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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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226 FLECAINIDE<br />

FLECAINIDE<br />

Trade names: Almarytm; Apocard; Corflene; Flecaine; Tabco;<br />

Tambocor (3M)<br />

Indications: Atrial fibrillation<br />

Category: Antiarrhythmic class 1c<br />

Half-life: 7–22 hours<br />

Clinically important, potentially hazardous interactions<br />

with: darifenacin, fosamprenavir, ritonavir, tipranavir<br />

Reactions<br />

Skin<br />

Diaphoresis (1%)<br />

(2003): Litt JZ, Beachwood, OH (personal case) (observation)<br />

(1985): Holmes B+, <strong>Drug</strong>s 27, 301 (1.4%)<br />

Exfoliative dermatitis (

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