Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

258 GOLDENSEAL
GOLDENSEAL
Scientific name: Hydrastis canadensis
Family: Ranunculaceae
Trade and other common names: Eye balm; Goldenroot;
Ground raspberry; Huanglian; Indian dye; Jaundice root; Orange
root; Warnera; Yellow puccoon; Yellow root
Category: Immunomodulator; Isoquinolone alkaloid
Purported indications and other uses: Oral: Anorexia, fever,
hemorrhoids, hemorrhage, liver disorders, menstrual disorders,
rhinitis, upper respiratory tract infections, urinary tract infections.
Topical: Acne, conjunctivitis, dandruff, earache, eczema, eye
inflammation, herpes, itching, mouthwash, rash, ringworm,
tinnitus, wounds
Half-life: N/A
Reactions
Skin
Photosensitivity
(2003): Palanisamy A+, J Toxicol Clin Toxicol 41(6), 865 (with
ginseng, bee pollen)
Phototoxicity
(2001): Inbaraj JJ+, Chem Res Toxicol 14(11), 1529
Mucosal
Mucosal irritation
Other
Death (overdose)
GOSERELIN
Trade names: Prozoladex; Zoladex (AstraZeneca)
Indications: Breast and prostate carcinoma, endometriosis
Category: Gonadotropin-releasing hormone agonist
Half-life: 5 hours
Reactions
Skin
Diaphoresis (1–10%)
(2006): Nikolov A+, Akush Ginekol (Sofiia) 45(4), 13
Edema (1–10%)
Rash (sic) (1–10%)
Urticaria
Mucosal
Vaginal dryness
(2006): Nikolov A+, Akush Ginekol (Sofiia) 45(4), 13
Hair
Hair – alopecia
(2002): Jonat W+, J Clin Oncol 20(24), 4628
Eyes
Cataract
(2007): Al-Enezi A+, Med Princ Pract 16(2), 161
Other
Anaphylactoid reactions/Anaphylaxis
(2006): Lam C+, Pharmacotherapy 26(12), 1811 (recurrent)
(1996): Raj SG+, Am J Med Sci 312, 187
Chills
Gynecomastia (>10%)
Hot flashes (>10%)
(2006): Nikolov A+, Akush Ginekol (Sofiia) 45(4), 13
(2005): Franco S+, Acta Med Port 18(2), 123
(2002): Gommersall LM+, Expert Opin Pharmacother 3(12), 1685
(1993): Bressler LR+, Ann Pharmacother 27, 182
Hypersensitivity
(1996): Raj SG+, Am J Med Sci 312, 187
Injection-site pain (1–10%)
Injection-site papules & nodules
(2002): Cunha AP+, World Congress Dermatol Poster, 0095
GRANISETRON
Trade names: Kevatril; Kytril (Roche)
Indications: Chemotherapy-related emesis
Category: 5-HT3 antagonist; Serotonin type 3 receptor
antagonist
Half-life: 3–4 hours; cancer patients: 10–12 hours
Reactions
Skin
Allergic reactions (sic)
(2001): Kanny G+, J Allergy Clin Immunol 108(6), 1059
Exanthems
Rash (sic)
Urticaria
Mucosal
Xerostomia
(2005): Moreno J+, Support Care Cancer 13(10), 850 (11%)
Hair
Hair – alopecia (3%)
Other
Anaphylactoid reactions/Anaphylaxis
Hot flashes (