Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

CHOLESTYRAMINE
Trade names: Chol-Less; Colestrol; Lismol; PMS-
Cholestyramine; Prevalite; Quantalan; Questran (Par); Questran
Lite
Indications: Pruritus associated with biliary obstruction, primary
hypercholesterolemia
Category: Bile acid sequestrant
Half-life: N/A
Clinically important, potentially hazardous interactions
with: acetaminophen, acitretin, aspirin, chloroquine, digoxin,
doxepin, fat-soluble vitamins A, D, E, K, hydroxychloroquine,
isotretinoin, lovastatin, mycophenolate, raloxifene, sulfasalazine,
sulfonylureas, tetracycline, tricyclic antidepressants, valproic acid
Reactions
Skin
Edema
Exanthems
Hemorrhage
(1986): Shojania AM+, CMAJ 134(6), 609
Pruritus
(2003): Vroonhof K+, Neth J Med 61(1), 19
Rash (sic) (10%)
(2000): Calista D, J Eur Acad Dermatol Venereol 14(6), 484
Pruritus (1–10%)
Rash (sic) (27%)
(2005): Kuypers DR+, Am J Transplant 5(8), 1997
(2005): Shehab N+, Pharmacotherapy 25(7), 977
Toxicity (sic)
(2003): Ljungman P+, Bone Marrow Transplant 31(6), 481
Urticaria (1–10%)
Xerosis
Mucosal
Aphthous stomatitis
Oral candidiasis
Oral ulceration
Stomatitis (1–10%)
Tongue pigmentation
Xerostomia
Hair
Hair – alopecia (22%)
(2000): Calista D, J Eur Acad Dermatol Venereol 14(6), 484
(transient)
(2000): Seijas M+, Rev Clin Esp 200(10), 584