Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Mucosal Oral ulceration Hair Hair – alopecia (1–10%) (1989): Kruis-de Vries MH+, Dermatologica 178, 109 (passim) (1988): Umlas J+, Cutis 42, 63 (1986): Stone MS+, JAmAcadDermatol14, 796 (passim) Other Hypersensitivity DICYCLOMINE Trade names: Antispaz; Bemote; Bentyl (Axcan); Bentylol; Byclomine; Di-Spaz; Dibent; Formulex; Lomine; Merbentyl; Neoquess; Notensyl; OrTyl; Panakiron; Spasmoban; Spasmoject; Swityl Indications: Irritable bowel syndrome Category: Anticholinergic; Muscarinic antagonist Half-life: initial: 1.8 hours; terminal: 9–10 hours Clinically important, potentially hazardous interactions with: anticholinergics, arbutamine Reactions Skin Exanthems (1987): Castleden CM+, J Clin Exp Gerontol 9, 265 Pruritus Rash (sic) (10%) Mucosal Xerostomia (>10%) Other Anaphylactoid reactions/Anaphylaxis Injection-site reactions (sic) (>10%) DIDANOSINE Trade name: Videx (Bristol-Myers Squibb) Indications: Advanced HIV infection Category: Antiretroviral; Nucleoside analog reverse transcriptase inhibitor Half-life: 1.5 hours Clinically important, potentially hazardous interactions with: acetaminophen, ciprofloxacin, corticosteroids, dapsone, itraconazole, ketoconazole, lomefloxacin, sulfones, tenofovir, tetracycline Reactions Skin Acral erythema (1993): Pedailles S+, Ann Dermatol Venereol (French) 120, 837 Diaphoresis Erythema multiforme (2001): Scully C+, Oral Dis 7(4), 205 (passim) (1992): Parneix-Spake A+, Lancet 340, 847 Exanthems Pruritus (9%) Purpura Rash (sic) (9%) Stevens–Johnson syndrome (2003): Rotunda A+, Acta Derm Venereol 83(1), 1 (1992): Parneix-Spake A+, Lancet 340, 847 Urticaria Vasculitis (1994): Herranz P+, Lancet 344, 680 Mucosal Xerostomia (2001): Scully C+, Oral Dis 7(4), 205 (up to 33%) (passim) (1993): Allan JD+, Clin Infect Dis 16 Suppl 1, S46 (1992): Dodd CL+, Lancet 340(8822), 790 (1992): Valentine C+, Lancet 340(8834–8835), 1542 Hair Hair – alopecia (
178 DIETHYLPROPION Erythema (
- Page 202 and 203: (2000): Sharobeem KM+, J Cardiovasc
- Page 204 and 205: (1997): Carrasco JM+, Ann Pharmacot
- Page 206 and 207: CITALOPRAM Synonym: nitalapram Trad
- Page 208 and 209: CLEMASTINE Trade names: Aller-Eze;
- Page 210 and 211: Other Hypersensitivity (2002): Somm
- Page 212 and 213: CLOMIPRAMINE Trade names: Anafranil
- Page 214 and 215: CLOPIDOGREL Trade name: Plavix (Bri
- Page 216 and 217: Eczema (
- Page 218 and 219: (1997): Thaler D, Monona, WI (from
- Page 220 and 221: COCOA Scientific names: Theobroma c
- Page 222 and 223: COLESEVELAM Trade name: Welchol (Sa
- Page 224 and 225: CORDYCEPS Scientific name: Cordycep
- Page 226 and 227: CYCLAMATE Trade name: Sucaryl (Abbo
- Page 228 and 229: Inappropriate secretion of antidiur
- Page 230 and 231: (1996): Cox NH, Clin Exp Dermatol 2
- Page 232 and 233: (2007): Lim AK+, Intern Med J 37(1)
- Page 234 and 235: (1989): Kerker BJ+, Semin Dermatol
- Page 236 and 237: Pruritus (1-10%) Rash (sic) (1-10%)
- Page 238 and 239: (1988): Tham SN+, Singapore Med J 2
- Page 240 and 241: DASATINIB Synonym: BMS354825 Trade
- Page 242 and 243: Other Anaphylactoid reactions/Anaph
- Page 244 and 245: (1980): Miescher PA+, Clin Haematol
- Page 246 and 247: (1985): Job JC+, Arch Fr Pediatr 42
- Page 248 and 249: DEXTROMETHORPHAN Trade names: Balmi
- Page 250 and 251: Erythema nodosum (
- Page 254 and 255: (1987): Masden JJ+, Curr Ther Res 4
- Page 256 and 257: (1998): Knowles S+, JAmAcadDermatol
- Page 258 and 259: Epiphora Other Abdominal pain Fever
- Page 260 and 261: DISOPYRAMIDE Trade names: Dimodan;
- Page 262 and 263: (1995): Cortes JE+, J Clin Oncol 13
- Page 264 and 265: DOMPERIDONE Trade names: Evoxin; Mo
- Page 266 and 267: DOXAPRAM Trade name: Dopram (Baxter
- Page 268 and 269: (1989): Jones AP+, Br J Cancer 59,
- Page 270 and 271: (1992): Bennett MJ, JRArmyMedCorps1
- Page 272 and 273: ECHINACEA Scientific names: Echinac
- Page 274 and 275: Hot flashes (
- Page 276 and 277: Pemphigus vegetans (1994): Bastiaen
- Page 278 and 279: Stevens-Johnson syndrome (
- Page 280 and 281: Ocular pruritus (1-10%) Other Cough
- Page 282 and 283: (2002): Bohm M+, Drug Saf 25(8), 59
- Page 284 and 285: Pustules (1993): Manu Shah R+, Eur
- Page 286 and 287: ESTAZOLAM Trade names: Domnamid; Es
- Page 288 and 289: Allergic reactions (sic) Cellulitis
- Page 290 and 291: Exanthems Photosensitivity Purpura
- Page 292 and 293: Other Anticonvulsant hypersensitivi
- Page 294 and 295: ETORICOXIB Trade names: Algix; Arco
- Page 296 and 297: Purpura (1996): Kallal SM+, West J
- Page 298 and 299: (1980): Couzigou P+, Therapie 35(3)
- Page 300 and 301: FINASTERIDE Trade names: Pro-Cure;
Mucosal<br />
Oral ulceration<br />
Hair<br />
Hair – alopecia (1–10%)<br />
(1989): Kruis-de Vries MH+, Dermatologica 178, 109 (passim)<br />
(1988): Umlas J+, Cutis 42, 63<br />
(1986): Stone MS+, JAmAcadDermatol14, 796 (passim)<br />
Other<br />
Hypersensitivity<br />
DICYCLOMINE<br />
Trade names: Antispaz; Bemote; Bentyl (Axcan); Bentylol;<br />
Byclomine; Di-Spaz; Dibent; Formulex; Lomine; Merbentyl;<br />
Neoquess; Notensyl; OrTyl; Panakiron; Spasmoban; Spasmoject;<br />
Swityl<br />
Indications: Irritable bowel syndrome<br />
Category: Anticholinergic; Muscarinic antagonist<br />
Half-life: initial: 1.8 hours; terminal: 9–10 hours<br />
Clinically important, potentially hazardous interactions<br />
with: anticholinergics, arbutamine<br />
Reactions<br />
Skin<br />
Exanthems<br />
(1987): Castleden CM+, J Clin Exp Gerontol 9, 265<br />
Pruritus<br />
Rash (sic) (10%)<br />
Mucosal<br />
Xerostomia (>10%)<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis<br />
Injection-site reactions (sic) (>10%)<br />
DIDANOSINE<br />
Trade name: Videx (Bristol-Myers Squibb)<br />
Indications: Advanced HIV infection<br />
Category: Antiretroviral; Nucleoside analog reverse<br />
transcriptase inhibitor<br />
Half-life: 1.5 hours<br />
Clinically important, potentially hazardous interactions<br />
with: acetaminophen, ciprofloxacin, corticosteroids, dapsone,<br />
itraconazole, ketoconazole, lomefloxacin, sulfones, tenofovir,<br />
tetracycline<br />
Reactions<br />
Skin<br />
Acral erythema<br />
(1993): Pedailles S+, Ann Dermatol Venereol (French) 120, 837<br />
Diaphoresis<br />
Erythema multiforme<br />
(2001): Scully C+, Oral Dis 7(4), 205 (passim)<br />
(1992): Parneix-Spake A+, Lancet 340, 847<br />
Exanthems<br />
Pruritus (9%)<br />
Purpura<br />
Rash (sic) (9%)<br />
Stevens–Johnson syndrome<br />
(2003): Rotunda A+, Acta Derm Venereol 83(1), 1<br />
(1992): Parneix-Spake A+, Lancet 340, 847<br />
Urticaria<br />
Vasculitis<br />
(1994): Herranz P+, Lancet 344, 680<br />
Mucosal<br />
Xerostomia<br />
(2001): Scully C+, Oral Dis 7(4), 205 (up to 33%) (passim)<br />
(1993): Allan JD+, Clin Infect Dis 16 Suppl 1, S46<br />
(1992): Dodd CL+, Lancet 340(8822), 790<br />
(1992): Valentine C+, Lancet 340(8834–8835), 1542<br />
Hair<br />
Hair – alopecia (
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