Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

ETORICOXIB
Trade names: Algix; Arcoxia (Merck); Tauxib
Indications: Rheumatoid arthritis, osteoarthritis, ankylosing
spondylitis, chronic low back pain, dysmenorrhea, acute gouty
arthritis
Category: COX-2 inhibitor; Non-steroidal anti-inflammatory
Half-life: 22 hours
Clinically important, potentially hazardous interactions
with: ACE inhibitors, cyclosporin, lithium, methotrexate,
rifampicin, tacrolimus, warfarin, and other oral anticoagulants
Reactions
Skin
Angioedema
(2005): Sanchez-Borges M+, Ann Allergy Asthma Immunol
95(2), 154
Erythema
(2006): Augustine M+, Indian J Dermatol Venereol Leprol
72(4), 307 (generalized)
Exanthems
(2006): Atzori L+, J Cutan Med Surg 10(1), 31
Fixed eruption
(2006): Augustine M+, Indian J Dermatol Venereol Leprol
72(4), 307
Stevens–Johnson syndrome
(2006): Layton D+, Drug Saf 29(8), 687
Urticaria
(2007): Muratore L+, Ann Allergy Asthma Immunol 98(2), 168
(2005): Nettis E+, Ann Allergy Asthma Immunol 95(5), 438
(2005): Sanchez-Borges M+, Ann Allergy Asthma Immunol
95(2), 154
Other
Abdominal pain
Upper respiratory infection
(2006): Tsoukas C+, Blood 107(5), 1785
EUCALYPTUS
Scientific names: Eucalyptus bicostata; Eucalyptus fruticetorum;
Eucalyptus globulus; Eucalyptus odorata; Eucalyptus pauciflora;
Eucalyptus polybractea; Eucalyptus smithii
Family: Myrtacceae
Trade and other common names: Blue gum; Blue mallee oil;
Dristan Nasal Decongestant Spray; Fever tree; Gully gum oil;
Listerine; Red gum; Stringy bark; Vicks VapoRub. Mentho-Lyptus
(Hall) in mouthwash; toothpaste, cough drops, lozenges
Category: Anti-inflammatory; Diuretic
Purported indications and other uses: Asthma, bronchitis,
cough, croup, fever, joint and muscle pains, nasal congestion, sore
throats, rheumatism.
Flavoring, fragrance, toothpaste, substances used in root canal
fillings
Half-life: N/A
Clinically important, potentially hazardous interactions
with: amitriptyline, borage, carisoprodol, coltsfoot, comfrey,
diazepam, haloperidol, insulin, lansoprazole, nelfinavir,
omeprazole, ondansetron, pantoprazole, propranolol,
theophylline, verapamil
Reactions
Skin
Cyanosis
Dermatitis
(1995): Schaller M+, Clin Exp Dermatol 20(2), 143
Rash
(2000): Ernst E, Br J Dermatol 143(5), 923
Eyes
Miosis
Other
Death [O]
Toxicity (sic)
Note: [O] is oral
EVENING PRIMROSE
Scientific names: Oenothera biennis; Oenothera muricata;
Oenothera purpurata; Oenothera rubricaulis; Oenothera suaveolens
Family: Onagraceae
Trade and other common names: EPO; Fever Plant; Gamma
Linolenic Acid; GLA; Night Willow-Herb; Scabish; Sun Drop
Category: Anti-inflammatory; Gamma linoleic acid
Purported indications and other uses: Mastalgia,
osteoporosis, atopic dermatitis, rheumatoid arthritis,
hypercholesterolemia, chronic fatigue syndrome,
neurodermatitis, ulcerative colitis, irritable bowel syndrome.
Used in soaps and cosmetics
Half-life: N/A
Clinically important, potentially hazardous interactions
with: aspirin, chlorpromazine, fluphenazine, phenothiazine,
thioridazine, warfarin
Skin
Adverse effects (sic)
EVENING PRIMROSE 219
Reactions