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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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188 DOCETAXEL<br />

Injection-site extravasation<br />

(2000): Raley J+, Gynecol Oncol 78, 259<br />

(1995): Zimmerman GC+, Arch Dermatol 131, 202<br />

Injection-site pigmentation<br />

(2005): Aydogan I+, JEurAcadDermVen19, 345 (supravenous,<br />

serpentine)<br />

(2000): Schrijvers D+, Br J Dermatol 142, 1069<br />

(1995): Zimmerman GC+, Arch Dermatol 131, 202<br />

Injection-site reactions<br />

(2002): Eich D+, Am J Clin Oncol 25(6), 599 (passim)<br />

Myalgia/Myositis/Myopathy/Myotoxicity (>10%)<br />

(2006): Izquierdo MA+, Eur J Cancer 42(12), 1789 (with<br />

paclitaxel)<br />

(2005): Hughes BG+, Intern Med J 35(6), 369<br />

(2003): Qin YK+, Ai Zheng 22(4), 415<br />

Neurotoxicity<br />

(2006): Izquierdo MA+, Eur J Cancer 42(12), 1789 (with<br />

paclitaxel)<br />

(2006): Lee JJ+, J Clin Oncol 24(10), 1633<br />

(2005): Wampler MA+, Clin J Oncol Nurs 9(2), 189<br />

(2004): Furugen Y+, Gan To Kagaku Ryoho 31(8), 1205 (6%)<br />

(with carboplatin)<br />

(1998): Hainsworth JD+, J Clin Oncol 16(6), 2164<br />

Pain<br />

(2004): Gridelli C+, Br J Cancer 91(12), 1996<br />

(2002): Paciucci PA+, Anticancer <strong>Drug</strong>s 13(8), 791<br />

Thrombosis<br />

(2006): Laber DA+, Am J Clin Oncol 29(4), 389 (8%)<br />

DOCOSANOL<br />

Synonyms: Behenyl Alcohol; n-Docosanol<br />

Trade name: Abreva (GSK)<br />

Indications: Herpes simplex (labialis)<br />

Category: Antiviral, topical<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: None<br />

Skin<br />

Irritation (sic) (local)<br />

DOCUSATE<br />

Reactions<br />

Trade names: Colase (Purdue); Coloxyl; Dialose; Diocto;<br />

Disonate; DOK; Doxate-S; Doxinate; Hisof; Jamylene; Lambanol;<br />

Mollax; Peri-Colase (Purdue); Regulex; Regutol; Selax; SoFlax;<br />

Softon; Sulfalax; Surfak (Pfizer)<br />

Indications: Constipation<br />

Category: Stimulant laxative<br />

Half-life: N/A<br />

Onset of action: 12–72 hours<br />

Reactions<br />

Skin<br />

Dermatitis<br />

(1998): Lee AY+, Contact Dermatitis 38, 355<br />

Diaphoresis<br />

Exanthems (1%)<br />

Rash (sic)<br />

DOFETILIDE<br />

Trade name: Tikosyn (Pfizer)<br />

Indications: Conversion of atrial fibrillation <strong>and</strong> atrial flutter to<br />

normal sinus rhythm<br />

Category: Antiarrhythmic class III<br />

Half-life: 10 hours<br />

Clinically important, potentially hazardous interactions<br />

with: atazanavir, chlorpromazine, cimetidine, co-trimoxazole,<br />

fluphenazine, ketoconazole, medroxyprogesterone, megestrol,<br />

mesoridazine, phenothiazines, prochlorperazine, progestins,<br />

promethazine, thioridazine, trifluoperazine, trimethoprim,<br />

verapamil<br />

Skin<br />

Angioedema (2%)<br />

Edema<br />

Peripheral edema (>2%)<br />

Rash (sic) (3%)<br />

DOLASETRON<br />

Reactions<br />

Trade name: Anzemet (Sanofi-Aventis)<br />

Indications: Prevention of nausea <strong>and</strong> vomiting<br />

Category: 5-HT3 antagonist; Serotonin type 3 receptor<br />

antagonist<br />

Half-life: 7.3 hours<br />

Reactions<br />

Skin<br />

Diaphoresis<br />

Edema<br />

Facial edema<br />

Peripheral edema<br />

Pruritus<br />

Purpura<br />

Rash (sic)<br />

Urticaria<br />

Eyes<br />

Ocular pigmentation<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

Chills (>2%)<br />

Hot flashes<br />

(1997): Keung AC+, Biopharm <strong>Drug</strong> Dispos 18(4), 361<br />

Myalgia/Myositis/Myopathy/Myotoxicity<br />

Thrombophlebitis

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