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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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228 FLUDARABINE<br />

(2007): Satzger I+, Eur J Dermatol 17(2), 165<br />

Paraneoplastic pemphigus<br />

(2004): Powell AM+, J Eur Acad Dermatol Venereol 18(3), 360<br />

(2001): Gooptu C+, Br J Dermatol 144(6), 1255 (3 cases)<br />

(1995): Bazarbachi A+, Ann Oncol 6, 730<br />

Petechiae<br />

(2001): Churn M+, Clin Oncol 13, 273<br />

Rash (sic) (>10%)<br />

(2003): Leitman SF+, Transfusion 43(12), 1667<br />

Squamous cell carcinoma<br />

(1997): Davidovitz Y+, Acta Haematol 98, 44 (flare-up)<br />

Mucosal<br />

Stomatitis (>10%)<br />

Hair<br />

Hair – alopecia (1–10%)<br />

Other<br />

Application-site reactions<br />

(2002): Rai KR+, J Clin Oncol 20(18), 3891 (with alemtuzumab)<br />

Chills (>10%)<br />

Death<br />

(2002): Klasa RJ+, J Clin Oncol 20(24), 4649 (3 patients)<br />

Fever<br />

(2003): Leitman SF+, Transfusion 43(12), 1667<br />

Infections<br />

(2002): Rai KR+, J Clin Oncol 20(18), 3891 (with alemtuzumab)<br />

Myalgia/Myositis/Myopathy/Myotoxicity (>10%)<br />

FLUMAZENIL<br />

Trade names: Anexate; Lanexat; Romazicon (Roche)<br />

Indications: Benzodiazepine overdose<br />

Category: Benzodiazepine antagonist<br />

Half-life: terminal: 41–79 minutes<br />

Clinically important, potentially hazardous interactions<br />

with: alcohol, neuromuscular blockers<br />

Reactions<br />

Skin<br />

Diaphoresis (3–9%)<br />

Rash (sic)<br />

Urticaria (

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