Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

FINASTERIDE
Trade names: Pro-Cure; Propecia (Merck); Proscar (Merck);
Proscar 5
Indications: Benign prostatic hypertrophy, male-pattern
baldness
Category: 5-alpha reductase inhibitor; Androgen antagonist
Half-life: 4.8–6 hours
Reactions
Skin
Edema of lip
Erythema annulare centrifugum
(2007): Al Hammadi A+, J Drugs Dermatol 6(4), 460
Folliculitis
(2000): Price VH+, JAmAcadDermatol43, 768
Rash (sic)
(1999): Cather JC+, Cutis 64, 167
Urticaria
Hair
Hair – hypotrichosis
(1998): Panagotacos PJ (reversal of graying hair) (from Internet)
(observation)
Hair – patchy hair, loss of beard
(1999): Mitchell D, Thomasville, GA (from Internet)
(observation)
(1998): Drayton GE, Los Angeles, CA (from Internet)
(observation)
Nails
Nails – onychomycosis
(1999): Mitchell D, Thomasville, GA (from Internet)
(observation)
Other
Gynecomastia
(2002): Ferrando J+, Arch Dermatol 138, 543
(2000): Wade MS+, Australas J Dermatol 41, 55 (painful and
reversible)
(2000): Zimmerman RL+, Arch Pathol Lab Med 124, 625
(1999): Cather JC+, Cutis 64, 167 (passim)
(1999): Miller JA+, South Med J 92, 615
(1997): Carlin BI+, JUrol158, 547
(1997): Staiman VR+, Urology 50, 929
(1996): Green L+, New Engl J Med 335, 823
(1996): Wilton L+, Br J Urol 78, 379
(1995): Volpi R+, Am J Med Sci 309, 322
Hepatotoxicity
(2006): Martinez de Guzman M+, Farm Hosp 30(6), 385
Myalgia/Myositis/Myopathy/Myotoxicity (severe)
(1999): Cather JC+, Cutis 64, 167
FISH OILS
Scientific names: docosahexaenoic acid (DHA); eicosapentaenoic
acid (EPA); Omega-3 fatty acids
Trade and other common names: Cod liver oil; n-3 fatty
acids; polyunsaturated fatty acids (PUFA)
Category: Anti-inflammatory; Lipid regulator
Purported indications and other uses: Albuminuria, anorexia
nervosa, cardiovascular disease, hypertension, lupus
erythematosus, macular degeneration, osteoarthritis, otitis media,
psoriasis
Half-life: N/A
Note: More than 25 mL or 3 g per day can decrease blood
coagulation and increase the risk of bleeding. Fish oils contain a
significant amount of vitamins A and D and high doses may be toxic
Reactions
Skin
Malignant melanoma
(1997): Veierod MB+, Int J Cancer 71(4), 600
Eyes
Glaucoma
(2004): Kang JH+, Am J Clin Nutr 79(5), 755
Other
Lymphoid hyperplasia
(1988): Ogden P+, AnnInternMed109(10), 843
FLAVOXATE
Trade names: Bladderon; Genurin; Harnin; Patricin; Spasuret;
Urispadol; Urispas (Ortho-McNeil); Uronid
Indications: Dysuria, urgency, nocturia
Category: Anticholinergic; Muscarinic antagonist
Half-life: Onset of action: 55–60 minutes
Clinically important, potentially hazardous interactions
with: anticholinergics, arbutamine
Reactions
Skin
Exanthems
Fixed eruption
(1999): Enomoto U+, Contact Dermatitis 40(6), 337
Jaundice
(1999): Sevenoaks M+, JRSocMed92(11), 589
Rash (sic) (10%)
Other
Hypersensitivity
(1986): Hirohata S+, Arch Intern Med 146, 2409
FLAVOXATE 225