Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

CHLORAMBUCIL
Trade names: Chloraminophene; Leukeran (GSK); Linfolysin
Indications: Chronic lymphocytic leukemia, lymphomas,
carcinomas
Category: Alkylating agent
Half-life: 1.5 hours
Clinically important, potentially hazardous interactions
with: aldesleukin, antineoplastics, azathioprine, bone marrow
suppressants, prednisone, vaccines
Reactions
Skin
Angioedema
Dermatitis
(2002): Goon AT+, Contact Dermatitis 47(5), 309 (with
melphalan)
Edema
Erythema multiforme
(1987): Hitchens RN+, Aust N Z J Med 17, 600
Exanthems
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin
Blackwell, Oxford, 289 (passim)
(1987): Hitchens RN+, Aust N Z J Med 17, 600
(1986): Peterman A+, Arch Dermatol 122, 1358
Exfoliative dermatitis
(2006): Kilickap S+, Am J Hematol 81(11), 891
(1987): Hitchens RN+, Aust N Z J Med 17, 600
Facial erythema
(1986): Peterman A+, Arch Dermatol 122, 1358
Herpes simplex
(1984): Sahgal SM+, JRSocMed77, 144
Herpes zoster
(2003): Martinelli G+, Br J Haematol 123(2), 271 (2 cases) (with
rituximab)
(2002): Goldstein DA+, Ophthalmology 109(2), 370
Kaposi’s sarcoma
Lupus erythematosus
(1986): Peterman A+, Arch Dermatol 122, 1358
Necrosis
Perianal irritation
(2003): Martinelli G+, Br J Haematol 123(2), 271 (with
rituximab)
Peripheral edema
(1987): Schmutz JL+, Ann Dermatol Venereol (French) 114, 569
Photosensitivity
(1987): Schmutz JL+, Ann Dermatol Venereol (French) 114, 569
Pruritus
Psoriasis (exacerbation)
Purpura
(1990): Pietrantonio F+, Cancer Lett 54, 109
Rash (sic) (1–10%)
Sezary syndrome
(1981): Ferme F+, Leuk Res 5, 169
Side effects (sic)
Stevens–Johnson syndrome
Toxic epidermal necrolysis
(1997): Aydogdu I+, Anticancer Drugs 8, 468
(1990): Barone C+, Eur J Cancer 26, 1262
(1990): Pietrantonio F+, Cancer Lett 54, 109
Urticaria
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin
Blackwell, Oxford, 289 (passim)
Mucosal
Oral lesions
Oral ulceration (