6), 583
Bullous dermatitis
Burning
Dermatitis
(2007): Reyes Balaguer J+, Med Clin (Barc) 128(8), 318
(2003): Leggiadro RJ+, JPediatr142(5), 586
(2003): Wolf R+, Dermatol Online J 9(1), 3
(2002): Marcoux D+, Pediatr Dermatol 19(6), 498
(2002): Neri I+, Pediatr Dermatol 19(6), 503
(2002): Pegas JR+, J Investig Allergol Clin Immunol 12(1), 62
(2002): Temesvari E+, Contact Dermatitis 47(4), 240
(2002): van Zuuren+, Ned Tijdschr Geneeskd 146(28), 1332
(2001): Di Lando A+, Am J Contact Dermat 12(3), 186
(2001): Kulkarni PD+, Cutis 68(3):187, 229 (+PPD)
(2001): Lauchl S+, Swiss Med Wkly 131, 199 (+PPD)
(2001): Onder M+, Int J Dermatol 40(9), 577 (+PPD)
(2001): Oztass MO+, J Eur Acad Dermatol Venereol 15(1), 91
(2001): Thami GP+, Allergy 56(10), 1013
(2000): Le Coz CJ+, Arch Dermatol 136(12), 1515 (+PPD)
(2000): Lyon MJ+, Arch Dermatol 136(1), 124
(2000): Nikkels AF+, J Eur Acad Dermatol Venereol 15(2), 140
(+PPD)
(2000): Raison-Peyron N+, Ann Dermatol Venereol 127(12), 1083
(+PPD)
(2000): Sidbury R+, Am J Contact Dermat 11(3), 182 (+PPD)
(2000): Tosti A+, Contact Dermatitis 42(6), 356
(1999): Gallo R+, Contact Dermatitis 40(1), 57
(1999): Lestringant GG+, Br J Dermatol 141(3), 598
(1999): Lewin PK, CMAJ 160(3), 310
(1998): Nigam PK+, Contact Dermatitis 18(1), 55
(1998): Wakelin SH+, Contact Dermatitis 39(2), 92 (+PPD)
(1997): Downs AMR+, Br Med J 315, 1772 (+PPD)
(1997): Etienne A+, Contact Dermatitis 37(4), 183
(1997): Garcia Ortiz JC+, Int Arch Allergy Immunol 114(3), 298
(1996): al-Sheik OA+, Int J Dermatol 35(7), 493
(1992): Wantke F+, Contact Dermatitis 27(5), 346 (from Azo
dyes)
(1986): Gupta BN+, Contact Dermatitis 15(5), 303
(1980): Pasricha JS+, Contact Dermatitis 6(4), 288
Eczema
(2002): Suarez Fernandez R+, Allergol Immunopathol (Madr)
30(5), 292
Edema
(2002): Marcoux D+, Pediatr Dermatol 19(6), 498
(2001): Lauchl S+, Swiss Med Wkly 131, 199 (+PPD)
(2001): Wohrl S+, Eur Acad Dermatol Venereol 15(5), 470
(+PPD)
Erythema
(2002): Marcoux D+, Pediatr Dermatol 19(6), 498
(2002): Schultz E+, Int J Dermatol 41(5), 301
(2001): Lauchl S+, Swiss Med Wkly 131, 199 (+PPD)
Erythema multiforme
(2001): Jappe U+, Contact Dermatitis 45(4), 249 (+PPD)
Keloid
(1999): Lewkin PK, CMAJ 160(3), 310
Leukoderma
(2007): Valsecchi R+, Contact Dermatitis 56(2), 108
Lichenoid eruption
(2002): Chung WH+, Arch Dermatol 138(1), 88 (+PPD)
(2002): Ferrer P+, Cosmetic Dermatology 15, 11
(2002): Schultz E+, Int J Dermatol 41(5), 301
(2000): Rubegni P+, Contact Dermatitis 42(2), 117
Photosensitivity
Pigmentation
(2002): Marcoux D+, Pediatr Dermatol 19(6), 498
(2002): van Zuuren+, Ned Tijdschr Geneeskd 146(28), 1332
(2001): Wohrl S+, J Eur Acad Dermatol Venereol 15(5), 470
(+PPD)
Pruritus
(2002): Suarez Fernandez+, Allergol Immunopathol (Madr)
30(5), 292
(2001): Lauchl S+, Swiss Med Wkly 131, 199 (+PPD)
(2000): Sidbury R+, Am J Contact Dermat 11(3), 182 (+PPD)
Psoriasis
(1991): El-Gammal SY, Bull Indian Inst Hist Med Hyderabad
121(2), 125
Rash (sic)
Sensitivity
(2004): Lim SP+, Br J Dermatol 151(6), 1271 (+PPD)
Urticaria
(2006): Gulen F+, Minerva Pediatr 58(6), 583
(1997): Downs AMR+, Br Med J 315, 1722
(1996): Majoie IM+, Am J Contact Dermat 7(1), 38
Other
Death
(2001): Devecioglu C+, Turk J Pediatr 43(1), 65
(2001): Raupp P+, Arch Dis Child 85(5), 411
(1992): Sir Hashim M+, Ann Trop Paediatr 12(1), 3 (+PDD)
Hypersensitivity
(2001): Bolhaar ST+, Allergy 56(3), 248
(2001): Kulkarni PD+, Cutis 68(3), 187 (+PPD)
(2000): Lyon MJ+, Arch Dermatol 136(1), 124
(2000): Nikkels AF+, J Eur Acad Dermatol Venereol 15(2), 140
(+PPD)
(1996): Abdulla KA+, Lancet 348(9028), 658 (+PPD)
(1996): Majoie IM+, Am J Contact Dermat 7(1), 38
(1996): Ozsoylu S, Lancet 348(9035), 1173
(1982): Starr JC+, Ann Allergy 48(2), 98
Side effects (sic)
(2000): Ernst E, Br J Dermatol 143(5), 923
Note: Adverse side effects to pure henna are rare; those reported
above may be due to additives. Henna tattoos were popularized by
Madonna. Her black patterns, however, were created with body
paint, not henna