Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(2000): Sharobeem KM+, J Cardiovasc Pharmacol Ther 5(1), 33 Rhabdomyolysis (1997): Ramachandran S+, BMJ 314(7094), 1593 (with ibuprofen) (1996): Blain H+, Rev Med Interne 17(10), 859 (with norfloxacin) (1990): Delangre T+, Presse Med 19(39), 1811 (1987): Baglin A+, Therapie 42(2), 247 CIPROFLOXACIN Trade names: Ciflox; Ciloxan Ophthalmic (Alcon); Cimogal; Ciplox; Cipro (Alcon); Ciprobay Uro; Cipromycin; Ciproxin; Italnik; Kenzoflex; Uniflox Indications: Various infections caused by susceptible organisms Category: Antibiotic, quinolone Half-life: 4 hours Clinically important, potentially hazardous interactions with: amiodarone, antacids, antineoplastics, arsenic, bepridil, bismuth, bismuth subsalicylate, bretylium, calcium salts, cocoa, didanosine, disopyramide, duloxetine, erythromycin, iron, magnesium salts, methylxanthines, NSAIDs, phenothiazines, procainamide, quinidine, rasagiline, sotalol, sucralfate, theophylline, tizanidine, tricyclic antidepressants, zinc Ciprofloxacin is chemically related to nalidixic acid Reactions Skin Acne (1989): Rahm V+, Scand J Infect Dis 60, 120 (1988): Campoli-Richards DM+, Drugs 35, 373 (1988): Schacht P+, Infection 16, S29 Acute generalized exanthematous pustulosis (2005): Hausermann P+, Dermatology 211(3), 277 Allergic reactions (sic) (2000): Burke P+, BMJ 320, 679 Angioedema (

128 CIPROFLOXACIN Purpura (2006): Urbina F+, Photodermatol Photoimmunol Photomed 22(2), 111 (2002): Mouraux A+, Rev Neurol (Paris) 158(11), 1115 (1999): Goldberg EI+, J Clin Dermatol 2, 25 (1997): Sapadin A+, New York, American Academy of Dermatology Meeting (SF), Poster #110 (1994): Gamboa F+, Ann Pharmacol 29, 84 Rash (sic) (1–10%) (2006): Matsuoka H+, Leuk Lymphoma 47(8), 1618 (2000): Johansson A+, Pediatr Infect Dis J 19, 449 (2000): Talan DA+, JAMA 283, 1583 (4%) (1995): Chaisson RE, Infections in Medicine 12, 48 (1989): Fass RJ+, Am J Med 87, 164S (1989): Modai J, Am J Med 87, 243S (1989): Rahm V+, Scand J Infect Dis 60, 120 (1989): Schacht P+, Am J Med 87, 98S (1988): Sanders WE, Rev Infect Dis 10, 528 (1988): Schacht P+, Infection 16, S29 Stevens–Johnson syndrome (

128 CIPROFLOXACIN<br />

Purpura<br />

(2006): Urbina F+, Photodermatol Photoimmunol Photomed<br />

22(2), 111<br />

(2002): Mouraux A+, Rev Neurol (Paris) 158(11), 1115<br />

(1999): Goldberg EI+, J Clin Dermatol 2, 25<br />

(1997): Sapadin A+, New York, American Academy of<br />

Dermatology Meeting (SF), Poster #110<br />

(1994): Gamboa F+, Ann Pharmacol 29, 84<br />

Rash (sic) (1–10%)<br />

(2006): Matsuoka H+, Leuk Lymphoma 47(8), 1618<br />

(2000): Johansson A+, Pediatr Infect Dis J 19, 449<br />

(2000): Talan DA+, JAMA 283, 1583 (4%)<br />

(1995): Chaisson RE, Infections in Medicine 12, 48<br />

(1989): Fass RJ+, Am J Med 87, 164S<br />

(1989): Modai J, Am J Med 87, 243S<br />

(1989): Rahm V+, Sc<strong>and</strong> J Infect Dis 60, 120<br />

(1989): Schacht P+, Am J Med 87, 98S<br />

(1988): S<strong>and</strong>ers WE, Rev Infect Dis 10, 528<br />

(1988): Schacht P+, Infection 16, S29<br />

Stevens–Johnson syndrome (

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