Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Injection-site reactions Rhabdomyolysis FLURAZEPAM Trade names: Apo-Flurazepam; Benozil; Dalmadorm; Dalmane (Valeant); Flunox; Flurazepam (Watson); Nergart; Novoflupam; Som Pam; Somnol; Valdorm Indications: Insomnia Category: Benzodiazepine Half-life: 40–114 hours Clinically important, potentially hazardous interactions with: amprenavir, chlorpheniramine, clarithromycin, efavirenz, esomeprazole, imatinib, indinavir, nelfinavir, ritonavir Reactions Skin Dermatitis (1–10%) Diaphoresis (>10%) Exanthems Pruritus Purpura Rash (sic) (>10%) Toxic epidermal necrolysis (2005): Loncar C+, Psychiatr Danub 17(3-4), 236 Urticaria Mucosal Oral lesions (1984): Greenblatt DJ+, J Clin Psychiatry 45, 192 (3%) Sialopenia (>10%) Sialorrhea (1–10%) Xerostomia (>10%) FLURBIPROFEN Trade names: Ansaid (Pfizer); Apo-Flurbiprofen; Cebutid; Flurofen; Flurozin; Froben; Lapole; Nu-Flurprofen Indications: Arthritis Category: Non-steroidal anti-inflammatory Half-life: 3–4 hours Clinically important, potentially hazardous interactions with: methotrexate Reactions Skin Angioedema (

236 FLUTAMIDE (1999): Fisher BJ, Toronto, Ontario (generalized) (from Internet) (observation) (1989): Brogden RN+, Drugs 38, 185 Lupus erythematosus (1998): Reid MB+, JUrol159, 2098 Photosensitivity (2003): Kaur C+, Br J Dermatol 148(3), 603 (1999): Tsien C+, JUrol162, 494 (1998): Vilaplana J+, Contact Dermatitis 38, 68 (1998): Yokote R+, Eur J Dermatol 8, 427 (1996): Fujimoto M+, Br J Dermatol 135, 496 (1996): Leroy D+, Photodermatol Photoimmunol Photomed 12(5), 216 (1991): Moraillon I+, Photodermatol Photoimmunol Photomed 8, 264 Rash (sic) (3%) Toxic epidermal necrolysis Urticaria Other Gynecomastia (9%) (1997): Staiman VR+, Urology 50, 929 (1993): Aso Y+, Hinyokika Kiyo (Japanese) 39, 391 Hepatotoxicity (2005): Papaioannides D+, Int Urol Nephrol 37(3), 515 Hot flashes (61%) Injection-site irritation (3%) Pseudoporphyria (1999): Mantoux F+, Ann Dermatol Venereol (French) 126, 150 (1999): Schmutz JL+, Ann Dermatol Venereol (French) 126, 374 (1998): Borroni G+, Br J Dermatol 138, 711 FLUTICASONE Trade names: Cutivate (GSK); Flonase (GSK); Flovent (GSK) Indications: Dermatoses, rhinitis Category: Corticosteroid, inhaled; Corticosteroid, topical Half-life: N/A Clinically important, potentially hazardous interactions with: ketoconazole, live vaccines, oral contraceptives, ritonavir Reactions Skin Acne Atrophy (1996): Johnson M, Cutis 57(2), 10 Bruising (2005): Man SF+, Drugs 65(5), 579 Burning (1996): Johnson M, Cutis 57(2), 10 (1996): Lebwohl M, Cutis 57(2), 62 Edema Pruritus (1996): Johnson M, Cutis 57(2), 10 (1996): Lebwohl M, Cutis 57(2), 62 Rash (sic) Vasculitis (2003): English J 3rd+, J Drugs Dermatol 2(3), 326 (2002): Koya T+, Arerugi 51(11), 1127 (2001): Termeer C+, Arch Dermatol 137(11), 1527 Mucosal Oral candidiasis (2005): Adams NP+, Cochrane Database Syst Rev (4), CD003135 (2005): Lipworth BJ+, Ann Allergy Asthma 94(4), 465 (22%) (2005): Man SF+, Drugs 65(5), 579 (2004): Donohue JF+, Treat Respir Med 3(3), 173 (2003): Fukushima C+, Ann Allergy Asthma Immunol 90(6), 646 (2003): Hanania NA+, Chest 124(3), 834 (2003): Powell H+, Med J Aust 178(5), 223 (2003): Randell TL+, Paediatr Drugs 5(7), 481 (rare) (2002): Lyseng-Williamson KA+, Am J Respir Med 1(4), 273 (1999): Spencer CM+, Drugs 57(6), 933 Eyes Cataract (2004): Bisgaard H+, Pediatrics 113(2), e87 Ocular pressure (2004): Sihota R+, Indian J Ophthalmol 52(2), 170 Other Adverse effects (sic) (2003): Coghlan D+, Paediatr Drugs 5(10), 685 (rare) (2000): Kokot M, Pol Merkuriusz Lek 8(47), 330 (%) (1999): Todd GR, EurRespirJ13(3), 707 (1996): Lebwohl M, Cutis 57(2), 62 Chills Cough (2004): Bisgaard H+, Pediatrics 113(2), e87 (2003): Dubus JC+, Fundam Clin Pharmacol 17(5), 627 Death (2006): Li AM, JPediatr148(3), 294 (with ritonavir) Fever Infections (2002): Bratton RL+, Mayo Clin Proc 77(12), 1353 (2002): Peter E+, Clin Infect Dis 35(5), e54 (2000): Leav BA+, NEnglJMed343(8), 586 (1999): Fairfax AJ+, Thorax 54(9), 860 Myalgia/Myositis/Myopathy/Myotoxicity (2004): De Swert+, NEnglJMed350(11), 1157 FLUVASTATIN Trade names: Cranoc; Lescol (Novartis); Locol Indications: Hypercholesterolemia Category: HMG-CoA reductase inhibitor; Statin Half-life: 1.2 hours Clinically important, potentially hazardous interactions with: azithromycin, bosentan, ciprofibrate, clarithromycin, cyclosporine, erythromycin, gemfibrozil, imatinib, red rice yeast Reactions Skin Allergic reactions (sic) (2.6%) Angioedema Dermatomyositis (2005): Thual N+, Ann Dermatol Venereol 132(12), 996 Erythema multiforme Lichenoid eruption (2004): Sebok B+, Acta Derm Venereol 84(3), 229 Lupus erythematosus (1998): Sridhar MK+, Lancet 352, 114 (fatal) Photosensitivity Pigmentation Pruritus Purpura Rash (sic) (2.7%) (1998): N Z Medicines Adverse Reactions Committee (2 patients) (from Internet) (observation) Stevens–Johnson syndrome

Injection-site reactions<br />

Rhabdomyolysis<br />

FLURAZEPAM<br />

Trade names: Apo-Flurazepam; Benozil; Dalmadorm; Dalmane<br />

(Valeant); Flunox; Flurazepam (Watson); Nergart; Novoflupam;<br />

Som Pam; Somnol; Valdorm<br />

Indications: Insomnia<br />

Category: Benzodiazepine<br />

Half-life: 40–114 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amprenavir, chlorpheniramine, clarithromycin, efavirenz,<br />

esomeprazole, imatinib, indinavir, nelfinavir, ritonavir<br />

Reactions<br />

Skin<br />

Dermatitis (1–10%)<br />

Diaphoresis (>10%)<br />

Exanthems<br />

Pruritus<br />

Purpura<br />

Rash (sic) (>10%)<br />

Toxic epidermal necrolysis<br />

(2005): Loncar C+, Psychiatr Danub 17(3-4), 236<br />

Urticaria<br />

Mucosal<br />

Oral lesions<br />

(1984): Greenblatt DJ+, J Clin Psychiatry 45, 192 (3%)<br />

Sialopenia (>10%)<br />

Sialorrhea (1–10%)<br />

Xerostomia (>10%)<br />

FLURBIPROFEN<br />

Trade names: Ansaid (Pfizer); Apo-Flurbiprofen; Cebutid;<br />

Flurofen; Flurozin; Froben; Lapole; Nu-Flurprofen<br />

Indications: Arthritis<br />

Category: Non-steroidal anti-inflammatory<br />

Half-life: 3–4 hours<br />

Clinically important, potentially hazardous interactions<br />

with: methotrexate<br />

Reactions<br />

Skin<br />

Angioedema (

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