Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
DASATINIB Synonym: BMS354825 Trade name: SPRYCEL (Bristol-Myers Squibb) Indications: Leukemia (chronic myeloid), acute lymphoblastic leukemia Category: Tyrosine kinase inhibitor Half-life: 4–6 hours Clinically important, potentially hazardous interactions with: atazanavir, carbamazepine, clarithromycin, dexamethasone, erythromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenobarbital, phenytoin, rifampicin, ritonavir, saquinavir, St John’s wort Reactions Skin Pruritus (11%) Rash (sic) (39%) Mucosal Mucositis (16%) Other Abdominal pain (25%) Chills (11%) Cough (28%) Fever (39%) Myalgia/Myositis/Myopathy/Myotoxicity (12%) Neurotoxicity (13%) Pain (26%) Panniculitis (2006): Assouline S+, NEnglJMed354(24), 2623 DAUNORUBICIN Synonyms: daunomycin; DNR; rubidomycin Trade names: Cerubidine; Daunoxome Indications: Acute leukemias Category: Antibiotic, anthracycline Half-life: 14–20 hours Clinically important, potentially hazardous interactions with: aldesleukin Reactions Skin Angioedema (1983): Bronner AK+, JAmAcadDermatol9, 645 (1981): Weiss RB+, AnnInternMed94, 66 (1–5%) Dermatitis (1986): Eddy JL+, Oncol Nurs Forum 13, 9 Erythema Exanthems Exfoliative dermatitis (2004): Huang JY+, Anticancer Drugs 15(3), 239 Folliculitis (1997): Fournier S+, Arch Dermatol 133, 918 (disseminated) Hand–foot syndrome (2000): Hui YF+, Pharmacotherapy 20(10), 1221 Hypomelanosis Neutrophilic eccrine hidradenitis (1993): Nikkels AF+, Acta Clin Belg 48(6), 397 (1993): Thorisdottir K+, JAmAcadDermatol28, 775 Pigmentation (2002): Kroumpouzos G+, JAmAcadDermatol46(2), S1 (generalized) (1992): Anderson LL+, JAmAcadDermatol26, 255 (1984): Kelly TM+, Arch Dermatol 120, 262 Pruritus Rash (sic) (10%) Hair Hair – alopecia (>10%) (1997): Fournier S+, Arch Dermatol 133, 918 Nails Nails – pigmentation (
166 DECITABINE Peripheral edema (25%) Petechiae (39%) Pruritus (11%) Rash (sic) (19%) (2000): Schwartsmann G+, Invest New Drugs 18(1), 83 (with cisplatin) Urticaria (6%) Mucosal Gingival bleeding (8%) Glossodynia (5%) Lip ulceration (5%) Mucositis (2000): Schwartsmann G+, Invest New Drugs 18(1), 83 (with cisplatin) (1997): Schwartsmann G+, Leukemia Suppl 1, S28 (with daunorubicin) Oral candidiasis (6%) Stomatitis (12%) Tongue ulceration (7%) Hair Hair – alopecia (1997): Schwartsmann G+, Leukemia Suppl 1, S28 (with daunorubicin) Eyes Vision blurred (6%) Other Abdominal pain (14%) Anaphylactoid reactions/Anaphylaxis Cough (40%) Fever (53%) Hypersensitivity Infections (2000): Wijermans P+, J Clin Oncol 18(5), 956 Injection-site edema (5%) Myalgia/Myositis/Myopathy/Myotoxicity (5%) Pain (13%) Upper respiratory infection DEFERASIROX Trade name: Exjade (Novartis) Indications: Chronic iron overload due to blood transfusions Category: Chelator, iron Half-life: 8–16 hours Clinically important, potentially hazardous interactions with: N/A Reactions Skin Purpura Rash (sic) (8%) (2007): Vichinsky E+, Br J Haematol 136(3), 501 (2006): Cappellini MD+, Blood 107(9), 3455 (2006): Vanorden HE+, Ann Pharmacother 40(6), 1110 Urticaria (4%) Eyes Cataract Ocular pressure Visual disturbances Other Abdominal pain (14%) (2007): Vichinsky E+, Br J Haematol 136(3), 501 Cough (14%) Upper respiratory infection (9%) DEFEROXAMINE Trade names: Desferal (Novartis); Desferin Indications: Hemochromatosis, acute iron overload Category: Chelator, iron Half-life: 6.1 hours Clinically important, potentially hazardous interactions with: ascorbic acid, zinc Reactions Skin Acne Angioedema (1984): Romeo MA+, J Inherited Metab Dis 7, 121 Depigmentation (2001): Lopez L+, Dermatol Surg 27(9), 795 Dermatitis (1988): Venencie PY+, Ann Dermatol Venereol (French) 115, 1174 Edema (
- Page 190 and 191: CHLORAMBUCIL Trade names: Chloramin
- Page 192 and 193: (1992): Ramselaar CG+, Br J Urol 70
- Page 194 and 195: (1997): Selvaag E, Ann Trop Pediatr
- Page 196 and 197: (1989): Rosen C, Semin Dermatol 8,
- Page 198 and 199: CHOLESTYRAMINE Trade names: Chol-Le
- Page 200 and 201: CIMETIDINE Trade names: Apo-Cimetid
- Page 202 and 203: (2000): Sharobeem KM+, J Cardiovasc
- Page 204 and 205: (1997): Carrasco JM+, Ann Pharmacot
- Page 206 and 207: CITALOPRAM Synonym: nitalapram Trad
- Page 208 and 209: CLEMASTINE Trade names: Aller-Eze;
- Page 210 and 211: Other Hypersensitivity (2002): Somm
- Page 212 and 213: CLOMIPRAMINE Trade names: Anafranil
- Page 214 and 215: CLOPIDOGREL Trade name: Plavix (Bri
- Page 216 and 217: Eczema (
- Page 218 and 219: (1997): Thaler D, Monona, WI (from
- Page 220 and 221: COCOA Scientific names: Theobroma c
- Page 222 and 223: COLESEVELAM Trade name: Welchol (Sa
- Page 224 and 225: CORDYCEPS Scientific name: Cordycep
- Page 226 and 227: CYCLAMATE Trade name: Sucaryl (Abbo
- Page 228 and 229: Inappropriate secretion of antidiur
- Page 230 and 231: (1996): Cox NH, Clin Exp Dermatol 2
- Page 232 and 233: (2007): Lim AK+, Intern Med J 37(1)
- Page 234 and 235: (1989): Kerker BJ+, Semin Dermatol
- Page 236 and 237: Pruritus (1-10%) Rash (sic) (1-10%)
- Page 238 and 239: (1988): Tham SN+, Singapore Med J 2
- Page 242 and 243: Other Anaphylactoid reactions/Anaph
- Page 244 and 245: (1980): Miescher PA+, Clin Haematol
- Page 246 and 247: (1985): Job JC+, Arch Fr Pediatr 42
- Page 248 and 249: DEXTROMETHORPHAN Trade names: Balmi
- Page 250 and 251: Erythema nodosum (
- Page 252 and 253: Mucosal Oral ulceration Hair Hair -
- Page 254 and 255: (1987): Masden JJ+, Curr Ther Res 4
- Page 256 and 257: (1998): Knowles S+, JAmAcadDermatol
- Page 258 and 259: Epiphora Other Abdominal pain Fever
- Page 260 and 261: DISOPYRAMIDE Trade names: Dimodan;
- Page 262 and 263: (1995): Cortes JE+, J Clin Oncol 13
- Page 264 and 265: DOMPERIDONE Trade names: Evoxin; Mo
- Page 266 and 267: DOXAPRAM Trade name: Dopram (Baxter
- Page 268 and 269: (1989): Jones AP+, Br J Cancer 59,
- Page 270 and 271: (1992): Bennett MJ, JRArmyMedCorps1
- Page 272 and 273: ECHINACEA Scientific names: Echinac
- Page 274 and 275: Hot flashes (
- Page 276 and 277: Pemphigus vegetans (1994): Bastiaen
- Page 278 and 279: Stevens-Johnson syndrome (
- Page 280 and 281: Ocular pruritus (1-10%) Other Cough
- Page 282 and 283: (2002): Bohm M+, Drug Saf 25(8), 59
- Page 284 and 285: Pustules (1993): Manu Shah R+, Eur
- Page 286 and 287: ESTAZOLAM Trade names: Domnamid; Es
- Page 288 and 289: Allergic reactions (sic) Cellulitis
DASATINIB<br />
Synonym: BMS354825<br />
Trade name: SPRYCEL (Bristol-Myers Squibb)<br />
Indications: Leukemia (chronic myeloid), acute lymphoblastic<br />
leukemia<br />
Category: Tyrosine kinase inhibitor<br />
Half-life: 4–6 hours<br />
Clinically important, potentially hazardous interactions<br />
with: atazanavir, carbamazepine, clarithromycin, dexamethasone,<br />
erythromycin, indinavir, itraconazole, ketoconazole, nefazodone,<br />
nelfinavir, phenobarbital, phenytoin, rifampicin, ritonavir,<br />
saquinavir, St John’s wort<br />
Reactions<br />
Skin<br />
Pruritus (11%)<br />
Rash (sic) (39%)<br />
Mucosal<br />
Mucositis (16%)<br />
Other<br />
Abdominal pain (25%)<br />
Chills (11%)<br />
Cough (28%)<br />
Fever (39%)<br />
Myalgia/Myositis/Myopathy/Myotoxicity (12%)<br />
Neurotoxicity (13%)<br />
Pain (26%)<br />
Panniculitis<br />
(2006): Assouline S+, NEnglJMed354(24), 2623<br />
DAUNORUBICIN<br />
Synonyms: daunomycin; DNR; rubidomycin<br />
Trade names: Cerubidine; Daunoxome<br />
Indications: Acute leukemias<br />
Category: Antibiotic, anthracycline<br />
Half-life: 14–20 hours<br />
Clinically important, potentially hazardous interactions<br />
with: aldesleukin<br />
Reactions<br />
Skin<br />
Angioedema<br />
(1983): Bronner AK+, JAmAcadDermatol9, 645<br />
(1981): Weiss RB+, AnnInternMed94, 66 (1–5%)<br />
Dermatitis<br />
(1986): Eddy JL+, Oncol Nurs Forum 13, 9<br />
Erythema<br />
Exanthems<br />
Exfoliative dermatitis<br />
(2004): Huang JY+, Anticancer <strong>Drug</strong>s 15(3), 239<br />
Folliculitis<br />
(1997): Fournier S+, Arch Dermatol 133, 918 (disseminated)<br />
H<strong>and</strong>–foot syndrome<br />
(2000): Hui YF+, Pharmacotherapy 20(10), 1221<br />
Hypomelanosis<br />
Neutrophilic eccrine hidradenitis<br />
(1993): Nikkels AF+, Acta Clin Belg 48(6), 397<br />
(1993): Thorisdottir K+, JAmAcadDermatol28, 775<br />
Pigmentation<br />
(2002): Kroumpouzos G+, JAmAcadDermatol46(2), S1<br />
(generalized)<br />
(1992): Anderson LL+, JAmAcadDermatol26, 255<br />
(1984): Kelly TM+, Arch Dermatol 120, 262<br />
Pruritus<br />
Rash (sic) (10%)<br />
Hair<br />
Hair – alopecia (>10%)<br />
(1997): Fournier S+, Arch Dermatol 133, 918<br />
Nails<br />
Nails – pigmentation (
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