Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

208 ERLOTINIB
(2007): Methvin AB+, Ophthal Plast Reconstr Surg 23(1), 63
(2006): Prescrire Int 15(83), 86 (12%)
Ectropion
(2007): Methvin AB+, Ophthal Plast Reconstr Surg 23(1), 63
Epiphora
(2007): Methvin AB+, Ophthal Plast Reconstr Surg 23(1), 63
Eyelashes – hypertrichosis
(2006): Roe E+, JAmAcadDermatol55(3), 429
Keratoconjunctivitis
Periorbital rash
(2007): Methvin AB+, Ophthal Plast Reconstr Surg 23(1), 63
Trichomegaly
(2007): Lane K+, Ophthal Plast Reconstr Surg 23(1), 65
(2006): Carser JE+, J Thorac Oncol 1(9), 1040
Other
Abdominal pain (11%)
Cough (33%)
Death
Hepatotoxicity
(2007): Ramanarayanan J+, JOP 8(1), 39
Infections (24%)
ERTAPENEM
Synonyms: L-749,345; MK-0826
Trade name: Invanz (Merck)
Indications: Severe resistant bacterial infections caused by
susceptible organisms
Category: Antibiotic, beta-lactam
Half-life: 4 hours
Clinically important, potentially hazardous interactions
with: probenecid
Reactions
Skin
Dermatitis (>1%)
Desquamation (>1%)
Diaphoresis (>1%)
Edema (3%)
Erythema (1–2%)
Facial edema (>1%)
Hematomas (1%)
Stomatitis (>1%)
Vaginal pruritus (>1%)
Vaginitis (1–3%)
Vulvovaginal candidiasis (>1%)
Other
Anaphylactoid reactions/Anaphylaxis (some fatal)
Candidiasis (>1%)
Chills (>1%)
Cough (1–2%)
Death (2.5%)
Hypersensitivity
Injection-site extravasation (0.7–2%)
Injection-site induration (>1%)
Injection-site pain (>1%)
(2002): Legua P+, Clin Ther 24(3), 434
Pain (>1%)
Phlebitis (1.5–2%)
Thrombophlebitis (1.5–2%)
ERYTHROMYCIN
Trade names: E-Mycin; E.E.S; Eramycin; Ery-Ped; Ery-Tab; Eryc
(Warner Chilcott); Erypar; Erythrocin; Eryzole; Ilosone; Ilotycin;
PCE (Abbott); Pediazole (Abbott); Robimycin; Wintrocin;
Wyamicin S
Indications: Various infections caused by susceptible organisms
Category: Antibiotic, macrolide
Half-life: 1.4–2 hours
Clinically important, potentially hazardous interactions
with: alfentanil, aminophylline, amoxicillin, ampicillin,
anticonvulsants, astemizole, atorvastatin, benzodiazepines,
bromocriptine, buprenorphine, bupropion, carbamazepine,
cilostazol, ciprofloxacin, cisapride, clindamycin, colchicine,
cyclosporine, dasatinib, digoxin, dihydroergotamine, diltiazem,
disopyramide, enoxacin, eplerenone, ergotamine, fluconazole,
fluoxetine, fluvastatin, gatifloxacin, HMG-CoA reductase
inhibitors, imatinib, itraconazole, ketoconazole, lomefloxacin,
lorazepam, lovastatin, methadone, methylprednisolone,
methysergide, midazolam, moxifloxacin, norfloxacin, ofloxacin,
paroxetine, pimozide, pravastatin, quinolones, repaglinide,
sertraline, sildenafil, simvastatin, sparfloxacin, tacrolimus,
tacrolimus, terfenadine, theophylline, triazolam, troleandomycin,
vardenafil, verapamil, vinblastine, warfarin, zaleplon, zolpidem
*Note: Eryzole and Pediazole are combinations of erythromycin and
sulfisoxazole
Reactions
Skin
Acne
Acute generalized exanthematous pustulosis (AGEP)
(1995): Moreau A+, Int J Dermatol 34, 263 (passim)
(1991): Roujeau J-C+, Arch Dermatol 127, 1333
Allergic reactions (sic) (