Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

(2000): Sharobeem KM+, J Cardiovasc Pharmacol Ther 5(1), 33
Rhabdomyolysis
(1997): Ramachandran S+, BMJ 314(7094), 1593 (with
ibuprofen)
(1996): Blain H+, Rev Med Interne 17(10), 859 (with norfloxacin)
(1990): Delangre T+, Presse Med 19(39), 1811
(1987): Baglin A+, Therapie 42(2), 247
CIPROFLOXACIN
Trade names: Ciflox; Ciloxan Ophthalmic (Alcon); Cimogal;
Ciplox; Cipro (Alcon); Ciprobay Uro; Cipromycin; Ciproxin;
Italnik; Kenzoflex; Uniflox
Indications: Various infections caused by susceptible organisms
Category: Antibiotic, quinolone
Half-life: 4 hours
Clinically important, potentially hazardous interactions
with: amiodarone, antacids, antineoplastics, arsenic, bepridil,
bismuth, bismuth subsalicylate, bretylium, calcium salts, cocoa,
didanosine, disopyramide, duloxetine, erythromycin, iron,
magnesium salts, methylxanthines, NSAIDs, phenothiazines,
procainamide, quinidine, rasagiline, sotalol, sucralfate,
theophylline, tizanidine, tricyclic antidepressants, zinc
Ciprofloxacin is chemically related to nalidixic acid
Reactions
Skin
Acne
(1989): Rahm V+, Scand J Infect Dis 60, 120
(1988): Campoli-Richards DM+, Drugs 35, 373
(1988): Schacht P+, Infection 16, S29
Acute generalized exanthematous pustulosis
(2005): Hausermann P+, Dermatology 211(3), 277
Allergic reactions (sic)
(2000): Burke P+, BMJ 320, 679
Angioedema (