Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Other Abdominal pain (25%) Anaphylactoid reactions/Anaphylaxis (2006): Hanna N+, J Clin Oncol 24(33), 5253 (1%) (2006): Lenz HJ, Oncology (Williston Park) 20(5 Suppl 2), 5 Application-site reactions (sic) (~3%) (2006): Hannoud S+, Ann Dermatol Venereol 133(3), 239 (2006): Patel DD+, Oncology (Williston Park) 20(11), 1373 Chills (with irinotecan) Cough (9%) Fever (2007): Saif MW+, Expert Opin Drug Saf 6(2), 175 (2001): Robert F+, J Clin Oncol 19(13), 3234 (33%) Hypersensitivity (2007): Saif MW+, Expert Opin Drug Saf 6(2), 175 (2005): Prescrire Int 14(80), 215 Pain (19%) CEVIMELINE Trade name: Exovac Indications: Sicca syndrome in patients with Sjøgren’s syndrome Category: Muscarinic cholinergic agonist Half-life: 3–4 hours Reactions Skin Allergic reactions (sic) (1–10%) Bullous dermatitis (

114 CHASTEBERRY CHASTEBERRY Scientific name: Vitex agnus-castus Family: Verbenaceae Trade and other common names: Abraham’s Balm; Agno Casto; Agnocasto; Agnolyt (Madaus); Bish Barmagh Aghaji; Chaste Lamb-Tree; Chaste tree*; Daribrahim; Gatilier; Hayit; Hemp Tree; Kaff Maryam; Keuschlamm; Lygos; Monks Pepper; Panjangusht; Ranukabija; Safe Tree; Sauzgatillo; Seiyo-Ninzin- Boku; Shajerat Ebrahim; Strotan; Vitex; Ze 440 Category: Hormone modulator Half-life: N/A Clinically important, potentially hazardous interactions with: dopamine-receptor antagonists Reactions Skin Abscess (2001): Schellenberg R, BMJ 322(7279), 134 (mild) Acne (2001): Schellenberg R, BMJ 322(7279), 134 (mild) Adverse effects (sic) (2001): Schellenberg R, BMJ 322(7279), 134 (mild) (2000): Loch EG+, J Womens Health Gend Based Med 9(3), 315 (1.2%) Formication Pruritus Rash (sic) Urticaria (2001): Schellenberg R, BMJ 322(7279), 134 (mild) Note: Chasteberry is not a phytoestrogen; it appears to stimulate progesterone production *Note: The Catholic church once placed it in the pockets of neophyte monks to help them to maintain their vow of chastity CHICORY Scientific name: Cichorium intybus Family: Compositae Trade and other common names: Barbe de Capucin; Belgian endive; Hendibeh; Succory; Wild Succory Category: Diuretic Purported indications and other uses: coffee substitute, jaundice, liver enlargement, gout, rheumatism, skin eruptions connected with gout, inflammation. Topical: leaves used for swelling and inflammation. Culinary spice, flavoring Half-life: N/A Reactions Skin Allergic reactions (sic) (2003): Cadot P+, Int Arch Allergy Immunol 131(1), 19 (1997): Helbling A+, J Allergy Clin Immunol 99(6), 854 (1996): Cadot P+, Clin Exp Allergy 26(8), 940 Dermatitis (1983): Malten KE, Contact Dermatitis 9(3), 232 CHLORAL HYDRATE Synonyms: chloral; hydrated chloral Trade names: Aquachloral; Chloraldurat; Medianox; Noctec; Novochlorhydrate; Somnox; Welldorm Indications: Insomnia, sedation Category: Anesthetic, general; Hypnotic Half-life: 8–11 hours Clinically important, potentially hazardous interactions with: antihistamines, azatadine, brompheniramine, buclizine, chlorpheniramine, clemastine, dexchlorpheniramine, diphenhydramine, meclizine, tripelennamine Reactions Skin Acne Angioedema Bullous dermatitis Dermatitis (1987): de Groot AC+, Contact Dermatitis 16, 229 Eczema Erythema Erythema multiforme (1991): Porteous DM+, Arch Dermatol 127, 740 (in AIDS) Exanthems (1990): Lindner K+, Dermatol Monatsschr (German) 176, 483 Fixed eruption Lichenoid eruption Perioral dermatitis (2001): Caksen H+, Pediatr Dermatol 18(5), 454 Pruritus (1990): Lindner K+, Dermatol Monatsschr (German) 176, 483 Purpura Rash (sic) (1–10%) Ulcerations Urticaria (1–10%) Mucosal Oral lesions (2001): Caksen H+, Pediatr Dermatol 18(5), 454 Oral ulceration Stomatitis Other Death (2003): Thurau K+, Arch Kriminol 211(3), 90 (2001): Gaulier JM+, JForensicSci46(6), 1507 (2 cases) Hypersensitivity

Other<br />

Abdominal pain (25%)<br />

Anaphylactoid reactions/Anaphylaxis<br />

(2006): Hanna N+, J Clin Oncol 24(33), 5253 (1%)<br />

(2006): Lenz HJ, Oncology (Williston Park) 20(5 Suppl 2), 5<br />

Application-site reactions (sic) (~3%)<br />

(2006): Hannoud S+, Ann Dermatol Venereol 133(3), 239<br />

(2006): Patel DD+, Oncology (Williston Park) 20(11), 1373<br />

Chills (with irinotecan)<br />

Cough (9%)<br />

Fever<br />

(2007): Saif MW+, Expert Opin <strong>Drug</strong> Saf 6(2), 175<br />

(2001): Robert F+, J Clin Oncol 19(13), 3234 (33%)<br />

Hypersensitivity<br />

(2007): Saif MW+, Expert Opin <strong>Drug</strong> Saf 6(2), 175<br />

(2005): Prescrire Int 14(80), 215<br />

Pain (19%)<br />

CEVIMELINE<br />

Trade name: Exovac<br />

Indications: Sicca syndrome in patients with Sjøgren’s syndrome<br />

Category: Muscarinic cholinergic agonist<br />

Half-life: 3–4 hours<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (1–10%)<br />

Bullous dermatitis (

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