Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Thrombophlebitis
*Note: Furosemide is a sulfonamide and can be absorbed
systemically. Sulfonamides can produce severe, possibly fatal,
reactions such as toxic epidermal necrolysis and Stevens–Johnson
syndrome
**Note: Grinspan’s syndrome is the triad of oral lichen planus,
diabetes mellitus, and hypertension
FUSIDIC ACID
Trade names: Fucidin (Leo); Fucithalmic (Leo)
Indications: Angular cheilitis, Bacterial infections, Ocular
infections
Category: Antibacterial
Half-life: N/A
Clinically important, potentially hazardous interactions
with: atorvastatin, simvastatin
Reactions
Skin
Acanthosis nigricans
(1993): Teknetzis A+, JAmAcadDermatol28(3), 501
Dermatitis
(2000): Lee AY+, Contact Dermatitis 42(1), 53
(1999): Christiansen K, Int J Antimicrob Agents 12 Suppl 2, S3
(1996): Giordano-Labadie F+, Contact Dermatitis 34(2), 159
(1990): Baptista A+, Contact Dermatitis 23(3), 186
(1988): Hogan DJ, CMAJ 138(4), 336 (widespread)
(1985): Romaguera C+, Contact Dermatitis 12(3), 176
(1982): de Groot AC+, Contact Dermatitis 8(6), 429
Jaundice
(1993): Haddad M+, Eur J Clin Microbiol Infect Dis 12(9), 725
(1983): McAreavey D+, Scott Med J 28(2), 179
(1980): Humble MW+, Br Med J 280(6230), 1495 (34%)
Rash (sic)
(1990): Stonelake PS, BMJ 301(6763), 1281
(1989): Youle MS+, J Acquir Immune Defic Syndr 2(1), 59
Eyes
Ocular burning
(1996): Malminiemi K+, Acta Ophthalmol Scand 74(3), 280
Ocular edema
(1996): Adenis JP+, Eur J Ophthalmol 6(4), 368
Other
Abdominal pain
(1989): Youle MS+, J Acquir Immune Defic Syndr 2(1), 59
Hepatotoxicity
(1999): Christiansen K, Int J Antimicrob Agents 12 Suppl 2, S3
Hypersensitivity
(1990): Riess CE+, Lancet 335(8704), 1525
Nephrotoxicity
(1997): Davies JP+, Int J Clin Pract 51(4), 264
(1993): Phillips AO+, NephrolDialTransplant8(6), 572
Rhabdomyolysis
(2003): Yuen SL+, Med J Aust 179(3), 172 (with simvastatin)
(2000): Wenisch C+, Am J Med 109(1), 78 (with atorvastatin)
Thrombophlebitis
(1981): Iwarson S+, Scand J Infect Dis 13(1), 65
GABAPENTIN
Trade name: Neurontin (Pfizer)
Indications: Seizures
Category: Anticonvulsant
Half-life: 5–6 hours
Reactions
GABAPENTIN 243
Skin
Acne (>1%)
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)
(2001): Popescu C, Bucharest, Romania (from Internet)
(observation)
(1999): Smith W (from Internet) (observation)
Bullous pemphigoid
(2002): Zachariae CO, Acta Derm Venereol 82(5), 396
Edema
(2006): Kanbay M+, Clin Neuropharmacol 29(3), 186
(2003): Huber B+, Seizure 12(8), 602 (2 cases)
(2002): Prescrire Int 11(60), 111
(2002): Gueguen A+, Presse Med 31(33), 1559
Exanthems
(2003): Warnock JK+, Am J Clin Dermatol 4(1), 21
(1999): DeToledo JC+, Ther Drug Monit 21(1), 137
Facial edema (