Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Mucosal Oral ulceration Hair Hair – alopecia (1–10%) (1989): Kruis-de Vries MH+, Dermatologica 178, 109 (passim) (1988): Umlas J+, Cutis 42, 63 (1986): Stone MS+, JAmAcadDermatol14, 796 (passim) Other Hypersensitivity DICYCLOMINE Trade names: Antispaz; Bemote; Bentyl (Axcan); Bentylol; Byclomine; Di-Spaz; Dibent; Formulex; Lomine; Merbentyl; Neoquess; Notensyl; OrTyl; Panakiron; Spasmoban; Spasmoject; Swityl Indications: Irritable bowel syndrome Category: Anticholinergic; Muscarinic antagonist Half-life: initial: 1.8 hours; terminal: 9–10 hours Clinically important, potentially hazardous interactions with: anticholinergics, arbutamine Reactions Skin Exanthems (1987): Castleden CM+, J Clin Exp Gerontol 9, 265 Pruritus Rash (sic) (10%) Mucosal Xerostomia (>10%) Other Anaphylactoid reactions/Anaphylaxis Injection-site reactions (sic) (>10%) DIDANOSINE Trade name: Videx (Bristol-Myers Squibb) Indications: Advanced HIV infection Category: Antiretroviral; Nucleoside analog reverse transcriptase inhibitor Half-life: 1.5 hours Clinically important, potentially hazardous interactions with: acetaminophen, ciprofloxacin, corticosteroids, dapsone, itraconazole, ketoconazole, lomefloxacin, sulfones, tenofovir, tetracycline Reactions Skin Acral erythema (1993): Pedailles S+, Ann Dermatol Venereol (French) 120, 837 Diaphoresis Erythema multiforme (2001): Scully C+, Oral Dis 7(4), 205 (passim) (1992): Parneix-Spake A+, Lancet 340, 847 Exanthems Pruritus (9%) Purpura Rash (sic) (9%) Stevens–Johnson syndrome (2003): Rotunda A+, Acta Derm Venereol 83(1), 1 (1992): Parneix-Spake A+, Lancet 340, 847 Urticaria Vasculitis (1994): Herranz P+, Lancet 344, 680 Mucosal Xerostomia (2001): Scully C+, Oral Dis 7(4), 205 (up to 33%) (passim) (1993): Allan JD+, Clin Infect Dis 16 Suppl 1, S46 (1992): Dodd CL+, Lancet 340(8822), 790 (1992): Valentine C+, Lancet 340(8834–8835), 1542 Hair Hair – alopecia (

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