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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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216 ETHCHLORVYNOL<br />

ETHCHLORVYNOL<br />

Trade names: Arvynol; Nostel<br />

Indications: Insomnia<br />

Category: Sedative<br />

Half-life: 10–20 hours<br />

Clinically important, potentially hazardous interactions<br />

with: antihistamines, brompheniramine, buclizine,<br />

chlorpheniramine, clemastine, dexchlorpheniramine, meclizine,<br />

tripelennamine<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

Bullous dermatitis (from overdose)<br />

(1990): Yell RP, Am J Emerg Med 8, 246<br />

(1980): Brodin MD+, JCutanPathol7, 326<br />

Diaphoresis<br />

Fixed eruption<br />

Pressure necrosis<br />

(1990): Chamberlain JM+, Am J Emerg Med 8, 467<br />

Pruritus<br />

Purpura<br />

Rash (sic) (1–10%)<br />

Urticaria<br />

Death<br />

Facial numbness<br />

Hypersensitivity<br />

ETHIONAMIDE<br />

Trade names: Ethatyl; Etiocidan; Myobid-250; Trecator-SC<br />

(Wyeth); Tubermin<br />

Indications: Tuberculosis<br />

Category: Antibiotic<br />

Half-life: 2–3 hours<br />

Reactions<br />

Skin<br />

Acne<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford (passim)<br />

Allergic reactions (sic) (1%)<br />

Butterfly eruption on the face<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford (passim)<br />

Eczema (chiefly involving the forehead)<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford, 159 (passim)<br />

Exanthems<br />

Ichthyosis<br />

Lupus erythematosus<br />

Peripheral edema<br />

(1987): Schmutz JL+, Ann Dermatol Venereol (French) 114, 569<br />

Photosensitivity<br />

Purpura<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford (passim)<br />

Rash (sic) (

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