Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Reactions Skin Angioedema Erythema Pruritus Rash (sic) (1.1%) Urticaria Mucosal Xerostomia (1%) (1990): Schultze-Werninghaus G, Lung 168 (Suppl 83–9) (1%) Other Anaphylactoid reactions/Anaphylaxis (1%) Cough (1990): Schultze-Werninghaus G, Lung 168 (Suppl 83-9) Death (2006): Aaronson DW, J Allergy Clin Immunol 117(1), 40 Infections (3%) Myalgia/Myositis/Myopathy/Myotoxicity FOSAMPRENAVIR* Trade name: Lexiva (GSK) Indications: HIV infections (in combination with other antiretrovirals) Category: Antiretroviral; Protease inhibitor, HIV Half-life: 7.7 hours Clinically important, potentially hazardous interactions with: amiodarone, atorvastatin, bepridil, carbamazepine, delavirdine, dihydroergotamine, flecainide, itraconazole, ketoconazole, lidocaine, lovastatin, midazolam, phenobarbital, phenytoin, pimozide, propafenone, quinidine, rifabutin, rifampin, sildenafil, simvastatin, St John’s wort, triazolam, vardenafil, warfarin Reactions Skin Exanthems Pruritus (7%) Rash (sic) (~19%) (2004): Chapman TM+, Drugs 64(18), 2101 Stevens–Johnson syndrome Other Abdominal pain (5%) (2004): Chapman TM+, Drugs 64(18), 2101 Hypersensitivity (2006): Gathe JC Jr+, Clin Ther 28(5), 745 (7%) (with ritonavir) (2004): Chapman TM+, Drugs 64(18), 2101 Infections *Note: Fosamprenavir is a prodrug of amprenavir **Note: Fosamprenavir is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens–Johnson syndrome FOSCARNET Trade names: Foscavir (AstraZeneca); Foscovir Indications: Cytomegalovirus retinitis in patients with AIDS Category: Antiviral; DNA & RNA polymerase inhibitor Half-life: ~3 hours Clinically important, potentially hazardous interactions with: adefovir, cyclosporine Reactions FOSCARNET 239 Skin Acne Dermatitis (5%) Edema (5%) (2001): Roos TC+, JAmAcadDermatol44, 546 (1990): Green ST, JInfection21, 227 Facial edema (>5%) Fixed eruption (1990): Connolly GM+, Genitourin Med 66, 97 Herpes simplex (5%) (2001): Roos TC+, JAmAcadDermatol44, 546 Pruritus ani et vulvae (5%) Toxic epidermal necrolysis (1999): Wharton JR+, Cutis 63, 333 (1997): Lauglin CL, Little Rock, Arkansas, American Academy of Dermatology Meeting, (SF) (gross and microscopic) Ulcerations (>5%) Urticaria (
240 FOSCARNET Oral ulceration (2000): Madinier I+, Ann Med Interne (Paris) (French) 151, 248 (1997): Schiodt M, Oral Dis 3 Suppl 1, S208 (1990): Fégueux S+, Lancet 335, 547 (1990): Gilquin J+, Lancet 335, 287 (1990): Moyle G+, Lancet 335, 547 Stomatitis (
- Page 264 and 265: DOMPERIDONE Trade names: Evoxin; Mo
- Page 266 and 267: DOXAPRAM Trade name: Dopram (Baxter
- Page 268 and 269: (1989): Jones AP+, Br J Cancer 59,
- Page 270 and 271: (1992): Bennett MJ, JRArmyMedCorps1
- Page 272 and 273: ECHINACEA Scientific names: Echinac
- Page 274 and 275: Hot flashes (
- Page 276 and 277: Pemphigus vegetans (1994): Bastiaen
- Page 278 and 279: Stevens-Johnson syndrome (
- Page 280 and 281: Ocular pruritus (1-10%) Other Cough
- Page 282 and 283: (2002): Bohm M+, Drug Saf 25(8), 59
- Page 284 and 285: Pustules (1993): Manu Shah R+, Eur
- Page 286 and 287: ESTAZOLAM Trade names: Domnamid; Es
- Page 288 and 289: Allergic reactions (sic) Cellulitis
- Page 290 and 291: Exanthems Photosensitivity Purpura
- Page 292 and 293: Other Anticonvulsant hypersensitivi
- Page 294 and 295: ETORICOXIB Trade names: Algix; Arco
- Page 296 and 297: Purpura (1996): Kallal SM+, West J
- Page 298 and 299: (1980): Couzigou P+, Therapie 35(3)
- Page 300 and 301: FINASTERIDE Trade names: Pro-Cure;
- Page 302 and 303: (1991): Abbott M+, Lancet 2, 633 Bu
- Page 304 and 305: FLUOCINOLONE Trade names: Capex (Ga
- Page 306 and 307: (2003): Salim A+, Br J Dermatol 148
- Page 308 and 309: Erythema multiforme (1985): Wernick
- Page 310 and 311: Injection-site reactions Rhabdomyol
- Page 312 and 313: Toxic epidermal necrolysis Urticari
- Page 316 and 317: Reactions Skin Acne (
- Page 318 and 319: Thrombophlebitis *Note: Furosemide
- Page 320 and 321: GANCICLOVIR Trade names: Cymevan; C
- Page 322 and 323: (2002): Baselga J+, J Clin Oncol 20
- Page 324 and 325: (2003): D’Alessandro V+, Clin Ter
- Page 326 and 327: (1996): Merlob P+, Cutis 57, 429 (n
- Page 328 and 329: Hair Hair - alopecia (>2%) Nails Na
- Page 330 and 331: GLYBURIDE Synonyms: glibenclamide;
- Page 332 and 333: (1982): Bailin PL+, Clin Rheum Dis
- Page 334 and 335: Acne (1996): Lee PK+, JAmAcadDermat
- Page 336 and 337: (2006): Bonkovsky HL, AnnInternMed1
- Page 338 and 339: Peripheral edema (>10%) Purpura Urt
- Page 340 and 341: (1984): Binder RL+, J Clin Psychiat
- Page 342 and 343: HEPARIN Trade names: Calcilean; Cal
- Page 344 and 345: (1990): Rogerson SJ+, BMJ 301, 345
- Page 346 and 347: (1991): Vitris M+, Dakar Med 36(1),
- Page 348 and 349: Other Anaphylactoid reactions/Anaph
- Page 350 and 351: Exanthems Exfoliative dermatitis Fi
- Page 352 and 353: HYDROMORPHONE Trade names: Dilaudid
- Page 354 and 355: (1994): Perrot JL+, Ann Dermatol Ve
- Page 356 and 357: Edema (
- Page 358 and 359: (1994): Halpern SM, Arch Dermatol 1
- Page 360 and 361: Mucosal Oral lesions Sialorrhea (
- Page 362 and 363: IMIGLUCERASE Trade name: Cerezyme (
Reactions<br />
Skin<br />
Angioedema<br />
Erythema<br />
Pruritus<br />
Rash (sic) (1.1%)<br />
Urticaria<br />
Mucosal<br />
Xerostomia (1%)<br />
(1990): Schultze-Werninghaus G, Lung 168 (Suppl 83–9) (1%)<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis (1%)<br />
Cough<br />
(1990): Schultze-Werninghaus G, Lung 168 (Suppl 83-9)<br />
Death<br />
(2006): Aaronson DW, J Allergy Clin Immunol 117(1), 40<br />
Infections (3%)<br />
Myalgia/Myositis/Myopathy/Myotoxicity<br />
FOSAMPRENAVIR*<br />
Trade name: Lexiva (GSK)<br />
Indications: HIV infections (in combination with other<br />
antiretrovirals)<br />
Category: Antiretroviral; Protease inhibitor, HIV<br />
Half-life: 7.7 hours<br />
Clinically important, potentially hazardous interactions<br />
with: amiodarone, atorvastatin, bepridil, carbamazepine,<br />
delavirdine, dihydroergotamine, flecainide, itraconazole,<br />
ketoconazole, lidocaine, lovastatin, midazolam, phenobarbital,<br />
phenytoin, pimozide, propafenone, quinidine, rifabutin, rifampin,<br />
sildenafil, simvastatin, St John’s wort, triazolam, vardenafil,<br />
warfarin<br />
Reactions<br />
Skin<br />
Exanthems<br />
Pruritus (7%)<br />
Rash (sic) (~19%)<br />
(2004): Chapman TM+, <strong>Drug</strong>s 64(18), 2101<br />
Stevens–Johnson syndrome<br />
Other<br />
Abdominal pain (5%)<br />
(2004): Chapman TM+, <strong>Drug</strong>s 64(18), 2101<br />
Hypersensitivity<br />
(2006): Gathe JC Jr+, Clin Ther 28(5), 745 (7%) (with ritonavir)<br />
(2004): Chapman TM+, <strong>Drug</strong>s 64(18), 2101<br />
Infections<br />
*Note: Fosamprenavir is a prodrug of amprenavir<br />
**Note: Fosamprenavir is a sulfonamide <strong>and</strong> can be absorbed<br />
systemically. Sulfonamides can produce severe, possibly fatal,<br />
reactions such as toxic epidermal necrolysis <strong>and</strong> Stevens–Johnson<br />
syndrome<br />
FOSCARNET<br />
Trade names: Foscavir (AstraZeneca); Foscovir<br />
Indications: Cytomegalovirus retinitis in patients with AIDS<br />
Category: Antiviral; DNA & RNA polymerase inhibitor<br />
Half-life: ~3 hours<br />
Clinically important, potentially hazardous interactions<br />
with: adefovir, cyclosporine<br />
Reactions<br />
FOSCARNET 239<br />
Skin<br />
Acne<br />
Dermatitis (5%)<br />
Edema (5%)<br />
(2001): Roos TC+, JAmAcadDermatol44, 546<br />
(1990): Green ST, JInfection21, 227<br />
Facial edema (>5%)<br />
Fixed eruption<br />
(1990): Connolly GM+, Genitourin Med 66, 97<br />
Herpes simplex (5%)<br />
(2001): Roos TC+, JAmAcadDermatol44, 546<br />
Pruritus ani et vulvae (5%)<br />
Toxic epidermal necrolysis<br />
(1999): Wharton JR+, Cutis 63, 333<br />
(1997): Lauglin CL, Little Rock, Arkansas, American Academy of<br />
Dermatology Meeting, (SF) (gross <strong>and</strong> microscopic)<br />
Ulcerations (>5%)<br />
Urticaria (
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