Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

180 DIGOXIN
(2006): Oishi A+, Can J Ophthalmol 41(5), 603
Other
Gynecomastia
(2000): Hugues FC+, Ann Med Interne (Paris) (French) 151, 10
(passim)
DIHYDROERGOTAMINE
Trade names: D.H.E. 45 (Xcel); Dergiflux; Dihydergot; Ergont;
Ergovasan; Ikaran; Migranal (Xcel); Orstanorm; Seglor; Verladyn;
Verteblan
Indications: Prevention of vascular headaches
Category: Ergot alkaloid
Half-life: 1.3–3.9 hours
Clinically important, potentially hazardous interactions
with: almotriptan, amprenavir, clarithromycin, darunavir,
delavirdine, efavirenz, erythromycin, fosamprenavir, indinavir,
naratriptan, nelfinavir, ritonavir, rizatriptan, saquinavir,
sibutramine, sumatriptan, telithromycin, tipranavir,
troleandomycin, zolmitriptan
Reactions
Skin
Edema (>10%)
Necrosis
(1998): Hahne T+, Hautarzt 49(9), 722
(1991): Bongard O+, Vasa 20(2), 153
(1983): Jehn U+, Dtsch Med Wochenschr 108(30), 1148 (with
heparin)
Pruritus
Mucosal
Xerostomia (>10%)
Other
Abdominal pain
(1991): Iaquinto G+, Ital J Gastroenterol 23(4), 219
Gangrene
(1996): Gupta VL+, Acta Anaesthesiol Scand 40(3), 389
Injection-site burning
(1992): Robbins L+, Headache 32(9), 455
Injection-site reactions (sic)
Myalgia/Myositis/Myopathy/Myotoxicity
Thrombosis
(1991): Iaquinto G+, Ital J Gastroenterol 23(4), 219
DIHYDROTACHYSTEROL
Trade names: AT 10; DHT (Roxane); Dihydral; Dygratyl;
Hytakerol (Sanofi-Aventis)
Indications: Hypocalcemia associated with hypoparathyroidism
Category: Vitamin D receptor agonist
Half-life: N/A
Reactions
Skin
Calcification
(1985): Michel B+, Schweiz Med Wochenschr (German) 115, 418
Exanthems
Livedo reticularis
(1985): Michel B+, Schweiz Med Wochenschr (German) 115, 418
Pruritus (1–10%)
Ulcerative necrosis
(1985): Michel B+, Schweiz Med Wochenschr (German) 115, 418
Mucosal
Xerostomia
Other
Myalgia/Myositis/Myopathy/Myotoxicity
DILTIAZEM
Trade names: Alti-Diltiazem; Britiazem; Calcicard; Cardizem
(Biovail); Cartia-XT; Deltazen; Dilacor XR (Watson); Dilrene;
Diltahexal; Diltia-XT; Nu-Diltiaz; Presoken; Teczem (Sanofi-
Aventis); Tiamate; Tiazac (Forest); Tilazem; Tildiem
Indications: Angina, essential hypertension
Category: Antiarrhythmic class IV; Calcium channel blocker
Half-life: 5–8 hours (for extended-release capsules)
Clinically important, potentially hazardous interactions
with: alfuzosin, amiodarone, aprepitant, carbamazepine,
corticosteroids, cyclosporine, epirubicin, erythromycin,
mistletoe, moricizine, ranolazine, simvastatin
Teczem is diltiazem and enalapril
Reactions
Skin
Acne
(1989): Stern R+, Arch Intern Med 149, 829
Acute generalized exanthematous pustulosis (AGEP)
(2003): Saissi EH+, Ann Dermatol Venereol 130(6-7), 612
(2002): Arroyo MP+, J Drugs Dermatol 1(1), 63
(1998): Jan V+, Dermatology 197, 274
(1998): Knowles S+, JAmAcadDermatol38, 201 (passim)
(1997): Blodgett TP+, Cutis 60, 45
(1997): Vincente-Calleja JM+, Br J Dermatol 137, 837
(1996): Wolkenstein P+, Contact Dermatitis 35, 234
(1995): Krasovec M+, Schweiz Rundsch Med Prax (German)
84, 814
(1995): Moreau A+, Int J Dermatol 34, 263 (passim)
(1995): Wakelin SH+, Clin Exp Dermatol 20, 341
(1993): Janier M+, Br J Dermatol 129, 354
(1992): Wittal RA+, Australas J Dermatol 33, 11
(1988): Lambert DG+, Br J Dermatol 118, 308
Adverse effects (sic)
(1993): Barbaud A+, Therapie (French) 48, 499
Angioedema
(1998): Knowles S+, JAmAcadDermatol38, 201 (passim)
(1989): Sadick NS+, JAmAcadDermatol21, 132
Capillaritis (Schamberg’s)
(1999): Eastern JS, Belleville, NJ (from Internet) (observation)
Dermatitis
Diaphoresis
(1988): Lambert DG+, Br J Dermatol 118, 308 (passim)
(1985): Scolnick B+, AnnInternMed102, 558
Edema (1–10%)
(2001): Chugh SK+, J Cardiovasc Pharmacol 38(3), 356
(1998): Knowles S+, JAmAcadDermatol38, 201 (passim)
(1982): Hossack KF, Am J Cardiol 49, 567
(1982): McGraw BF, Drug Intell Clin Pharm 16, 366
Erythema
(1998): Knowles S+, JAmAcadDermatol38, 201 (passim)
(1982): McGraw BF, Drug Intell Clin Pharm 16, 366
Erythema multiforme (1–31%)
(2001): Swale VJ+, Br J Dermatol 144(4), 920