Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
CIMETIDINE Trade names: Apo-Cimetidine; Azucimet; Blocan; Cimedine; Cimehexal; Ciuk; Dyspamet; Novocimetine; Nu-Cimet; Peptol; Stomedine; Tagamet (GSK); Ulcedine; Zymerol Indications: Duodenal ulcer Category: Histamine H2 receptor antagonist Half-life: 2 hours Clinically important, potentially hazardous interactions with: alfuzosin, aminophylline, anisindione, anticoagulants, buprenorphine, butorphanol, caffeine, carmustine, clobazam, cocoa, dicumarol, dofetilide, duloxetine, epirubicin, fentanyl, floxuridine, fluorouracil, galantamine, hydromorphone, itraconazole, ketoconazole, lidocaine, midazolam, morphine, narcotic analgesics, oxycodone, pentazocine, phenytoin, posaconazole, prednisone, propranolol, sufentanil, theophylline, tolazoline, warfarin, xanthines, zaleplon, zolmitriptan, zolpidem Reactions Skin Acne Angioedema (
126 CINACALCET CINACALCET Trade name: Sensipar (Amgen) Indications: Secondary hyperparathyroidism, parathyroid carcinoma Category: Calcimimetic Half-life: 30–40 hours Clinically important, potentially hazardous interactions with: ketoconazole Reactions Other Myalgia/Myositis/Myopathy/Myotoxicity (15%) CINNARIZINE Trade names: Arlevert; Cerepar; Cinarizins; Cinazyn; Cinnabene; Cinnacet; Cinnageron; Cinnarisine; Cinnipirine; Clinadil; Derozin; Diclamina; Ederal; Libotacin; Medozine; Pericephal; Pervasum; Sepan; Stugeron (Janssen); Surepil; Sureptil; Touristil; Vertizin (Ram) Indications: Dizziness, tinnitus, nystagmus, nausea and vomiting, motion sickness Category: Histamine H1 receptor antagonist; Muscarinic antagonist; Peripheral vasodilator Half-life: 4 hours Clinically important, potentially hazardous interactions with: alcohol, barbiturates, hypnotics, narcotic analgesics, sedatives, tranquilizers, tricyclic antidepressants Reactions Skin Diaphoresis Lichen planus (1990): Suys E+, Dermatologica 181(1), 71 (1985): Miyagawa S+, Br J Dermatol 112(5), 607 Lichenoid eruption (2002): Ramallal M+, Pharm World Sci 24(6), 215 Lupus erythematosus (1998): Toll A+, Lupus 7(5), 364 (with sunbathing) Mucosal Xerostomia Eyes Blepharospasm (2006): Alonso-Navarro H+, Clin Neuropharmacol 29(4), 187 Vision blurred Other Abdominal pain (1989): Hausler R+, Acta Otorhinolaryngol Belg 43(2), 177 Adverse effects (sic) (1989): Bhatia RS, J Assoc Physicians India 37(11), 733 Myalgia/Myositis/Myopathy/Myotoxicity CINOXACIN Trade names: Cerexin; Cinobac (Lilly); Cinobact; Cinobactin; Gugecin; Nossacin; Noxigram; Uronorm Indications: Various urinary tract infections caused by susceptible organisms Category: Antibiotic, quinolone Half-life: 1.5 hours Reactions Skin Allergic reactions (sic) Angioedema (
- Page 150 and 151: Punctate keratitis (2004): Northing
- Page 152 and 153: BROMFENAC Trade name: Xibrom (ISTA
- Page 154 and 155: Erythema multiforme (
- Page 156 and 157: Myalgia/Myositis/Myopathy/Myotoxici
- Page 158 and 159: (1989): Ackerman WE+, Can J Anaesth
- Page 160 and 161: CALFACTANT Trade name: Infasurf (Fo
- Page 162 and 163: CAPSICUM Scientific names: Capsicum
- Page 164 and 165: Lupus erythematosus (2002): Ratliff
- Page 166 and 167: Corneal edema Eyelid twitching Kera
- Page 168 and 169: Stevens-Johnson syndrome (1-10%) (2
- Page 170 and 171: Porphyria variegata (2001): Grieco
- Page 172 and 173: (1983): Rollings HE+, Curr Ther Res
- Page 174 and 175: Dermatitis (1986): Hirata M+, Kokyu
- Page 176 and 177: Other Anaphylactoid reactions/Anaph
- Page 178 and 179: Other Anaphylactoid reactions/Anaph
- Page 180 and 181: Other Anaphylactoid reactions/Anaph
- Page 182 and 183: Candidiasis (
- Page 184 and 185: Herpes zoster (
- Page 186 and 187: Hypersensitivity Injection-site pai
- Page 188 and 189: Other Abdominal pain (25%) Anaphyla
- Page 190 and 191: CHLORAMBUCIL Trade names: Chloramin
- Page 192 and 193: (1992): Ramselaar CG+, Br J Urol 70
- Page 194 and 195: (1997): Selvaag E, Ann Trop Pediatr
- Page 196 and 197: (1989): Rosen C, Semin Dermatol 8,
- Page 198 and 199: CHOLESTYRAMINE Trade names: Chol-Le
- Page 202 and 203: (2000): Sharobeem KM+, J Cardiovasc
- Page 204 and 205: (1997): Carrasco JM+, Ann Pharmacot
- Page 206 and 207: CITALOPRAM Synonym: nitalapram Trad
- Page 208 and 209: CLEMASTINE Trade names: Aller-Eze;
- Page 210 and 211: Other Hypersensitivity (2002): Somm
- Page 212 and 213: CLOMIPRAMINE Trade names: Anafranil
- Page 214 and 215: CLOPIDOGREL Trade name: Plavix (Bri
- Page 216 and 217: Eczema (
- Page 218 and 219: (1997): Thaler D, Monona, WI (from
- Page 220 and 221: COCOA Scientific names: Theobroma c
- Page 222 and 223: COLESEVELAM Trade name: Welchol (Sa
- Page 224 and 225: CORDYCEPS Scientific name: Cordycep
- Page 226 and 227: CYCLAMATE Trade name: Sucaryl (Abbo
- Page 228 and 229: Inappropriate secretion of antidiur
- Page 230 and 231: (1996): Cox NH, Clin Exp Dermatol 2
- Page 232 and 233: (2007): Lim AK+, Intern Med J 37(1)
- Page 234 and 235: (1989): Kerker BJ+, Semin Dermatol
- Page 236 and 237: Pruritus (1-10%) Rash (sic) (1-10%)
- Page 238 and 239: (1988): Tham SN+, Singapore Med J 2
- Page 240 and 241: DASATINIB Synonym: BMS354825 Trade
- Page 242 and 243: Other Anaphylactoid reactions/Anaph
- Page 244 and 245: (1980): Miescher PA+, Clin Haematol
- Page 246 and 247: (1985): Job JC+, Arch Fr Pediatr 42
- Page 248 and 249: DEXTROMETHORPHAN Trade names: Balmi
126 CINACALCET<br />
CINACALCET<br />
Trade name: Sensipar (Amgen)<br />
Indications: Secondary hyperparathyroidism, parathyroid<br />
carcinoma<br />
Category: Calcimimetic<br />
Half-life: 30–40 hours<br />
Clinically important, potentially hazardous interactions<br />
with: ketoconazole<br />
Reactions<br />
Other<br />
Myalgia/Myositis/Myopathy/Myotoxicity (15%)<br />
CINNARIZINE<br />
Trade names: Arlevert; Cerepar; Cinarizins; Cinazyn;<br />
Cinnabene; Cinnacet; Cinnageron; Cinnarisine; Cinnipirine;<br />
Clinadil; Derozin; Diclamina; Ederal; Libotacin; Medozine;<br />
Pericephal; Pervasum; Sepan; Stugeron (Janssen); Surepil;<br />
Sureptil; Touristil; Vertizin (Ram)<br />
Indications: Dizziness, tinnitus, nystagmus, nausea <strong>and</strong> vomiting,<br />
motion sickness<br />
Category: Histamine H1 receptor antagonist; Muscarinic<br />
antagonist; Peripheral vasodilator<br />
Half-life: 4 hours<br />
Clinically important, potentially hazardous interactions<br />
with: alcohol, barbiturates, hypnotics, narcotic analgesics,<br />
sedatives, tranquilizers, tricyclic antidepressants<br />
Reactions<br />
Skin<br />
Diaphoresis<br />
Lichen planus<br />
(1990): Suys E+, Dermatologica 181(1), 71<br />
(1985): Miyagawa S+, Br J Dermatol 112(5), 607<br />
Lichenoid eruption<br />
(2002): Ramallal M+, Pharm World Sci 24(6), 215<br />
Lupus erythematosus<br />
(1998): Toll A+, Lupus 7(5), 364 (with sunbathing)<br />
Mucosal<br />
Xerostomia<br />
Eyes<br />
Blepharospasm<br />
(2006): Alonso-Navarro H+, Clin Neuropharmacol 29(4), 187<br />
Vision blurred<br />
Other<br />
Abdominal pain<br />
(1989): Hausler R+, Acta Otorhinolaryngol Belg 43(2), 177<br />
Adverse effects (sic)<br />
(1989): Bhatia RS, J Assoc Physicians India 37(11), 733<br />
Myalgia/Myositis/Myopathy/Myotoxicity<br />
CINOXACIN<br />
Trade names: Cerexin; Cinobac (Lilly); Cinobact; Cinobactin;<br />
Gugecin; Nossacin; Noxigram; Uronorm<br />
Indications: Various urinary tract infections caused by<br />
susceptible organisms<br />
Category: Antibiotic, quinolone<br />
Half-life: 1.5 hours<br />
Reactions<br />
Skin<br />
Allergic reactions (sic)<br />
Angioedema (
Change language