Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
CITALOPRAM Synonym: nitalapram Trade name: Celexa (Forest) Indications: Depression, obsessive-compulsive disorder, panic disorder Category: Antidepressant; Selective serotonin reuptake inhibitor Half-life: 33 hours Clinically important, potentially hazardous interactions with: isocarboxazid, MAO inhibitors, phenelzine, selegiline, St John’s wort, sumatriptan, tramadol, tranylcypromine, trazodone Reactions Skin Acute febrile neutrophilic dermatosis (Sweet’s syndrome) (2004): Mecca P+, JCutanPathol31(2), 189 (with perphenazine and amoxapine) (photodistributed) Cellulitis Dermatitis Diaphoresis (11%) (2005): Tseng WP+, KaohsiungJMedSci21(7), 326 (2001): Bostic JQ+, J Child Adole Pyschopharmacol 11(2), 159 (33%) (1999): Feighner JP+, J Clin Psychiatry 60(12), 824 Eczema Exanthems (2001): Richard MA+, Ann Dermatol Venereol 128(6), 759 Facial edema Photosensitivity Pigmentation (2001): Inaloz HS+, JDermatol28(12), 742 Pruritus (
132 CLADRIBINE Vasculitis (2002): Tousi B+, Clin Lab Haematol 24(4), 259 (1 case) Other Death (2004): Ogura M+, Int J Hematol 80(3), 267 (2 cases) Gynecomastia (2001): Abhyankar D+, Leuk Lymphoma 42(1), 243 Infections (2003): Byrd JC+, Leukemia 17(2), 323 (43%) Injection-site edema (9%) Injection-site erythema (9%) Injection-site pain (9%) Injection-site phlebitis (2%) Injection-site thrombosis (2%) Myalgia/Myositis/Myopathy/Myotoxicity (7%) CLARITHROMYCIN Trade names: Biaxin (Abbott); Biaxin HP; Clacine; Clarith; Klacid; Klaricid; Macladin; Veclam Indications: Various infections caused by susceptible organisms Category: Antibiotic, macrolide Half-life: 5–7 hours Clinically important, potentially hazardous interactions with: alprazolam, aprepitant, atorvastatin, benzodiazepines, carbamazepine, chlordiazepoxide, cilostazol, clonazepam, clorazepate, colchicine, conivaptan, cyclosporine, dasatinib, diazepam, digoxin, dihydroergotamine, disopyramide, ergot alkaloids, fluoxetine, flurazepam, fluvastatin, HMG-CoA reductase inhibitors, imatinib, lapatinib, lorazepam, lovastatin, methylprednisolone, methysergide, midazolam, oxazepam, paroxetine, pimozide, pravastatin, prednisone, quazepam, repaglinide, rimonabant, sertraline, simvastatin, solifenacin, temazepam, temsirolimus, triazolam, warfarin, zidovudine Reactions Skin Baboon syndrome (2003): Wolf R+, Dermatol Online J 9(3), 2 (with amoxicillin and omeprazole) Exanthems Fixed eruption (2001): Hamamoto Y+, Clin Exp Dermatol 26(1), 48 (1988): Rosina P+, Contact Dermatitis 38, 105 Henoch-Schonlein purpura (2003): Borras-Blasco J+, Int J Clin Pharmacol Ther 41(5), 213 Phototoxicity (2002): Parkash P+, J Assoc Physicians India 50, 1192 Pruritus (1991): Poirier R, J Antimicrob Chemother 27 (Suppl A), 109 Psoriasis (1994): Ellerin P, The Schoch Letter 44, 47 (#185) (observation) Purpura (2006): Zink A+, Dtsch Med Wochenschr 131(40), 2217 (2003): Borras-Blasco J+, Int J Clin Pharmacol Ther 41(5), 213 (2002): Alexopoulou A+, Eur J Haematol 69(3), 191 Pustules Rash (sic) (3%) Stevens–Johnson syndrome (
- Page 156 and 157: Myalgia/Myositis/Myopathy/Myotoxici
- Page 158 and 159: (1989): Ackerman WE+, Can J Anaesth
- Page 160 and 161: CALFACTANT Trade name: Infasurf (Fo
- Page 162 and 163: CAPSICUM Scientific names: Capsicum
- Page 164 and 165: Lupus erythematosus (2002): Ratliff
- Page 166 and 167: Corneal edema Eyelid twitching Kera
- Page 168 and 169: Stevens-Johnson syndrome (1-10%) (2
- Page 170 and 171: Porphyria variegata (2001): Grieco
- Page 172 and 173: (1983): Rollings HE+, Curr Ther Res
- Page 174 and 175: Dermatitis (1986): Hirata M+, Kokyu
- Page 176 and 177: Other Anaphylactoid reactions/Anaph
- Page 178 and 179: Other Anaphylactoid reactions/Anaph
- Page 180 and 181: Other Anaphylactoid reactions/Anaph
- Page 182 and 183: Candidiasis (
- Page 184 and 185: Herpes zoster (
- Page 186 and 187: Hypersensitivity Injection-site pai
- Page 188 and 189: Other Abdominal pain (25%) Anaphyla
- Page 190 and 191: CHLORAMBUCIL Trade names: Chloramin
- Page 192 and 193: (1992): Ramselaar CG+, Br J Urol 70
- Page 194 and 195: (1997): Selvaag E, Ann Trop Pediatr
- Page 196 and 197: (1989): Rosen C, Semin Dermatol 8,
- Page 198 and 199: CHOLESTYRAMINE Trade names: Chol-Le
- Page 200 and 201: CIMETIDINE Trade names: Apo-Cimetid
- Page 202 and 203: (2000): Sharobeem KM+, J Cardiovasc
- Page 204 and 205: (1997): Carrasco JM+, Ann Pharmacot
- Page 208 and 209: CLEMASTINE Trade names: Aller-Eze;
- Page 210 and 211: Other Hypersensitivity (2002): Somm
- Page 212 and 213: CLOMIPRAMINE Trade names: Anafranil
- Page 214 and 215: CLOPIDOGREL Trade name: Plavix (Bri
- Page 216 and 217: Eczema (
- Page 218 and 219: (1997): Thaler D, Monona, WI (from
- Page 220 and 221: COCOA Scientific names: Theobroma c
- Page 222 and 223: COLESEVELAM Trade name: Welchol (Sa
- Page 224 and 225: CORDYCEPS Scientific name: Cordycep
- Page 226 and 227: CYCLAMATE Trade name: Sucaryl (Abbo
- Page 228 and 229: Inappropriate secretion of antidiur
- Page 230 and 231: (1996): Cox NH, Clin Exp Dermatol 2
- Page 232 and 233: (2007): Lim AK+, Intern Med J 37(1)
- Page 234 and 235: (1989): Kerker BJ+, Semin Dermatol
- Page 236 and 237: Pruritus (1-10%) Rash (sic) (1-10%)
- Page 238 and 239: (1988): Tham SN+, Singapore Med J 2
- Page 240 and 241: DASATINIB Synonym: BMS354825 Trade
- Page 242 and 243: Other Anaphylactoid reactions/Anaph
- Page 244 and 245: (1980): Miescher PA+, Clin Haematol
- Page 246 and 247: (1985): Job JC+, Arch Fr Pediatr 42
- Page 248 and 249: DEXTROMETHORPHAN Trade names: Balmi
- Page 250 and 251: Erythema nodosum (
- Page 252 and 253: Mucosal Oral ulceration Hair Hair -
- Page 254 and 255: (1987): Masden JJ+, Curr Ther Res 4
132 CLADRIBINE<br />
Vasculitis<br />
(2002): Tousi B+, Clin Lab Haematol 24(4), 259 (1 case)<br />
Other<br />
Death<br />
(2004): Ogura M+, Int J Hematol 80(3), 267 (2 cases)<br />
Gynecomastia<br />
(2001): Abhyankar D+, Leuk Lymphoma 42(1), 243<br />
Infections<br />
(2003): Byrd JC+, Leukemia 17(2), 323 (43%)<br />
Injection-site edema (9%)<br />
Injection-site erythema (9%)<br />
Injection-site pain (9%)<br />
Injection-site phlebitis (2%)<br />
Injection-site thrombosis (2%)<br />
Myalgia/Myositis/Myopathy/Myotoxicity (7%)<br />
CLARITHROMYCIN<br />
Trade names: Biaxin (Abbott); Biaxin HP; Clacine; Clarith;<br />
Klacid; Klaricid; Macladin; Veclam<br />
Indications: Various infections caused by susceptible organisms<br />
Category: Antibiotic, macrolide<br />
Half-life: 5–7 hours<br />
Clinically important, potentially hazardous interactions<br />
with: alprazolam, aprepitant, atorvastatin, benzodiazepines,<br />
carbamazepine, chlordiazepoxide, cilostazol, clonazepam,<br />
clorazepate, colchicine, conivaptan, cyclosporine, dasatinib,<br />
diazepam, digoxin, dihydroergotamine, disopyramide, ergot<br />
alkaloids, fluoxetine, flurazepam, fluvastatin, HMG-CoA reductase<br />
inhibitors, imatinib, lapatinib, lorazepam, lovastatin,<br />
methylprednisolone, methysergide, midazolam, oxazepam,<br />
paroxetine, pimozide, pravastatin, prednisone, quazepam,<br />
repaglinide, rimonabant, sertraline, simvastatin, solifenacin,<br />
temazepam, temsirolimus, triazolam, warfarin, zidovudine<br />
Reactions<br />
Skin<br />
Baboon syndrome<br />
(2003): Wolf R+, Dermatol Online J 9(3), 2 (with amoxicillin <strong>and</strong><br />
omeprazole)<br />
Exanthems<br />
Fixed eruption<br />
(2001): Hamamoto Y+, Clin Exp Dermatol 26(1), 48<br />
(1988): Rosina P+, Contact Dermatitis 38, 105<br />
Henoch-Schonlein purpura<br />
(2003): Borras-Blasco J+, Int J Clin Pharmacol Ther 41(5), 213<br />
Phototoxicity<br />
(2002): Parkash P+, J Assoc Physicians India 50, 1192<br />
Pruritus<br />
(1991): Poirier R, J Antimicrob Chemother 27 (Suppl A), 109<br />
Psoriasis<br />
(1994): Ellerin P, The Schoch Letter 44, 47 (#185) (observation)<br />
Purpura<br />
(2006): Zink A+, Dtsch Med Wochenschr 131(40), 2217<br />
(2003): Borras-Blasco J+, Int J Clin Pharmacol Ther 41(5), 213<br />
(2002): Alexopoulou A+, Eur J Haematol 69(3), 191<br />
Pustules<br />
Rash (sic) (3%)<br />
Stevens–Johnson syndrome (
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