Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

GLYBURIDE
Synonyms: glibenclamide; glybenclamide
Trade names: Albert (Glyburide); Daonil; Diabeta (Sanofi-
Aventis); Euglucan; Euglucon; Glimel; Glucal; Glucovance (Bristol-
Myers Squibb); Glynase (Pfizer); Hemi-Daonil; Med-Glibe;
Micronase (Pfizer); Miglucan; Norboral
Indications: Non-insulin dependent diabetes type ll
Category: Sulfonylurea
Half-life: 5–16 hours
Clinically important, potentially hazardous interactions
with: bosentan
Glucovance is glyburide and metformin
Reactions
Skin
Allergic reactions (sic) (0.21%)
(1986): Bigby M+, JAMA 256, 3358
Angioedema
Bullous dermatitis
(1981): Wongpaitoon V+, Postgrad Med J 57, 244
Eczema
Erythema (1–5%)
(1988): Chee Ching S, Photodermatol 5, 42
Exanthems (1–5%)
Exfoliative dermatitis
Lichenoid eruption
(2005): Fox GN+, Cutis 76(1), 41
Linear IgA dermatosis
(2003): Avci O+, JAmAcadDermatol48(2), 299 (passim)
(1983): Väätäinen N+, Acta Derm Venereol (Stockh) 63, 169
Pemphigus
(2005): Goldberg I+, Acta Dermatovenerol Croat 13(3), 153
(1993): Paterson AJ+, JOralPatholMed22, 92
Peripheral edema
(1988): Berova N+, Dermatol Monatsschr (German) 174, 50
Photosensitivity (1–10%)
(1995): Fujii S+, Am J Hematol 50, 223
(1994): Shelley WB+, Cutis 53, 287 (observation)
(1994): Shelley WB+, Cutis 53, 77 (observation)
(1988): Chee-Ching S, Photodermatology 5, 42
(1988): Sun CC, Photodermatol 5, 42
(1987): Henrietta G, Nursing 17, 56
Pruritus (1–10%)
(1988): Chee Ching S, Photodermatol 5, 42
(1987): Physicians Drug Alert 7, 71
Psoriasis
(1988): Milner JE, The Schoch Letter 38(5), Item 64 (obervation)
(1987): Goh CL, Australas J Dermatol 28, 30
Purpura
(1986): Dickey W+, BMJ 293, 823
(1983): Väätäinen N+, Acta Derm Venereol (Stockh) 63, 169
Rash (sic) (1–10%)
Urticaria (1–5%)
(1994): Shelley WB+, Cutis 53, 77 (observation)
(1991): Chichmanian RM+, Therapie (French) 46, 163
(1986): Jordan NS+, Hosp Pharm 21, 462
(1986): Kure J, NC Med J 47, 149
Vasculitis
(2003): Bukhalo M+, Cutis 71(3), 235
(1986): Dickey W+, BMJ 293, 823
(1980): Ingelmo M+, Med Clin (Barc) (Spanish) 75, 306
Vesiculobullous eruption
(1993): Landor M+, Ann Allergy 70, 196
Eyes
Eyelid edema
(1985): Yitalo P+, Arzneimittelforsch (German) 35, 1596
Other
Hypersensitivity (generalized)
Myalgia/Myositis/Myopathy/Myotoxicity
Porphyria cutanea tarda
*Note: Glyburide is a sulfonamide and can be absorbed systemically.
Sulfonamides can produce severe, possibly fatal, reactions such as
toxic epidermal necrolysis and Stevens–Johnson syndrome
GLYCOPYRROLATE
Trade names: Gastrodyn; Robinul (First Horizon); Sroton;
Strodin
Indications: Duodenal ulcer, irritable bowel syndrome
Category: Anticholinergic; Muscarinic antagonist; Nondepolarizing
muscle relaxant
Half-life: N/A
Clinically important, potentially hazardous interactions
with: anticholinergics, arbutamine
Reactions
Skin
Allergic reactions (sic)
Photosensitivity (1–10%)
Rash (sic) (10%)
Mucosal
Xerostomia (>10%)
(2001): Patel PS+, Spec Care Dentist 21(5), 176
(1999): Marples IL+, Br J Anaesth 83(3), 537
(1999): Wolff MS+, Arch Oral Biol 44(2), 97
(1993): Gorcsan J+, JAmSocEchocardiogr6(2), 200
Eyes
Mydriasis
(2006): Izadi S+, J Neuroophthalmol 26(3), 232
Other
Anhidrosis
Injection-site irritation (>10%)
GOLD and GOLD COMPOUNDS
Generic names:
Auranofin
Trade name: Ridaura (GSK)
Aurothioglucose
Trade name: Solganal (Schering)
Gold sodium thiomalate (sodium aurothiomalate)
Trade name: Myochrysine (Merck)
Indications: Rheumatoid arthritis
Category: Disease-modifying antirheumatic
Half-life: 5 days
Skin
Acne
GOLD AND GOLD COMPOUNDS 255
Reactions