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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Pruritus (1–10%)<br />

Rash (sic) (1–10%)<br />

Hair<br />

Hair – alopecia<br />

(2001): Apsner R+, Blood 97(9), 2914–5<br />

(2000): Barnes C, Blood 96, 1618<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis (1–10%)<br />

(2001): Ueda A+, Nephron 87(1), 93<br />

Injection-site edema<br />

(2000): Szolar-Platzer C+, JAmAcadDermatol43, 920<br />

Injection-site hematoma (1–10%)<br />

Injection-site pain (1–10%)<br />

Injection-site pruritus<br />

(2000): Szolar-Platzer C+, JAmAcadDermatol43, 920<br />

DAN-SHEN<br />

Scientific name: Salvia miltiorrhiza<br />

Family: Labiatae; Lamiaceae<br />

Trade <strong>and</strong> other common names: Huang Ken; Red Rooted<br />

Sage; Red Sage; Salvia Root; Tzu Tan-Ken<br />

Category: Food supplement; Platelet aggregation inhibitor<br />

Purported indications <strong>and</strong> other uses: Circulation problems,<br />

ischemic stroke, angina pectoris, menstrual problems, chronic<br />

hepatitis, abdominal masses, insomnia, acne, psoriasis, eczema,<br />

bruising, hearing loss<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: digoxin, warfarin<br />

Skin<br />

Pruritus<br />

DANAPAROID<br />

Reactions<br />

Trade name: Orgaran (Organon)<br />

Indications: Prevention of postoperative deep thrombosis<br />

Category: Anticoagulant; Heparinoid<br />

Half-life: ~24 hours<br />

Clinically important, potentially hazardous interactions<br />

with: butabarbital, dalteparin, enoxaparin, heparin<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (10%)<br />

(1982): Madanes AE+, AnnInternMed96, 625 (20%)<br />

(1980): Hosea SW+, AnnInternMed93, 809 (8%)<br />

Angioedema<br />

(1993): Litt JZ, Beachwood, OH (personal case) (observation)<br />

(1988): Guillet G+, Dermatologica 177, 370<br />

Diaphoresis (3%)<br />

Edema (>10%)<br />

Erythema multiforme<br />

(1992): Reynolds NJ+, Clin Exp Dermatol 17, 140<br />

(1988): Gately LE+, AnnInternMed109, 85<br />

Exanthems<br />

(1993): Litt JZ, Beachwood, OH (personal case) (observation)<br />

(1989): Ahn YS+, AnnInternMed111, 723 (6%)<br />

(1982): Madanes AE+, AnnInternMed96, 625<br />

Lupus erythematosus<br />

(1994): Yung RL+, Rheum Dis Clin North Am 20, 61<br />

(1991): Sassolas B+, Br J Dermatol 125, 190<br />

(1988): Guillet G+, Dermatologica 177, 370<br />

(1982): Fretwell MD, Allergy Clin Immunol 69, 306<br />

Lymphomatoid papulosis<br />

(1985): Wise C+, Fertil Steril 44, 702<br />

Petechiae<br />

Photosensitivity (

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