Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

260 GRANULOCYTE COLONY-STIMULATING FACTOR (GCSF)
Hair
Hair – alopecia (>10%)
(1990): Lazarus H+, Proc Am Soc Clin Oncol 9, 15
Eyes
Keratitis
(2007): Fraunfelder FW+, Cornea 26(3), 368
Other
Abdominal pain
(2002): Otaibi AA+, JPediatrSurg37(5), 770
Anaphylactoid reactions/Anaphylaxis (5%)
(2002): Cesaro S+, Haematologica 87(8), 35 (5%)
(2000): Milkovich G+, Pharmacotherapy 20(12), 1432
(1999): Facon T+, Blood 94(4), 1218
(1997): Moskowitz CH+, Blood 89(9), 3136
Injection-site urticaria
(1995): Scott GA, Am J Dermatopathol 17, 107
Lymphoproliferative disease
(1994): De la Rubia J+, Bone Marrow Transplantation 14, 475
(1994): Kawach Y+, Leukemia and Lymphoma 13, 509
Myalgia/Myositis/Myopathy/Myotoxicity (>10%)
(2002): Sevilla J+, Bone Marrow Transplant 30(7), 417
Panniculitis (necrotizing)
(2000): Dereure O+, Br J Dermatol 142, 834
Systemic reactions
(1999): Alvarado Ibarra ML+, Rev Invest Clin 51(2), 77
GRAPEFRUIT JUICE
Scientific names: Citrus decumana; Citrus maxima; Citrus paradisi
Family: Rutaceae
Trade and other common names: Paradisapfel; Pomelo;
Toronja
Category: Food supplement
Purported indications and other uses: atherosclerosis, anticancer
agent, cholesterol reduction, psoriasis, weight reduction.
Source of potassium, vitamin C, and fiber
Half-life: N/A
Clinically important, potentially hazardous interactions
with: alprazolam, amiodarone, buspirone, corticosteroids,
eplerenone, felodipine, itraconazole, lapatinib, lercanidipine,
lovastatin, midazolam, nifedipine, nisoldipine, pimozide,
prednisolone, prednisone, propafenone, red rice yeast,
repaglinide, simvastatin, tacrolimus, tacrolimus, terfenadine,
warfarin
Reactions
Skin
Urticaria
(2006): Kumar A+, Clin Rev Allergy Immunol 30(1), 61
Other
Adverse effects (sic)
(2003): Bailey DG+, Clin Pharmacol Ther 73(6), 529 (with
felodipine) (1 case)
Rhabdomyolysis
(2002): Sardi A+, Ann Ital Med Int 17(2), 126 (with licorice) (1
case)
Note: Many authors consider that, because cytochrome P450 is
inhibited by grapefruit juice, any drugs requiring this for action may
interact with grapefruit juice. The list of other possible interactions
may include: amlodipine, atorvastatin, carbamazepine, carvedilol,
cisapride, clomipramine, cyclosporine, dextromethorphan, diazepam,
erythromycin, ethinyl estradiol, losartan, nicardipine, nifedipine,
nisoldipine, nimodipine, praziquantel, quinidine, scopolamine,
sertraline, sibutramine, sildenafil, theophylline, verapamil
GREEN TEA
Scientific names: Camellia sinensis; Camellia thea; Camellia
theifera; Thea bohea; Thea sinensis; Thea viridis
Family: Theaceae
Trade and other common names: Chinese tea
Category: Food supplement; TNF inhibitor; Xanthine alkaloid
Purported indications and other uses: Improving cognitive
performance, stomach disorders, nausea, vomiting, diarrhea,
anticancer, headaches, Crohn’s disease. Topical: soothe sunburn,
bleeding gums, reduce sweating
Half-life: N/A
Clinically important, potentially hazardous interactions
with: warfarin
Reactions
Skin
Rosacea
(2007): Lleonart R+, Allergy 62(1), 89
Other
Hepatotoxicity