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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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176 DICLOXACILLIN<br />

DICLOXACILLIN<br />

Trade names: Brispen; Dichlor-Stapenor; Diclo; Diclocil;<br />

Diclocillin; Diclox; Dycill (GSK); Dynapen; Novapen; Pathocil;<br />

Posipen<br />

Indications: Infections due to penicillinase-producing<br />

staphylococci<br />

Category: Antibiotic, penicillin<br />

Half-life: 0.5–1.0 hours<br />

Clinically important, potentially hazardous interactions<br />

with: anticoagulants, cyclosporine, imipenem/cilastatin,<br />

methotrexate, tetracycline, warfarin<br />

Reactions<br />

Skin<br />

Angioedema<br />

Bullous dermatitis<br />

Dermatitis<br />

Erythema multiforme<br />

(1991): Porteous DM+, Arch Dermatol 127, 740<br />

Erythema nodosum<br />

Erythroderma<br />

(1985): Shelley WB+, Cutis 220, 224<br />

Exanthems (

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