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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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146 COENZYME Q-10<br />

COENZYME Q-10<br />

Scientific names: Mitoquinone; Ubidecarenone; Ubiquinone<br />

Family: None<br />

Trade <strong>and</strong> other common names: Co Q10; Co-Q10; CoQ;<br />

CoQ-10; Q10<br />

Category: Food supplement<br />

Purported indications <strong>and</strong> other uses: Congestive heart<br />

failure, angina, diabetes, hypertension, breast cancer, increasing<br />

exercise tolerance, muscular dystrophy, chronic fatigue<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: warfarin<br />

None<br />

Reactions<br />

Note: CoQ-10 was first identified in 1957. It is widely used in Japan<br />

where millions of Japanese patients receive CoQ-10 as part of their<br />

treatment for congestive heart failure<br />

COLCHICINE<br />

Trade names: Cochiquim; ColBenemid; Colchineos; Colgout;<br />

Goutnil; Kolkicin; Konicine<br />

Indications: Gouty arthritis<br />

Category: Alkaloid; Anti-inflammatory<br />

Half-life: 20 minutes<br />

Clinically important, potentially hazardous interactions<br />

with: clarithromycin, erythromycin, trole<strong>and</strong>omycin<br />

*Note: ColBenemid is colchicine <strong>and</strong> probenecid<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

(2001): Vittori F+, Therapie 56(1), 63<br />

Angioedema<br />

Behçet’s disease<br />

(2003): Fujii Y+, Ryumachi Feb 43(1), 44<br />

Bullous dermatitis (

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