Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Hair Hair – alopecia (>2%) Nails Nails – changes (>2%) Eyes Xerophthalmia Other Anaphylactoid reactions/Anaphylaxis (2005): Rauschka H+, Neurology 64(8), 1481 Chills (4%) Cough (>2%) Embolia cutis medicamentosa (Nicolau syndrome) (2003): Gaudez C+, Rev Neurol (Paris) 159(5), 571 Facial numbness Gynecomastia Infections (50%) Injection-site abscess Injection-site atrophy Injection-site bleeding (5%) Injection-site ecchymoses (>2%) Injection-site edema Injection-site erythema (66%) (2005): Nolden S+, Mult Scler 11(2), 245 (2001): Ziemssen T+, Drug Saf 24(13), 979 Injection-site fibrosis Injection-site hematoma Injection-site hypersensitivity Injection-site induration (13%) (2005): Nolden S+, Mult Scler 11(2), 245 (2004): Soos N+, Am J Clin Dermatol 5(5), 357 (2001): Ziemssen T+, Drug Saf 24(13), 979 Injection-site inflammation (49%) (2001): Ziemssen T+, Drug Saf 24(13), 979 Injection-site lipoatrophy (2004): Edgar CM+, Can J Neurol Sci 31(1), 58 (45%) (2004): Soos N+, Am J Clin Dermatol 5(5), 357 Injection-site pain (73%) (2005): Nolden S+, Mult Scler 11(2), 245 Injection-site panniculitis (2004): Soos N+, Am J Clin Dermatol 5(5), 357 Injection-site pigmentation Injection-site pruritus (40%) (2005): Nolden S+, Mult Scler 11(2), 245 Injection-site reactions (6–67%) (2006): Gordon PH+, Neurology 66(7), 1117 (2005): Fiore AP+, Arq Neuropsiquiatr 63(3B), 738 (2004): Prescrire Int 13(69), 10 (2002): Flechter S+, JNeurolSci197(1), 51 (67%) (2002): Ziemssen T+, Nervenarzt 73(4), 321 Injection-site urticaria (5%) Lipoatrophy (2001): Hwang L+, Cutis 68(4), 287 (1999): Drago F+, Arch Dermatol 135(10), 1277 (localized) Lipomatosis Lymphedema Moon face Myalgia/Myositis/Myopathy/Myotoxicity (>2%) Pain (28%) Panniculitis (2006): Soares Almeida LM+, JAmAcadDermatol55(6), 968 Serum sickness Tumors GLIMEPIRIDE* Trade name: Amaryl (Sanofi-Aventis) Indications: Non-insulin dependent diabetes type ll Category: Sulfonylurea Half-life: 5–9 hours Reactions Skin Allergic reactions (sic) (

254 GLIPIZIDE Purpura Rash (sic) (1–10%) Stevens–Johnson syndrome (2006): Cheng JB+, Dermatitis 17(1), 36 Urticaria (1–10%) Mucosal Oral lichen planus (1990): Lamey PJ+, Oral Surg Oral Med Oral Path 70, 184 Other Myalgia/Myositis/Myopathy/Myotoxicity (

Hair<br />

Hair – alopecia (>2%)<br />

Nails<br />

Nails – changes (>2%)<br />

Eyes<br />

Xerophthalmia<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

(2005): Rauschka H+, Neurology 64(8), 1481<br />

Chills (4%)<br />

Cough (>2%)<br />

Embolia cutis medicamentosa (Nicolau syndrome)<br />

(2003): Gaudez C+, Rev Neurol (Paris) 159(5), 571<br />

Facial numbness<br />

Gynecomastia<br />

Infections (50%)<br />

Injection-site abscess<br />

Injection-site atrophy<br />

Injection-site bleeding (5%)<br />

Injection-site ecchymoses (>2%)<br />

Injection-site edema<br />

Injection-site erythema (66%)<br />

(2005): Nolden S+, Mult Scler 11(2), 245<br />

(2001): Ziemssen T+, <strong>Drug</strong> Saf 24(13), 979<br />

Injection-site fibrosis<br />

Injection-site hematoma<br />

Injection-site hypersensitivity<br />

Injection-site induration (13%)<br />

(2005): Nolden S+, Mult Scler 11(2), 245<br />

(2004): Soos N+, Am J Clin Dermatol 5(5), 357<br />

(2001): Ziemssen T+, <strong>Drug</strong> Saf 24(13), 979<br />

Injection-site inflammation (49%)<br />

(2001): Ziemssen T+, <strong>Drug</strong> Saf 24(13), 979<br />

Injection-site lipoatrophy<br />

(2004): Edgar CM+, Can J Neurol Sci 31(1), 58 (45%)<br />

(2004): Soos N+, Am J Clin Dermatol 5(5), 357<br />

Injection-site pain (73%)<br />

(2005): Nolden S+, Mult Scler 11(2), 245<br />

Injection-site panniculitis<br />

(2004): Soos N+, Am J Clin Dermatol 5(5), 357<br />

Injection-site pigmentation<br />

Injection-site pruritus (40%)<br />

(2005): Nolden S+, Mult Scler 11(2), 245<br />

Injection-site reactions (6–67%)<br />

(2006): Gordon PH+, Neurology 66(7), 1117<br />

(2005): Fiore AP+, Arq Neuropsiquiatr 63(3B), 738<br />

(2004): Prescrire Int 13(69), 10<br />

(2002): Flechter S+, JNeurolSci197(1), 51 (67%)<br />

(2002): Ziemssen T+, Nervenarzt 73(4), 321<br />

Injection-site urticaria (5%)<br />

Lipoatrophy<br />

(2001): Hwang L+, Cutis 68(4), 287<br />

(1999): Drago F+, Arch Dermatol 135(10), 1277 (localized)<br />

Lipomatosis<br />

Lymphedema<br />

Moon face<br />

Myalgia/Myositis/Myopathy/Myotoxicity (>2%)<br />

Pain (28%)<br />

Panniculitis<br />

(2006): Soares Almeida LM+, JAmAcadDermatol55(6), 968<br />

Serum sickness<br />

Tumors<br />

GLIMEPIRIDE*<br />

Trade name: Amaryl (Sanofi-Aventis)<br />

Indications: Non-insulin dependent diabetes type ll<br />

Category: Sulfonylurea<br />

Half-life: 5–9 hours<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (

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