Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

CORDYCEPS
Scientific name: Cordyceps sinensis
Family: Ascomycetes; Clavicipitaceae
Trade and other common names: Caterpillar Fungus;
CordyMax Cs-4 (Pharmanex); Dong Chong Xia Cao; Dong
Chong Zia Cao; Hsia Ts’Ao Tung Ch’Ung; Jinshuibaom;
Tochukaso; Vegetable Caterpillar
Category: Immunomodulator
Purported indications and other uses: Anemia, arrhythmia,
anti-aging, atherosclerosis, bronchitis, cough, dizziness,
hyperlipidemia, athletic performance, lethargy, liver disorders,
male sexual dysfunction, nocturia, tinnitus
Half-life: N/A
Clinically important, potentially hazardous interactions
with: N/A
None
CORTISONE
Reactions
Trade name: Cortone (Merck)
Indications: Arthralgia, dermatoses, ophthalmia, (many others)
Category: Corticosteroid
Half-life: N/A
Clinically important, potentially hazardous interactions
with: chlorpropamide, diuretics, ethambutol, live vaccines,
pancuronium, rifampicin, rifampin
Reactions
Skin
Adverse effects (sic)
(1990): Gerster JC, Rev Med Suisse Romande 110(10), 847
Atrophy
(1981): Kikuchi I+, JDermatol8(5), 419
Leukoderma
Scleroderma
Eyes
Cataract
(1993): Pirga H, Oftalmologia 37(2), 154
(1991): No Authors, Am J Epidemiol 133(6), 541
(1989): Ndiaye PA+, Dakar Med 34(1-4), 161
Glaucoma
(1993): Pirga H, Oftalmologia 37(2), 154
(1989): Ndiaye PA+, Dakar Med 34(1-4), 161
(1986): Peyresblanques J+, Bull Soc Ophtalmol Fr 86(8-9), 1053
(1983): Calixto N+, Bull Mem Soc Fr Ophtalmol 95, 525
(1981): Espildora J+, JFrOphtalmol4(6-7), 503 (22 cases)
(1980): Stocker S+, JFrOphtalmol3(6-7), 415
Other
Lipomatosis
(1988): Bischoff C, Dtsch Med Wochenschr 113(50), 1964
Myalgia/Myositis/Myopathy/Myotoxicity
Neurotoxicity
Tendinopathy/Tendon rupture
CRANBERRY
Scientific name: Vaccinium oxycoccus
Family: Ericaceae
Trade and other common names: Kranbeere; Ronce
d’Amerique; Tsuru-kokemomo
Category: Diuretic; Proanthocyanadin
Purported indications and other uses: Erythema, hyperplasia,
thrush, cystitis, prevention of urinary tract infections, tumor
inhibition, influenza, common cold, scurvy, pleurisy
Half-life: N/A
Reactions
Other
Toxicity (sic)
(2002): Garcia-Calatayud S+, An Esp Pediatr 56(1), 72
Note: Cranberry juice contains oxalates, a common component of
kidney stones, and should be limited in patients with a history of
nephrolithiasis
CREATINE
Scientific names: N-(aminoiminomethyl)-N methyl glycine; Namidinosarcosine
Family: None
Trade and other common names: Cr; Creatine monohydrate
Category: Food supplement
Purported indications and other uses: Improve exercise
performance, increase muscle mass, heart failure, neuromuscular
disease, cholesterol-lowering, amyotrophic lateral sclerosis (ALS),
rheumatoid arthritis, cardiac surgery (IV)
Half-life: N/A
Reactions
CREATINE 149
Skin
Acne
(1998): Gregg LJ, Tulsa, OK (from Internet) (2 observations)
Facial rash (sic)
(1998): US Food & Drug Administration
Pigmented purpuric eruption
(2006): Chorny JA+, Arch Dermatol 142(12), 1662
Purpura
(2006): Chorny JA+, Arch Dermatol 142(12), 1662 (pigmented)
Eyes
Periorbital edema
(1998): US Food & Drug Administration
Other
Anaphylactoid reactions/Anaphylaxis
(1998): US Food & Drug Administration
Myalgia/Myositis/Myopathy/Myotoxicity
(1998): US Food & Drug Administration
Nephrotoxicity
(2006): Sheth NP+, Clin Nephrol 65(2), 134
(2006): Thorsteinsdottir B+, JRenNutr16(4), 341
Rhabdomyolysis
(2007): Do KD+, Clin J Sport Med 17(1), 78
(2006): Sheth NP+, Clin Nephrol 65(2), 134
(2001): Ray TR+, South Med J 94(6), 608
(2000): Robinson SJ, JAmBoardFamPract13(2), 134
(1998): US Food & Drug Administration