Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

244 GADODIAMIDE
GADODIAMIDE
Trade name: Omniscan (Mallinckrodt)
Indications: Magnetic resonance imaging (MRI)
Category: Diagnostic aid; Magnetic resonance imaging contrast
medium
Half-life: N/A
Clinically important, potentially hazardous interactions
with: N/A
Note: Nephrogenic systemic fibrosis has been reported in patients
with end-stage renal failure who were treated with gadodiamide.
However, this serious side effect has not been reported in patients
with normal renal function
Reactions
Skin
Allergic reactions (sic)
(1999): Murphy KP+, Acad Radiol 6(11), 656
Diaphoresis
Exanthems
Facial edema
Pigmentation
Pruritus
(1996): Ekholm S+, Acta Radiol 37(2), 223
Purpura
Rash (sic)
Urticaria
(1996): Ekholm S+, Acta Radiol 37(2), 223
Mucosal
Sialorrhea
Xerostomia
Eyes
Visual disturbances
Other
Abdominal pain
Anaphylactoid reactions/Anaphylaxis
Cough
Fever
Hot flashes
Injection-site reactions
(1996): Aslanian V+, Neuroradiology 38(6), 537
(1996): Hogstrom B+, JMagnReson6(1), 255
(1995): Aslanian V+, J Radiol 76(7), 431
Myalgia/Myositis/Myopathy/Myotoxicity
Nephrotoxicity
(2007): Broome DR+, AJR Am J Roentgenol 188(2), 586
(2007): High WA+, JAmAcadDermatol56(4), 710
(2007): Karlik SJ, AJR Am J Roentgenol 188(6), W584
(2007): Khurana A+, Invest Radiol 42(2), 139
(2006): Briguori C+, Catheter Cardiovasc Interv 67(2), 175
(2006): Grobner T, NephrolDialTransplant21(4), 1104
(2006): Marckmann P+, JAmSocNephrol17(9), 2359
(2006): Thomsen HS, Eur Radiol 16(12), 2619
(2006): Thomsen HS+, Clin Radiol 61(11), 905
(2004): Thomsen HS, Eur Radiol 14(9), 1654
Pain
Thrombophlebitis
GALANTAMINE
Trade name: Reminyl (Janssen)
Indications: Alzheimer’s disease
Category: Cholinesterase inhibitor
Half-life: 6–8 hours
Clinically important, potentially hazardous interactions
with: bethanechol, cimetidine, donepezil, edrophonium,
physostigmine, pilocarpine, rivastigmine, succinylcholine, tacrine
Note: Derived from snowdrop (Galanthus sp) bulbs
Reactions
Skin
Acute generalized exanthematous pustulosis (AGEP)
(2002): Gantcheva M+, World Congress Dermatol Poster, 1588
Edema
Peripheral edema (>2%)
Purpura (>2%)
Mucosal
Sialorrhea
Xerostomia
Other
Death
(2006): Prescrire Int 15(83), 103
Upper respiratory infection (>2%)
GALSULFASE
Trade name: Naglazyme (BioMarin)
Indications: Mucopolysaccharidosis
Category: Enzyme
Half-life: 9–26 hours
Clinically important, potentially hazardous interactions
with: N/A
Reactions
Skin
Angioedema
Facial edema (11%)
Rash (sic)
Urticaria
Eyes
Conjunctivitis
Corneal opacity (11%)
Other
Abdominal pain (53%)
Application-site reactions (>50%)
Chills
Cough
Fever
Pain (26%)