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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Ocular pruritus (1–10%)<br />

Other<br />

Cough (1–3%)<br />

Upper respiratory infection (~10%)<br />

(2004): Abelson MB+, Clin Ther 26(1), 35<br />

EPINEPHRINE<br />

Synonym: adrenaline<br />

Trade names: Adrenalin (Monarch); Adrenaline; Ana-Guard;<br />

AsthmaHaler; Bronitin; Bronkaid; Epi E-Z Pen; Epifrin; Epipen<br />

(DEY); Eppy; Eppystabil; Isopto-Epinal; MedihalerEpi; Primatene;<br />

Primatene Mist; S-2; Simplene<br />

Indications: Cardiac arrest, hay fever, asthma, anaphylaxis<br />

Category: Catecholamine; Sympathomimetic<br />

Half-life: N/A<br />

Duration of action: 1–4 hours<br />

Clinically important, potentially hazardous interactions<br />

with: albuterol, alpha-blockers, amitriptyline, amoxapine,<br />

atenolol, beta-blockers, carteolol, chlorpromazine, clomipramine,<br />

cocaine, desipramine, doxepin, ephedra, ergotamine,<br />

furazolidone, halothane, imipramine, insulin detemir, MAO<br />

inhibitors, metoprolol, nadolol, nortriptyline, penbutolol,<br />

phenelzine, phenoxybenzamine, phenylephrine, pindolol,<br />

prazosin, propranolol, protriptyline, sympathomimetics,<br />

terbutaline, thioridazine, timolol, tranylcypromine, tricyclic<br />

antidepressants, trimipramine, vasopressors<br />

Reactions<br />

Skin<br />

Dermatitis<br />

(1993): Gaspari AA, Contact Dermatitis 28, 35<br />

(1980): Romaguera C+, Contact Dermatitis 6, 364<br />

Diaphoresis (1–10%)<br />

Exanthems<br />

Fixed eruption<br />

Necrosis<br />

(1984): Antrum RM+, Br J Clin Pract 38, 191<br />

Pallor (

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