Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

120 CHLOROTRIANISENE
CHLOROTRIANISENE
Trade names: Estregur; Merbentul; Tace
Indications: Inoperable prostate cancer, atrophic vaginitis
Category: Selective estrogen receptor modulator (SERM)
Half-life: N/A
Clinically important, potentially hazardous interactions
with: hydrocortisone
Skin
Acne
Chloasma (1%)
Erythema
Erythema multiforme
Erythema nodosum
Melasma (10%)
Photosensitivity
Rash (sic) (10%)
Porphyria cutanea tarda
Reactions
CHLORPHENIRAMINE
Trade names: AL-R; Aller-Chlor; Chlo-Amine; Chlor-Pro;
Chlor-Trimeton (Schering); Chlor-Tripolon; Chlorate; Ornade;
Phenetron; Telachlor; Teldrin; Triaminic (Novartis)
Indications: Allergic rhinitis, urticaria
Category: Histamine H1 receptor antagonist; Muscarinic
antagonist
Half-life: 20–40 hours
Clinically important, potentially hazardous interactions
with: alcohol, anticholinergics, barbiturates, benzodiazepines,
butabarbital, chloral hydrate, chlordiazepoxide, chlorpromazine,
clonazepam, clorazepate, diazepam, ethchlorvynol, fluphenazine,
flurazepam, hypnotics, lorazepam, MAO inhibitors,
mephobarbital, mesoridazine, midazolam, narcotics, oxazepam,
pentobarbital, phenobarbital, phenothiazines, primidone,
prochlorperazine, promethazine, quazepam, secobarbital,
sedatives, temazepam, thioridazine, tranquilizers, trifluoperazine,
zolpidem
Skin
Angioedema (1–10%)
Dermatitis (1–10%)
Reactions
(2005): Brown VL+, Contact Dermatitis 52(1), 49
(2002): Kuroda K+, Dermatology 205(3), 281
(2001): Hayashi K+, Contact Dermatitis 44(1), 38
(1990): Tosti A+, Contact Dermatitis 22, 55 (eye-drops)
Diaphoresis
Photosensitivity (1–10%)
Pruritus
(1997): Sowunmi A+, Trans R Soc Trop Med Hyg 91(1), 63
Mucosal
Xerostomia (1–10%)
Other
Hypersensitivity
Myalgia/Myositis/Myopathy/Myotoxicity (