Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Peripheral edema (>10%) Purpura Urticaria Vasculitis Mucosal Glossitis (5%) Sialorrhea Xerostomia (1–10%) Hair Hair – alopecia Other Myalgia/Myositis/Myopathy/Myotoxicity GUANFACINE Trade names: Entulic; Estulic; Tenex (ESP) Indications: Hypertension Category: Adrenergic alpha-receptor agonist Half-life: 10–30 hours Reactions Skin Dermatitis (

264 HEMOPHILUS B VACCINE Other Anaphylactoid reactions/Anaphylaxis Fever (1991): MMWR Recomm Rep 40(RR), 1 Hypersensitivity Injection-site edema (1991): MMWR Recomm Rep 40(RR), 1 Injection-site induration Injection-site pain (1993): de Montalembert M+, Arch Fr Pediatr 50(10), 863 HALCINONIDE Trade name: Halog (Bristol-Myers Squibb) Indications: Dermatoses Category: Corticosteroid, topical Half-life: N/A Clinically important, potentially hazardous interactions with: live vaccines Reactions Skin Acne Burning (1981): Guenther L+, Cutis 28(4), 461 (1980): Akers WA, Arch Dermatol 116(7), 786 Irritation (1981): Guenther L+, Cutis 28(4), 461 (1980): Akers WA, Arch Dermatol 116(7), 786 Pigmentation Pruritus (1981): Guenther L+, Cutis 28(4), 461 (1980): Akers WA, Arch Dermatol 116(7), 786 Rash (sic) Xerosis (1980): Akers WA, Arch Dermatol 116(7), 786 Other Hypersensitivity (1986): Reitamo S+, JAmAcadDermatol14(4), 582 Infections HALOBETASOL Trade name: Ultravate (Westwood Squibb) Indications: Dermatoses Category: Corticosteroid, topical Half-life: N/A Clinically important, potentially hazardous interactions with: live vaccines Reactions Skin Adverse effects (sic) (1991): Blum G+, JAmAcadDermatol25(6), 1153 (1991): Brunner N+, JAmAcadDermatol25(6), 1160 (rare) (1991): Datz B+, JAmAcadDermatol25(6), 1157 (5%) (1991): Goldberg B+, JAmAcadDermatol25(6), 1145 (7%) (1991): Herz G+, JAmAcadDermatol25(6), 1166 (2%) Atrophy (1991): Herz G+, JAmAcadDermatol25(6), 1166 (1 case) Burning Erythema Pruritus (1991): Yawalkar SJ+, JAmAcadDermatol25(6), 1163 (1990): Watson WA+, Pharmacotherapy 10(2), 107 (2 cases) Stinging Xerosis (1991): Yawalkar SJ+, JAmAcadDermatol25(6), 1163 (1 case) HALOMETASONE Trade name: Sicorten Indications: Dermatoses Category: Corticosteroid, topical Half-life: N/A Clinically important, potentially hazardous interactions with: live vaccines Reactions Skin Adverse effects (sic) (1983): Maeder E+, JIntMedRes11, 48 (mild) Pruritus (1983): Weitgasser H+, JIntMedRes11, 34 (4%) Pustules (1983): Galbiati G+, JIntMedRes11, 31 (1 case) HALOPERIDOL Trade names: Dozic; Duraperidol; Haldol (Ortho-McNeil); Haloper; Peridol; Seranace; Serenace Indications: Psychoses, Tourette’s disorder Category: Antipsychotic, butyrophenone Half-life: 20 hours Clinically important, potentially hazardous interactions with: benztropine, eucalyptus, fluoxetine, lithium, methotrexate, propranolol Reactions Skin Acne Cellulitis (1982): Sacks HS, Hosp Pract Off Ed 17, 179 Dermatitis (

Peripheral edema (>10%)<br />

Purpura<br />

Urticaria<br />

Vasculitis<br />

Mucosal<br />

Glossitis (5%)<br />

Sialorrhea<br />

Xerostomia (1–10%)<br />

Hair<br />

Hair – alopecia<br />

Other<br />

Myalgia/Myositis/Myopathy/Myotoxicity<br />

GUANFACINE<br />

Trade names: Entulic; Estulic; Tenex (ESP)<br />

Indications: Hypertension<br />

Category: Adrenergic alpha-receptor agonist<br />

Half-life: 10–30 hours<br />

Reactions<br />

Skin<br />

Dermatitis (

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