Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

DEXTROMETHORPHAN
Trade names: Balminil; Benylin; Cheracol-D; Delsym; Koffex;
Pertussin; Robitussin (Wyeth); Sucrets; Suppress; Triaminic DM;
Trocal; Vicks Formula 44 (Procter & Gamble)
Indications: Nonproductive cough
Category: Analgesic, narcotic; NMDA receptor antagonist
Half-life: N/A
Clinically important, potentially hazardous interactions
with: linezolid, memantine, phenelzine, rasagiline, sibutramine,
tranylcypromine, valdecoxib
Reactions
Skin
Bullous dermatitis
(1999): Sahn EE, Dermatology Times April, 5 (infant with urticaria
pigmentosa)
(1996): Cook J+, Pediatr Dermatol 13, 410 (infant with urticaria
pigmentosa)
Fixed eruption
(1991): Smoller BR+, JCutanPathol18, 13
(1990): Stubb S+, Arch Dermatol 126, 970
Other
Anaphylactoid reactions/Anaphylaxis
(1998): Knowles SR+, J Allergy Clin Immunol 102, 316
Neurotoxicity
(2006): Cherkes JK+, Neurology 66(12), 1952
DIACETYLMORPHINE
(See HEROIN)
DIATRIZOATE
Trade name: Gastrografin (Schering)
Indications: Imaging (gastrointestinal tract)
Category: Iodine-containing radiocontrast medium
Half-life: N/A
Clinically important, potentially hazardous interactions
with: N/A
Reactions
Skin
Dermatitis
Pruritus
(1992): Choyke PL+, Radiology 183(1), 111
Rash (sic)
(1992): Choyke PL+, Radiology 183(1), 111
Toxic epidermal necrolysis
(1998): Schmidt BJ+, Am J Roentgenol 171(5), 1215
Urticaria
Other
Anaphylactoid reactions/Anaphylaxis (rare)
(2004): Seymour CW+, JTrauma57(5), 1105 (rare)
(1997): Miller SH, Am J Roentgenol 168(4), 959 (rare)
(1992): Ishiyama T+, Masui 41(8), 1314 (rare)
(1982): Boden WE, Chest 81(6), 759 (rare)
Death
(1983): Schneiderman H+, JAMA 250(17), 2340
Rhabdomyolysis
(1991): Carena J+, Medicina (B Aires) 51(4), 348
DIAZEPAM
Trade names: Assival; Dialar; Diapax; Diastat (Xcel); Diazemuls;
Dizac; Ducene; E-Pam; Meval; Novazam; Solis; Valium (Roche);
Vivol
Indications: Anxiety
Category: Benzodiazepine; Skeletal muscle relaxant
Half-life: 20–70 hours
Clinically important, potentially hazardous interactions
with: alcohol, amprenavir, barbiturates, buprenorphine,
chlorpheniramine, clarithromycin, CNS depressants, efavirenz,
esomeprazole, eucalyptus, fluoroquinolones, imatinib, indinavir,
ivermectin, macrolide antibiotics, MAO inhibitors, methadone,
nalbuphine, narcotics, nelfinavir, nilutamide, phenothiazines,
ritonavir, SSRIs
Reactions
DIAZEPAM 173
Skin
Acne
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)
(2000): Guimera FJ+, Int J Dermatol 39(10), 795
Allergic reactions (sic)
(1982): Allin DM, Curr Med Res Opin 8, 33
Angioedema
Bullous dermatitis
Dermatitis (1–10%)
(1995): Fisher AA, Cutis 55, 327 (systemic)
(1995): Kampgen E+, Contact Dermatitis 33, 356
(1994): Garcia-Bravo B+, Contact Dermatitis 30, 40
Diaphoresis (>10%)
Eczema
Exanthems
(1986): Bigby M+, JAMA 256, 3358 (0.04%)
(1981): Adverse Drug Reaction List, Jpn Med Gaz (Japanese)
18:6–7, 16
Exfoliative dermatitis
Fixed eruption (10%)
(1983): O’Brien JE+, Curr Ther Res 34, 825
Urticaria
(1987): Deardon DJ+, Br J Anaesth 59, 391
Vasculitis
(1999): Olcina GM+, Am J Psychiatry 156, 972
Mucosal
Sialorrhea
Tongue furry
Xerostomia (>10%)