Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

218 ETODOLAC
(2000): Mitchell D, Thomasville, GA (from Internet)
(observation)
(1996): Thaler D, Monona, WI (pressure) (personal case)
(observation)
Vasculitis
(1996): Lie JT+, J Rheumatol 23, 183 (hypersensitivity)
(1989): Willemin B+, Ann Méd Int (French) 140, 529
Vesiculobullous eruption
Mucosal
Gingival ulceration
Glossitis
Sialorrhea
Stomatitis
Ulcerative stomatitis
Xerostomia
Hair
Hair – alopecia
Other
Gynecomastia
ETOPOSIDE
Synonyms: epipodophyllotoxin; VP-16; VP-16–213
Trade names: Aside; Etopos; Etosid; Lastet; Serozide; VePesid
(Bristol-Myers Squibb); Vepeside; VP-TEC
Indications: Lymphomas, carcinomas
Category: Topoisomerase 2 inhibitor
Half-life: terminal: 4–15 hours
Clinically important, potentially hazardous interactions
with: aldesleukin, cyclosporine, prednisolone, St John’s wort
Reactions
Skin
Acral erythema
(1997): Whitlock JA+, Leukemia 11(2), 185 (4 cases) (with
cytarabine)
Allergic reactions (sic) (1–2%)
Diaphoresis
Eccrine squamous syringometaplasia
(1997): Valks R+, Arch Dermatol 133, 873
Erythema
(1994): Portal I+, Cancer Chemother Pharmacol 34, 181 (acral)
(1993): Dechaufour F+, Ann Dermatol Venereol (French)
120, 219 (acral)
(1993): Vukelja SJ+, Cutis 52, 89 (acral)
Erythema multiforme
(1987): Yokel BK+, JCutanPathol14, 326
Exanthems
(1992): Beyer J+, Bone Marrow Transplant 10, 491
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin
Blackwell, Oxford, 301 (passim)
(1987): Yokel BK+, JCutanPathol14, 326
(1981): Weiss RB+, AnnInternMed94, 66
Facial edema
Hand–foot syndrome
(2005): Marigny K+, Cancer Chemother Pharmacol 55(3), 244
(1997): Whitlock JA+, Leukemia 11(2), 185 (with cytarabine)
(1994): Portal I+, Cancer Chemother Pharmacol 34(2), 181
Neutrophilic eccrine hidradenitis
(1993): Nikkels AF+, Acta Clin Belg 48(6), 397
Photo-recall
(1993): Williams BJ+, Clin Exp Dermatol 18, 452 (ultraviolet)
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin
Blackwell, Oxford, 301 (passim)
(1987): Yokel BK+, JCutanPathol14, 326
Pigmentation
(2001): Mutafoglu-Uysal K+, Turk J Pediatr 43(2), 172
(1991): Singal R+, Pediatr Dermatol 8, 231
Pruritus
Purpura
Rash (sic)
Stevens–Johnson syndrome
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin
Blackwell, Oxford, 301 (passim)
(1987): Yokel BK+, JCutanPathol14, 326
(1983): Jameson CH+, Cancer Treat Rep 67, 1050
Urticaria
Mucosal
Mucositis (>10%)
Oral lesions (