Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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COLESEVELAM Trade name: Welchol (Sankyo) Indications: Hypercholesterolemia Category: Bile acid sequestrant Half-life: N/A Reactions Mucosal Oral ulceration Other Myalgia/Myositis/Myopathy/Myotoxicity (2%) COLESTIPOL Trade names: Cholestabyl; Colestid (Pfizer); Lestid Indications: Primary hypercholesterolemia Category: Anion exchange resin; Lipid regulator Half-life: N/A Skin Dermatitis (

148 COLLAGEN Erythema multiforme (1993): Moscona RR+, Plast Reconstr Surg 92(2), 331 Granuloma annulare (1984): Rapaport MJ, Arch Dermatol 120(7), 837 Herpes simplex Induration (1987): DeLustro F+, Plast Reconstr Surg 79(4), 581 (1985): Cooperman L+, JIntMedRes13(2), 109 Inflammation (1995): Gold MH, Dermatol Clin 13(2), 353 Nodular eruption (2005): Thaler MP+, Dermatol Surg 31(11 Pt 2), 1566 Pigmentation (1999): Davis PK, Br J Plast Surg 52(1), 81 Pruritus Rash (sic) Scar (1995): Lemperle G+, Plast Reconstr Surg 1995 Sep; 96(3), 627 Urticaria Other Death (2003): McCarthy DM+, Arch Pathol Lab Med 127(2), E67 Hypersensitivity (2002): Echols KT+, Int Urogynecol J Pelvic Floor Dysfunct 13(1), 52 (2000): Garcia-Domingo MI+, J Investig Allergol Clin Immunol 10(2), 107 (1993): Cukier J+, AnnInternMed118(12), 920 (1991): Frank DH+, Plast Reconstr Surg 87(6), 1080 (1991): Schnitzler L, Rev Fr Gynecol Obstet 86(6), 469 (1989): Elson ML, JDermatolSurgOncol15(3), 301 (2.5%) (1988): Elson ML, JAmAcadDermatol18(4), 707 (3%) (1987): DeLustro F+, Plast Reconstr Surg 79(4), 581 (1984): Kamer FM+, Arch Otolaryngol 110(2), 93 Infections (1998): Faerber GJ+, Tech Urol 4(3), 124 Myalgia/Myositis/Myopathy/Myotoxicity Panniculitis (2000): Garcia-Domingo MI+, J Investig Allergol Clin Immunol 10(2), 107 (1999): Biasi D+, Clin Rheumatol 18(4), 328 *Note: A reaction to the anesthetic, lidocaine, in liquid collagen injections may occur COMFREY Scientific names: Symphytum asperum; Symphytum officinale; Symphytum peregrinum; Symphytum x uplandicum Family: Boraginaceae Trade and other common names: Ass ear; Blackwort; Boneset; Bruisewort; consolida; consormol; consound; gum plant; knitback; Knitbone; nipbone; Russian comfrey; Slippery Root; Wallwort Category: Carminative Purported indications and other uses: Leaf: Gastric and duodenal ulcer, rheumatic pain, gout, arthritis. Topical: poultice for bruises, sprains, athlete’s foot, crural ulcers, mastitis, varicose ulcers. Root: Gastric and duodenal ulcers, hematemesis, colitis, diarrhea. Topical: ulcers, wounds, fractures, hernia Half-life: N/A Clinically important, potentially hazardous interactions with: eucalyptus Reactions Other Death (2003): Dasgupta A, Am J Clin Pathol 120(1), 127 (1990): Yeong ML+, J Gastroenterol Hepatol 5(2), 211 Toxicity (sic) (2002): Rode D, Trends Pharmacol Sci 23(11), 497 Tumors (1988): Abbott PJ, Med J Aust 149(11–12), 678 Note: The FDA warns that comfrey contains pyrrolizidine alkaloids that can cause cirrhosis and liver failure when taken orally in high doses. It is banned in Germany and Canada. Topical application is safer and more effective; allantoin in comfrey stimulates cell proliferation, accelerating wound healing CONIVAPTAN Trade name: Vaprisol (Astellas) Indications: Hyponatremia, SIADH Category: Vasopressin receptor antagonist Half-life: 5 hours Clinically important, potentially hazardous interactions with: clarithromycin, digoxin, indinavir, itraconazole, ketoconazole, ritonavir Note: Conivaptan is a potent inhibitor of CYP3A4 Reactions Skin Erythema (3%) Peripheral edema (5%) Mucosal Oral candidiasis (2%) Xerostomia (4%) Other Application-site edema (3%) Application-site erythema (5%) Application-site pain (8%) Application-site reactions (52%) Fever (4%) Phlebitis (5%)

COLESEVELAM<br />

Trade name: Welchol (Sankyo)<br />

Indications: Hypercholesterolemia<br />

Category: Bile acid sequestrant<br />

Half-life: N/A<br />

Reactions<br />

Mucosal<br />

Oral ulceration<br />

Other<br />

Myalgia/Myositis/Myopathy/Myotoxicity (2%)<br />

COLESTIPOL<br />

Trade names: Cholestabyl; Colestid (Pfizer); Lestid<br />

Indications: Primary hypercholesterolemia<br />

Category: Anion exchange resin; Lipid regulator<br />

Half-life: N/A<br />

Skin<br />

Dermatitis (

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