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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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138 CLONAZEPAM<br />

Injection-site thrombosis<br />

Pseudolymphoma<br />

(1995): Magro CM+, JAmAcadDermatol32, 419<br />

(1988): Kardaun SH+, Br J Dermatol 118(4), 545<br />

CLONIDINE<br />

Trade names: Barclyd; Catapres (Boehringer Ingelheim);<br />

Catapresan; Combivent (Boehringer Ingelheim); Daipres; Dixarit;<br />

Duraclon; Haemiton; Nu-Clonidine; Sulmidine<br />

Indications: Hypertension<br />

Category: Adrenergic alpha-receptor agonist<br />

Half-life: 6–24 hours<br />

Clinically important, potentially hazardous interactions<br />

with: acebutolol, amitriptyline, amoxapine, atenolol, betaxolol,<br />

carteolol, clomipramine, desipramine, dexmethylphenidate,<br />

doxepin, esmolol, imipramine, insulin detemir, insulin glulisine,<br />

metoprolol, nadolol, nortriptyline, penbutolol, pindolol,<br />

propranolol, protriptyline, timolol, tricyclic antidepressants,<br />

trimipramine, verapamil<br />

Combipres is clonidine <strong>and</strong> chlorthalidone<br />

Reactions<br />

Skin<br />

Angioedema (5%)<br />

(1999): Dias VC+, Am J Ther 6, 19<br />

(1987): Dick JBC+, Lancet 1, 516<br />

(1984): Weber MA+, Arch Intern Med 144, 1211<br />

(1984): Weber MA+, Lancet 1, 9<br />

(1983): Boekhorst JC, Lancet 2, 1031<br />

Psoriasis<br />

(1981): Wilkin J, Arch Dermatol 117, 4<br />

Rash (sic) (1–10%)<br />

(1988): Glassman AH, JAMA 259, 2863<br />

Raynaud’s phenomenon (

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