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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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162 DANAZOL<br />

(1980): Hosea SW+, AnnInternMed93, 809 (17%)<br />

Hair – hirsutism (10%)<br />

Urticaria<br />

Hair<br />

Hair – hypertrichosis<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

Chills (1–10%)<br />

Death<br />

(1990): Chan CH, Neurology 40(9), 1427<br />

(1980): Cornette M+, Acta Neurol Belg 80(6), 336<br />

Myalgia/Myositis/Myopathy/Myotoxicity<br />

(1995): Wedel DJ+, Mayo Clin Proc 70(3), 241<br />

Thrombophlebitis<br />

DAPSONE<br />

Trade names: Avlosulfon; Dapson; Dapson-Fatol; Maloprim<br />

(Combination); Protogen; Sulfona<br />

Indications: Leprosy, dermatitis herpetiformis<br />

Category: Antibiotic; Antimycobacterial<br />

Half-life: 10–50 hours<br />

Clinically important, potentially hazardous interactions<br />

with: chloroquine, didanosine, furazolidone, ganciclovir,<br />

hydroxychloroquine, methotrexate, pyrimethamine, rifabutin,<br />

rifampin, sulfonamides<br />

Reactions<br />

Skin<br />

Bullous dermatitis (

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