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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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DOMPERIDONE<br />

Trade names: Evoxin; Motilium (Johnson & Johnson)<br />

Indications: Investigational antiemetic, gastroesophageal reflux<br />

disease (GERD), nausea <strong>and</strong> vomiting<br />

Category: Dopamine receptor antagonist<br />

Half-life: 7–8 hours<br />

Clinically important, potentially hazardous interactions<br />

with: ketoconazole<br />

Note: Domperamol is domperidone & acetaminophen<br />

Reactions<br />

Skin<br />

Diaphoresis<br />

Edema<br />

Edema of lip<br />

Facial edema<br />

Facial erythema<br />

Lupus erythematosus<br />

(1986): Yasue T+, JDermatol13(4), 292<br />

Pruritus<br />

Rash (sic)<br />

(1981): Nagler J+, Am J Gastroenterol 76(6), 495<br />

Urticaria<br />

Mucosal<br />

Dry mucous membranes<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

Breast changes<br />

Death<br />

(1984): Giaccone G+, Lancet 2(8415):1336 (2 cases)<br />

(1982): Joss RA+, Lancet 1(8279):1019<br />

Gynecomastia<br />

(1991): Keating JP+, Postgrad Med J 67(786), 401<br />

(1982): van der Steen M+, Lancet 2(8303), 884 (in a male infant)<br />

Hypersensitivity<br />

Rhabdomyolysis<br />

(2002): Bourlon S+, Therapie 57(6), 597 (with rabeprazole)<br />

DONEPEZIL<br />

Synonym: E2020<br />

Trade name: Aricept (Eisai) (Endo)<br />

Indications: Mild dementia of the Alzheimer’s type<br />

Category: Cholinesterase inhibitor<br />

Half-life: 50–70 hours<br />

Clinically important, potentially hazardous interactions<br />

with: galantamine<br />

Skin<br />

Dermatitis (1%)<br />

Erythema (

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