Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

114 CHASTEBERRY
CHASTEBERRY
Scientific name: Vitex agnus-castus
Family: Verbenaceae
Trade and other common names: Abraham’s Balm; Agno
Casto; Agnocasto; Agnolyt (Madaus); Bish Barmagh Aghaji;
Chaste Lamb-Tree; Chaste tree*; Daribrahim; Gatilier; Hayit;
Hemp Tree; Kaff Maryam; Keuschlamm; Lygos; Monks Pepper;
Panjangusht; Ranukabija; Safe Tree; Sauzgatillo; Seiyo-Ninzin-
Boku; Shajerat Ebrahim; Strotan; Vitex; Ze 440
Category: Hormone modulator
Half-life: N/A
Clinically important, potentially hazardous interactions
with: dopamine-receptor antagonists
Reactions
Skin
Abscess
(2001): Schellenberg R, BMJ 322(7279), 134 (mild)
Acne
(2001): Schellenberg R, BMJ 322(7279), 134 (mild)
Adverse effects (sic)
(2001): Schellenberg R, BMJ 322(7279), 134 (mild)
(2000): Loch EG+, J Womens Health Gend Based Med 9(3), 315
(1.2%)
Formication
Pruritus
Rash (sic)
Urticaria
(2001): Schellenberg R, BMJ 322(7279), 134 (mild)
Note: Chasteberry is not a phytoestrogen; it appears to stimulate
progesterone production
*Note: The Catholic church once placed it in the pockets of
neophyte monks to help them to maintain their vow of chastity
CHICORY
Scientific name: Cichorium intybus
Family: Compositae
Trade and other common names: Barbe de Capucin; Belgian
endive; Hendibeh; Succory; Wild Succory
Category: Diuretic
Purported indications and other uses: coffee substitute,
jaundice, liver enlargement, gout, rheumatism, skin eruptions
connected with gout, inflammation. Topical: leaves used for
swelling and inflammation. Culinary spice, flavoring
Half-life: N/A
Reactions
Skin
Allergic reactions (sic)
(2003): Cadot P+, Int Arch Allergy Immunol 131(1), 19
(1997): Helbling A+, J Allergy Clin Immunol 99(6), 854
(1996): Cadot P+, Clin Exp Allergy 26(8), 940
Dermatitis
(1983): Malten KE, Contact Dermatitis 9(3), 232
CHLORAL HYDRATE
Synonyms: chloral; hydrated chloral
Trade names: Aquachloral; Chloraldurat; Medianox; Noctec;
Novochlorhydrate; Somnox; Welldorm
Indications: Insomnia, sedation
Category: Anesthetic, general; Hypnotic
Half-life: 8–11 hours
Clinically important, potentially hazardous interactions
with: antihistamines, azatadine, brompheniramine, buclizine,
chlorpheniramine, clemastine, dexchlorpheniramine,
diphenhydramine, meclizine, tripelennamine
Reactions
Skin
Acne
Angioedema
Bullous dermatitis
Dermatitis
(1987): de Groot AC+, Contact Dermatitis 16, 229
Eczema
Erythema
Erythema multiforme
(1991): Porteous DM+, Arch Dermatol 127, 740 (in AIDS)
Exanthems
(1990): Lindner K+, Dermatol Monatsschr (German) 176, 483
Fixed eruption
Lichenoid eruption
Perioral dermatitis
(2001): Caksen H+, Pediatr Dermatol 18(5), 454
Pruritus
(1990): Lindner K+, Dermatol Monatsschr (German) 176, 483
Purpura
Rash (sic) (1–10%)
Ulcerations
Urticaria (1–10%)
Mucosal
Oral lesions
(2001): Caksen H+, Pediatr Dermatol 18(5), 454
Oral ulceration
Stomatitis
Other
Death
(2003): Thurau K+, Arch Kriminol 211(3), 90
(2001): Gaulier JM+, JForensicSci46(6), 1507 (2 cases)
Hypersensitivity