Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(1996): Merlob P+, Cutis 57, 429 (neonatal orbital) (1996): Munoz-Bellido FJ+, Allergy 51, 758 (1989): van Ketel WG+, Contact Dermatitis 20, 303 (1988): Robinson PM, JLaryngolOtol102, 577 Eczema (1988): Ghadially R+, JAmAcadDermatol19, 428 Edema (1–10%) Erythema (1–10%) Exanthems (

252 GINKGO BILOBA Mucosal Rectal burning Stomatitis Eyes Hyphema (2002): Schneider C+, JFrOphtalmol25(7), 731 Ocular adverse effects (2004): Fraunfelder FW, Am J Ophthalmol 138(4), 639 Other Death (2005): Kupiec T+, J Anal Toxicol 29(7), 755 (with valproic acid) Phlebitis Note: Ginkgo biloba is the oldest living tree species in the world. Ginkgo is the most frequently prescribed herbal medicine in Germany GINSENG Scientific name: Panax ginseng Family: Araliaceae Trade and other common names: Asian Ginseng; Asiatic Ginseng; Chinese Ginseng; Japanese Ginseng; Jintsam; Korean Ginseng; Korean Red; Ninjin; Red Ginseng; Ren She; Sang; Seng Category: Immunomodulator Purported indications and other uses: General tonic, improving stamina, cognitive function, concentration, diuretic, antidepressant, gastritis, neurasthenia, impotence, fever, hangover, cancer, cardiovascular diseases Half-life: N/A Clinically important, potentially hazardous interactions with: alcohol, aspirin, caffeine, digoxin, olmesartan, phenelzine, squill, tamoxifen, ticlopidine, warfarin Reactions Skin Adverse effects (sic) (2002): Ellis JM+, Ann Pharmacother 36(3), 375 (2002): Ernst E, AnnInternMed136(1), 42 (2002): Haller CA+, Adverse Drug React Toxicol Rev 21(3), 143 Allergic reactions (sic) Burning (sensation) (1999): Choi HK+, Int J Impot Res 11(5), 261 Edema Pruritus Stevens–Johnson syndrome (2001): Boniel T+, Harefuah 140(8), 780 (1996): Dega H+, Lancet 313, 756 Other Gynecomastia (1999): Palop V+, Med Clin (Barc) 112(19), 758 Side effects (sic) (2002): Tesch BJ, Dis Mon Oct 48(10), 671 Note: Ginseng has been used for medicinal purposes for more than 2000 years. Approximately 6,000,000 Americans use it regularly GLATIRAMER* Trade name: Copaxone (Teva) Indications: Multiple sclerosis Category: Immunomodulator Half-life: N/A Clinically important, potentially hazardous interactions with: Hemophilus B vaccine. None *Note: Also known as Copolymer-1 Reactions Skin Acne (>2%) Allergic reactions (sic) Angioedema Atrophy Cellulitis Cyst (2%) Dermatitis Diaphoresis (15%) (2004): Munari L+, Cochrane Database Syst Rev (1), CD004678 Eczema Edema (3%) Erythema (4%) Erythema nodosum Exanthems Facial edema (6%) Fungal dermatitis Furunculosis Herpes simplex (4%) Herpes zoster Lupus erythematosus Lymphocytic infiltration (2005): Nolden S+, Mult Scler 11(2), 245 Nodular eruption (2%) Peripheral edema (7%) Photosensitivity Pigmentation Pruritus (185) Psoriasis Purpura Pustules Rash (sic) (18%) Striae Urticaria Vesiculobullous eruption Xanthomas Xerosis Mucosal Gingival bleeding Glossodynia Oral candidiasis Oral ulceration Oral vesiculation (6%) Stomatitis Tongue edema Tongue pigmentation Ulcerative stomatitis Vaginitis Xerostomia (>2%)

(1996): Merlob P+, Cutis 57, 429 (neonatal orbital)<br />

(1996): Munoz-Bellido FJ+, Allergy 51, 758<br />

(1989): van Ketel WG+, Contact Dermatitis 20, 303<br />

(1988): Robinson PM, JLaryngolOtol102, 577<br />

Eczema<br />

(1988): Ghadially R+, JAmAcadDermatol19, 428<br />

Edema (1–10%)<br />

Erythema (1–10%)<br />

Exanthems (

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