Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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CYCLAMATE Trade name: Sucaryl (Abbott) Indications: Sweetening Category: Sweetening agent Half-life: N/A Reactions Skin Angioedema Bullous dermatitis Exanthems Photosensitivity (1981): Fujita M+, Arch Dermatol 117, 246 (passim) Pruritus Urticaria (1981): Fujita M+, Arch Dermatol 117, 246 Other Hypersensitivity (nonallergic) (1998): Ehlers I+, Allergy 53, 1074 *Note: Cyclamate is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens–Johnson syndrome CYCLESONIDE Synonyms: BY 9010; EL 876 Trade name: Omnaris (Altana) Indications: Allergic rhinitis, asthma Category: Corticosteroid, inhaled Half-life: N/A Clinically important, potentially hazardous interactions with: ketoconazole Other Epistaxis (5%) Reactions CYCLOBENZAPRINE Trade names: Benzamin; Cloben; Cyben; Flexeril (McNeil) (Merck); Flexiban; Novo-Cycloprine; Yurelax Indications: Muscle spasms Category: Central muscle relaxant Half-life: 1–3 days Clinically important, potentially hazardous interactions with: cisapride, droperidol, phendimetrazine Reactions Skin Allergic reactions (sic) Angioedema (

152 CYCLOPHOSPHAMIDE (1992): Hann SK+, JDermatol20, 94 (1982): Bailin PL+, Clin Rheum Dis 8, 493 (passim) Facial burning (1994): Kosirog-Glowacki JL+, Ann Pharmacother 28, 197 Graft-versus-host reaction (2001): Valks R+, Arch Dermatol 137, 61 (3 cases) Hand–foot syndrome (2003): Leighl NB+, Clin Lung Cancer 5(2), 107 (with doxorubicin and vincristine) (1989): Matsuyama JR+, Drug Intell Clin Pharm 23, 776 Herpes zoster (2004): Riley P+, Rheumatology (Oxford) 43(4), 491 (2003): Cummins DL+, JAmAcadDermatol49, 276 Keratoacanthoma Lupus erythematosus (2001): McClain S, New York, NY (from Internet) (observation) Lymphoma (1992): Pandya AG+, Arch Dermatol 128, 1626 (passim) (1983): Goslen JB+, Arch Dermatol 119, 326 Myxedema Neutrophilic eccrine hidradenitis (2003): Lienesch DW+, Lupus 12(9), 707 Palmar–plantar erythema (1990): Pagliuca A+, Postgrad Med J 66, 242 Paraneoplastic pemphigus (2004): Preisz K+, Br J Dermatol 150(5), 1018 Pemphigus (2004): Preisz K+, Br J Dermatol 150(5), 1018 Photo-recall (UV) (1993): Williams BJ+, Clin Exp Dermatol 18, 452 (1984): Andersen KE+, Photodermatol 1, 129 Pigmentation (

CYCLAMATE<br />

Trade name: Sucaryl (Abbott)<br />

Indications: Sweetening<br />

Category: Sweetening agent<br />

Half-life: N/A<br />

Reactions<br />

Skin<br />

Angioedema<br />

Bullous dermatitis<br />

Exanthems<br />

Photosensitivity<br />

(1981): Fujita M+, Arch Dermatol 117, 246 (passim)<br />

Pruritus<br />

Urticaria<br />

(1981): Fujita M+, Arch Dermatol 117, 246<br />

Other<br />

Hypersensitivity (nonallergic)<br />

(1998): Ehlers I+, Allergy 53, 1074<br />

*Note: Cyclamate is a sulfonamide <strong>and</strong> can be absorbed systemically.<br />

Sulfonamides can produce severe, possibly fatal, reactions such as<br />

toxic epidermal necrolysis <strong>and</strong> Stevens–Johnson syndrome<br />

CYCLESONIDE<br />

Synonyms: BY 9010; EL 876<br />

Trade name: Omnaris (Altana)<br />

Indications: Allergic rhinitis, asthma<br />

Category: Corticosteroid, inhaled<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: ketoconazole<br />

Other<br />

Epistaxis (5%)<br />

Reactions<br />

CYCLOBENZAPRINE<br />

Trade names: Benzamin; Cloben; Cyben; Flexeril (McNeil)<br />

(Merck); Flexiban; Novo-Cycloprine; Yurelax<br />

Indications: Muscle spasms<br />

Category: Central muscle relaxant<br />

Half-life: 1–3 days<br />

Clinically important, potentially hazardous interactions<br />

with: cisapride, droperidol, phendimetrazine<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

Angioedema (

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