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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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CLOMIPRAMINE<br />

Trade names: Anafranil (Mallinckrodt); Anafranil Retard; Apo-<br />

Clomipramine; Clofranil; Clopress; Placil<br />

Indications: Obsessive-compulsive disorder<br />

Category: Antidepressant, tricyclic; Muscarinic antagonist<br />

Half-life: 21–31 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amprenavir, arbutamine, clonidine, epinephrine,<br />

formoterol, guanethidine, isocarboxazid, linezolid, MAO<br />

inhibitors, phenelzine, quinolones, sparfloxacin, tranylcypromine<br />

Reactions<br />

Skin<br />

Acne (2%)<br />

Allergic reactions (sic) (10%)<br />

Sialorrhea (1–10%)<br />

Tongue black<br />

(2000): Heymann WR, Cutis 66, 25<br />

Xerostomia (>10%)<br />

(2000): Heymann WR, Cutis 66, 25<br />

Hair<br />

Hair – alopecia<br />

(2000): Mercke Y+, Ann Clin Psychiatry 12, 35<br />

Hair – hirsutism<br />

Other<br />

Death<br />

(2003): Burrows DL+, JForensicSci48(3), 683 (with<br />

oxycodone)<br />

Injection-site phlebitis

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